Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Theodore K, Dayie"'
Autor:
Lukasz T. Olenginski, Solomon K. Attionu, Erica N. Henninger, Regan M. LeBlanc, Andrew P. Longhini, Theodore K. Dayie
Publikováno v:
Viruses, Vol 15, Iss 9, p 1913 (2023)
Hepatitis B virus (HBV) chronically infects millions of people worldwide, which underscores the importance of discovering and designing novel anti-HBV therapeutics to complement current treatment strategies. An underexploited but attractive therapeut
Externí odkaz:
https://doaj.org/article/f6db628c51fb4b35852ef32432fe095d
Autor:
Lukasz T. Olenginski, Wojciech K. Kasprzak, Solomon K. Attionu, Bruce A. Shapiro, Theodore K. Dayie
Publikováno v:
Molecules, Vol 28, Iss 4, p 1803 (2023)
The global burden imposed by hepatitis B virus (HBV) infection necessitates the discovery and design of novel antiviral drugs to complement existing treatments. One attractive and underexploited therapeutic target is ε, an ~85-nucleotide (nt) cis-ac
Externí odkaz:
https://doaj.org/article/4892b6cd81214f32817555a7f2b2fc72
Publikováno v:
Molecules, Vol 26, Iss 18, p 5581 (2021)
RNA structural research lags behind that of proteins, preventing a robust understanding of RNA functions. NMR spectroscopy is an apt technique for probing the structures and dynamics of RNA molecules in solution at atomic resolution. Still, RNA analy
Externí odkaz:
https://doaj.org/article/14e4d91960de4b8eb84cace903777a30
Publikováno v:
Chemical Reviews. 122:9357-9394
RNA is central to the proper function of cellular processes important for life on earth and implicated in various medical dysfunctions. Yet, RNA structural biology lags significantly behind that of proteins, limiting mechanistic understanding of RNA
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 152:1361-1367
We describe the hybrid enzymatic and chemical synthesis of a 2′-O-cyanoethoxymethyl (CEM) [1′,6-13C2, 5-2H]-uridine phosphoramidite (amidite). This is the first report of an atom-specific nucleobase and ribose labeled CEM amidite. Importantly, th
Autor:
John S. Schneekloth, Bruce A. Shapiro, Regan M. LeBlanc, Claudia Del Vecchio, Maryia Svirydava, Theodore K. Dayie, Julie Nyman, Lukasz T. Olenginski, Wojciech Kasprzak, Fardokht A. Abulwerdi, Brigit Shields, Andrew P. Longhini, Stefano Ginocchio, Stuart F. J. Le Grice, Joseph Ivanic
Publikováno v:
J Biomol Struct Dyn
Initiation of protein-primed (−) strand DNA synthesis in hepatitis B virus (HBV) requires interaction of the viral polymerase with a cis-acting regulatory signal, designated epsilon ([Formula: see text]), located at the 5′-end of its pre-genomic
Publikováno v:
Current protocolsLiterature Cited. 2(7)
A combined enzymatic and chemical synthesis of a 2'-O-cyanoethoxymethyl (CEM) protected [1',6
Publikováno v:
Journal of Biomolecular Nmr
Selective stable isotope labeling has transformed structural and dynamics analysis of RNA by NMR spectroscopy. These methods can remove 13C-13C dipolar couplings that complicate 13C relaxation analyses. While these phenomena are well documented for s
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 152:441-447
Solution NMR of the magnetically active fluorine-19 (19F) isotope offers tremendous advantages in the study of RNA structure and conformational changes. However, exploiting these advantages requires the synthesis of fluorinated RNA-building blocks, a
Publikováno v:
Molecules, Vol 24, Iss 19, p 3476 (2019)
RNA structure and dynamic studies by NMR spectroscopy suffer from chemical shift overlap and line broadening, both of which become worse as RNA size increases. Incorporation of stable isotope labels into RNA has provided several solutions to these li
Externí odkaz:
https://doaj.org/article/b5eebae9be70447e900386e47315a1b4