Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Theodore J. Torphy"'
1
Considerations for the Conduct of Clinical Trials with Antiinflammatory Agents in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report
Autor: Theodore J, Torphy, Janet, Allen, André M, Cantin, Michael W, Konstan, Frank J, Accurso, Elizabeth, Joseloff, Felix A, Ratjen, James F, Chmiel, Katherine L, Tuggle
Publikováno v: Annals of the American Thoracic Society. 12(9)
Inflammation leads to lung destruction and loss of pulmonary function in patients with cystic fibrosis (CF). Drugs that modulate the cystic fibrosis transmembrane conductance regulator (CFTR) have recently been approved. Although the impact of CFTR m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cece52a1a0bcee9b855dbfd200d63363
https://pubmed.ncbi.nlm.nih.gov/26146892
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2
What's in the Pipeline? Prospects for Monoclonal Antibodies (mAbs) as Therapies for Lung Diseases
Autor: Don E. Griswold, Anuk Das, Theodore J Torphy, Li Li
Publikováno v: Pulmonary Pharmacology & Therapeutics. 15:409-416
The striking clinical results from recent studies with Remicade (infliximab, a monoclonal anti-TNFalpha antibody) in rheumatoid arthritis, Crohn's disease and psoriasis demonstrate the disease-altering potential of monoclonal antibodies (mAbs) in chr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb30049533e28dcc1e63de3e8709007f
https://doi.org/10.1006/pupt.2002.0371
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3
Coming of Age:Anti-Cytokine Therapies
Autor: Theodore J. Torphy, Song Xiao-Yu R, Don E. Griswold, David Shealy
Publikováno v: Molecular Interventions. 2:36-46
Although cytokines are critical in maintaining normal physiology, excessive production of these proteins can lead to pathological consequences. Inhibitors of cytokine production or action are therefore widely investigated as potential therapeutic age
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158726dd565c1a8c964cabe7ef6e1c27
https://doi.org/10.1124/mi.2.1.36
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4
Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B
Autor: Miriam Burman, M Grous, Mary S. Barnette, Carol D. Manning, David M Essayan, Siegfried B. Christensen, L. B. Cieslinski, Theodore J. Torphy
Publikováno v: British Journal of Pharmacology. 128:1393-1398
1. Of the four major phosphodiesterase 4 (PDE4) subtypes, PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells, including monocytes and T lymphocytes. We explored the functional role of these subtypes using ten subtype-selective PD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51a6d705c94ad234a80956c8fada41a2
https://doi.org/10.1038/sj.bjp.0702911
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6
Inactivation of Recombinant Monocyte cAMP-Specific Phosphodiesterase by cAMP Analog, 8-[(4-Bromo-2,3-Dioxobutyl)thio]Adenosine 3′,5′-Cyclic Monophosphate
Autor: Gilbert Scott, Robert W. Colman, George A. Omburo, Theodore J. Torphy, Susanne Jacobitz, Roberta F. Colman
Publikováno v: Blood. 89:1019-1026
Two cAMP analogs, 8- and 2- [(4-bromo-2,3-dioxobutyl) thio]adenosine 3′,5′-cyclic monophosphate (8- and 2-BDB-TcAMP) have been used in probing the catalytic site of recombinant monocyte cAMP-specific phosphodiesterase (PDE4a). 2-BDB-TcAMP is a re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef3a89502909fbfc56ec361f7d96b62f
https://doi.org/10.1182/blood.v89.3.1019
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7
Cysteinyl leukotrienes in asthma: old mediators up to new tricks
Autor: Douglas W. P. Hay, Bradley J. Undem, Theodore J. Torphy
Publikováno v: Trends in Pharmacological Sciences. 16:304-309
The cysteinyl leukotrienes have long been suspected to play a role in the pathogenesis of asthma. This speculation was based largely on their release in human lung following antigen challenge as well as their potent bronchoconstrictor activity. Howev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86241f5c5fc769ed9ffcff85629a1272
https://doi.org/10.1016/s0165-6147(00)89059-8
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8
Characterization of two human cAMP-specific phosphodiesterase subtypes expressed in baculovirus-infected insect cells
Autor: Charles R. Hanning, Megan M. McLaughlin, George P. Livi, Bernard Y. Amegadzie, L. B. Cieslinski, Miriam Burman, Theodore J. Torphy
Publikováno v: Cell Biology International. 19:477-484
Recombinant baculoviruses were constructed to express cDNAs encoding two distinct subtypes of human cAMP-specific phosphodiesterase (hPDE4A and hPDE4B). Infection of Spodoptera frugiperda insect cells with the appropriate recombinant baculoviruses re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53ff31d3c29c1444a98f960967b8b18
https://doi.org/10.1006/cbir.1995.1091
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10
Crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-[(3-cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
Autor: Paul W. Baures, L. B. Cieslinski, Karl F. Erhard, Siegfried B. Christensen, Drake S. Eggleston, Theodore J. Torphy
Publikováno v: Journal of Medicinal Chemistry. 36:3274-3277
Chiral HPLC resolution of the phosphodiesterase IV (PDE IV) inhibitor rolipram (1) provided (-)-1, and this enantiomer was converted into its 1-(4-bromobenzyl) derivative, (+)-2. X-ray structural analysis of (+)-2 established the absolute configurati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b665fd5d4e98c7b97b77f997512ae52
https://doi.org/10.1021/jm00074a007
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