Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Theodore J. Tsomides"'
Publikováno v:
Immunity. 4:565-571
Using a chemically homogeneous radiolabeled peptide of high specific activity (125I-QLSPYPFDL, 3.5 × 1018 cpm per mole) we show that at a peptide concentration (5 pM) causing half-maximal lysis of target cells by a cytolytic T lymphocyte (CTL) clone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba6d97513a4a533ffc42fdf5829887d
https://doi.org/10.1016/s1074-7613(00)80483-5
https://doi.org/10.1016/s1074-7613(00)80483-5
Autor:
Anders Brunmark, Theodore J. Tsomides, Herman N. Eisen, Shigeki Kageyama, Yuri Sykulev, Mike Jackson, Per A. Peterson
Publikováno v:
Proceedings of the National Academy of Sciences. 91:11487-11491
We report here that the intrinsic affinities of the antigen-specific T-cell receptors (TCR) of two unrelated CD8+ T-cell clones for their respective peptide-major histocompatibility complex (MHC) ligands are higher than the values generally thought t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fb1d9c9a6a8ca300622983f4628821
https://doi.org/10.1073/pnas.91.24.11487
https://doi.org/10.1073/pnas.91.24.11487
Autor:
Margaret L. Fahnestock, Linda O. Narhi, Pamela J. Bjorkman, Jennifer L. Johnson, Theodore J. Tsomides, John P. Mayer, R. M. Renny Feldman
Publikováno v:
Biochemistry. 33:8149-8158
Class I major histocompatibility complex (MHC) proteins present peptide antigens to T cells during the immune response against viruses. Peptides are loaded into newly synthesized class I heterodimers in the endoplasmic reticulum such that most or all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb61870ad17c1b4e52a7c8982906b12
https://doi.org/10.1021/bi00192a020
https://doi.org/10.1021/bi00192a020
Autor:
Anna Aldovini, Herman N. Eisen, R P Johnson, Richard A. Young, Theodore J. Tsomides, Bruce D. Walker
Publikováno v:
The Journal of Experimental Medicine
We have established long-term cultures of several cell lines stably and uniformly expressing human immunodeficiency virus type 1 (HIV-1) in order to (a) identify naturally processed HIV-1 peptides recognized by cytotoxic T lymphocytes (CTL) from HIV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4feef6e26a5fff554bfd431d751c41
http://europepmc.org/articles/PMC2191672
http://europepmc.org/articles/PMC2191672
Autor:
Herman N. Eisen, Shigeki Kageyama, Theodore J. Tsomides, Yuri Sykulev, Ioannis A. Papayannopoulos, Naomi Fukusen
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 166(5)
CTL clone 2C recognizes the allogeneic class I MHC molecule Ld in association with peptides derived from α-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase (OGDH)), a ubiquitous intracellular protein. One of these peptides, QLSPFPFDL (QL9), e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701e6812fa7220e573b2f7e29f964a5c
https://pubmed.ncbi.nlm.nih.gov/11207252
https://pubmed.ncbi.nlm.nih.gov/11207252
Publikováno v:
International immunology. 9(2)
A line of tumor-infiltrating lymphocytes (660TIL) specifically lysed the autologous HLA-A2+ melanoma (660MEL) and also most A2+ melanoma cell lines. We immunoprecipitated A2 from a large number (>10(12)) of 660MEL cells, extracted naturally processed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd88970928f6ba13a3323952acaf89b0
https://pubmed.ncbi.nlm.nih.gov/9040014
https://pubmed.ncbi.nlm.nih.gov/9040014
Publikováno v:
Immunity. 5(2)
The number of T cell receptors on CTL clone 2C that are required for recognition of various peptide–MHC or superantigen–MHC ligands were measured as a function of both the ligand density on target cells and the binding affinity of the TCR. Quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b624df177884e853565b26c720d073ec
https://pubmed.ncbi.nlm.nih.gov/8769477
https://pubmed.ncbi.nlm.nih.gov/8769477
Autor:
Theodore J. Tsomides
Publikováno v:
MHC Molecules: Expression, Assembly and Function ISBN: 9781468464641
Studies in the early 1970s revealed a requirement that T lympho-cytes responding to antigens on other cells (B lymphocytes or macrophages) must share MHC specificities with the antigen-bearing cells they recognize in order to become functional helper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::611fb3dbac8017943ba418d8e67c9ae5
https://doi.org/10.1007/978-1-4684-6462-7_12
https://doi.org/10.1007/978-1-4684-6462-7_12
Publikováno v:
Antigen Binding Molecules: Antibodies and T-cell Receptors ISBN: 9780120342495
The chapter gives an overview of an antigen-specific T-cell receptors and their reactions with complexes formed with major histocompatibility complex proteins. The receptors on the two major classes of lymphocytes, B and T cells, are similar structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a9c566aac0cdc24602e6c9fc474857
https://doi.org/10.1016/s0065-3233(08)60487-8
https://doi.org/10.1016/s0065-3233(08)60487-8