Výsledky vyhledávání - "Theodore G. Wright"

Smad inhibition by the Ste20 kinase Misshapen

Autor: Xiaohao Yao, Y. Tony Ip, Ken-ichi Kariya, Junhao Mao, Lan Xu, Satoshi Kaneko, Xiaochu Chen, Theodore G. Wright, Peiyuan Lu, Mihir Rajurkar

Publikováno v: Proceedings of the National Academy of Sciences. 108:11127-11132

The level of TGF-β/bone morphogenetic protein (BMP) signaling through Smad is tightly regulated to ensure proper embryonic patterning and homeostasis. Here we show that Smad activation by TGF-β/BMP is blocked by a highly conserved phosphorylation e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139895ccdeec5ba9c3f7c5f2d5a11d4e
https://doi.org/10.1073/pnas.1104128108

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Improved Recovery and Identification of Membrane Proteins from Rat Hepatic Cells using a Centrifugal Proteomic Reactor*

Autor: Meenakshi Sundaram, Yuwei Wang, Zhibin Ning, Zemin Yao, Daniel Figeys, Shumei Zhong, Fangjun Wang, Theodore G. Wright, Weimin Hou, Hu Zhou

Despite their importance in many biological processes, membrane proteins are underrepresented in proteomic analysis because of their poor solubility (hydrophobicity) and often low abundance. We describe a novel approach for the identification of plas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74828f3d69f1dc93a96c49abce1c7c8
https://europepmc.org/articles/PMC3205877/

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Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells

Autor: Nabil G. Seidah, Janice Mayne, Fred Elisma, Nicholas J. Denis, Maroun Bou Khalil, Annik Prat, Michel Chrétien, Alia Busuttil, Heather Palmer-Smith, Daniel Figeys, Theodore G. Wright

Publikováno v: Journal of proteome research. 10(4)

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in cholesterol homeostasis, mediating degradation of the liver low-density lipoprotein receptor (LDLR). In fact, gain- and loss-of-function PCSK9 variations in human popula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0014eb91b7b00eb9c014a6cfda2b7b
https://pubmed.ncbi.nlm.nih.gov/21332221

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Analysis of the subcellular phosphoproteome using a novel phosphoproteomic reactor

Autor: Houjiang Zhou, Nicholas J. Denis, Fred Elisma, Hu Zhou, Ruijun Tian, Hanfa Zou, Theodore G. Wright, Weimin Hou, Daniel Figeys

Publikováno v: Journal of proteome research. 9(3)

Protein phosphorylation is an important post-translational modification involved in the regulation of many cellular processes. Mass spectrometry has been successfully used to identify protein phosphorylation in specific pathways and for global phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc87b9fce7bbd79ae6f9121422a5f31
https://pubmed.ncbi.nlm.nih.gov/20067319

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Increased production and secretion of HGF alpha-chain and an antagonistic HGF fragment in a human breast cancer progression model

Autor: Jonathan H. Foley, Vinay K. Singh, John J. Li, Bruce E. Elliott, Theodore G. Wright, Zongchao Jia, Frederick W. Miller

Publikováno v: International journal of cancer. 125(5)

Invasive human breast carcinomas frequently coexpress increased hepatocyte growth factor (HGF) and its receptor Met, suggesting that establishment of an autocrine HGF loop is important in malignant disease. This study examines the expression patterns

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7595652ec898844ab9512661035935e
https://pubmed.ncbi.nlm.nih.gov/19415747

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Inhibition by copper(II) binding of hepatocyte growth factor (HGF) interaction with its receptor Met and blockade of HGF/Met function

Autor: Julie Tsai, Zongchao Jia, Bruce E. Elliott, Theodore G. Wright

Publikováno v: The Journal of biological chemistry. 279(31)

Overexpression of hepatocyte growth factor (HGF) and its receptor Met often occurs in carcinoma cells, leading to establishment of an HGF/Met autocrine loop. Therefore, disruption of the HGF/Met autocrine loop may lead to down-regulation of tumorigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec02dc5e6d59481e2262acde2ae19765
https://pubmed.ncbi.nlm.nih.gov/15161915

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Quantitative evaluation of the contribution of weak lysine-binding sites present within apolipoprotein(a) kringle IV types 6-8 to lipoprotein(a) assembly

Autor: P. Michael Cook, Marlys L. Koschinsky, Lev Becker, Theodore G. Wright

Publikováno v: The Journal of biological chemistry. 279(4)

During lipoprotein(a) (Lp(a)) assembly, non-covalent interactions between apolipoprotein(a) (apo(a)) and low density lipoprotein precede specific disulfide bond formation. Studies have shown that the non-covalent step involves an interaction between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c80624f27988ef3ab5829c14c88e5cf
https://pubmed.ncbi.nlm.nih.gov/14581473

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