Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Theodore J. Koh"'
Autor:
Theodore J. Koh, Jon Florholmen, D. Mark Pritchard, Shigeo Takaishi, Wandong Ai, Guanglin Cui, Kelly S. Betz, Timothy C. Wang, JeanMarie Houghton
Publikováno v:
Laboratory Investigation. 86:1037-1051
Hypergastrinemia in INS-GAS mice leads to accelerated carcinogenesis of the stomach, but the mechanisms have not been well defined. We investigated the possible role of gastrin-induced gastric cell apoptosis in the development of gastric cancer. We e
Autor:
Raktima Raychowdhury, Theodore J. Koh, Timothy C. Wang, Meixia Bi, Wandong Ai, Natalie F. Sinclair, John McLaughlin
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 286:G992-G999
Gastrin is a known growth/differentiation factor for the gastric mucosa. Its effects are likely mediated by the induction of heparin-binding epidermal-like growth factor (HB-EGF), a member of the EGF family of growth factors that is expressed by gast
Autor:
Andrea Varro, Theodore J. Koh, Pat Fielding, John K. Field, Guanglin Cui, JeanMarie Houghton, Graham J. Dockray, Timothy C. Wang, Triantafillos Liloglou
Publikováno v:
Cancer Research. 64:196-201
The less processed forms of gastrin have recently been shown to act as trophic factors for both normal and malignant colonic cells. Although incompletely processed forms of gastrin such as glycine-extended gastrin and progastrin are also expressed in
Autor:
Theodore J. Koh
Publikováno v:
Pharmacology & Toxicology. 91:368-374
Gastrin is a peptide hormone that regulates both acid secretion and growth of the gastric oxyntic mucosa. Recent studies suggest that gastrin, in both its amidated, and less processed forms (glycine-extended gastrin and progastrin) may also exert bio
Autor:
Graham J. Dockray, Chun-Mei Zhao, Alfred N. Van Hoek, Andrea Varro, Theodore J. Koh, Duan Chen, Natalie Faye Sinclair, Timothy C. Wang
Publikováno v:
Gastroenterology. 119:756-765
Background & Aims: Studies in gastrin-deficient mice have demonstrated critical roles for gastrin peptides in the regulation of gastric acid secretion, but the relative contributions of amidated (G-17) and glycine-extended (G17-Gly) gastrin remain un
Autor:
Theodore J. Koh, Duan Chen
Publikováno v:
Regulatory Peptides. 93:37-44
The peptide hormone gastrin, released from antral G cells, is known to stimulate the synthesis and release of histamine from ECL cells in the oxyntic mucosa via CCK-2 receptors. The mobilized histamine induces acid secretion by binding to the H(2) re
Autor:
Graham J. Dockray, Andrea Varro, John V. Fleming, Timothy C. Wang, Clemens J. Bulitta, Theodore J. Koh
Publikováno v:
Journal of Clinical Investigation. 106:533-539
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene occur in most colorectal cancers and lead to activation of beta-catenin. Whereas several downstream targets of beta-catenin have been identified (c-myc, cyclin D1, PPARdelta), th
Autor:
Graham J. Dockray, James G. Fox, James R. Goldenring, Andrea Varro, Duan Chen, Timothy C. Wang, Charles A. Dangler, Theodore J. Koh, Sus Ito, Raktima Raychowdhury, Robert J. Coffey
Publikováno v:
Gastroenterology. 118:36-47
Background & Aims: Hypergastrinemia occurs frequently in association with acid suppression and Helicobacter infection, but its role in the progression to gastric atrophy and gastric cancer has not been well defined. Methods: The effects of hypergastr
Autor:
Theodore J. Koh, Susumu Ito, Charles A. Dangler, James R. Goldenring, Woo Kyu Jeon, Annegret Mueller, Timothy C. Wang, James G. Fox
Publikováno v:
Gastroenterology. 114:675-689
Background & Aims: Infection with Helicobacter pylori uniformly leads to a chronic superficial gastritis that may progress to atrophic gastritis, a premalignant process. A mouse model of Helicobacter felis infection was used to study possible genetic
Autor:
Charles A. Dangler, Graham J. Dockray, Rachel J. Cahill, Theodore J. Koh, James G. Fox, Timothy C. Wang, Andrea Varro
Publikováno v:
Journal of Clinical Investigation. 98:1918-1929
Incompletely processed gastrins have been postulated to play a role in growth of the gastrointestinal tract, but few studies have examined the effects of progastrin on mucosal proliferation in vivo. Human gastrin gene expression and progastrin proces