Výsledky vyhledávání - "Theodore C. SPAULDING"

New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics

Autor: J. R. Bagley, Theodore C. Spaulding, B. M. Doorley, S A Thomas, Michael H. Ossipov, Frieda G. Rudo, H. K. Spencer, Mark J. Benvenga, T. P. Jerussi

Publikováno v: Journal of Medicinal Chemistry. 34:827-841

A series of new 1-(heterocyclyalkyl)-4-(propionanilido)-4-piperidinyl methyl esters and methylene methyl ethers have been synthesized and pharmacologically evaluated. In the mouse hot-plate test, the majority of compounds exhibited an analgesia (ED50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b2488784bafa855e397dd63e2b3563
https://doi.org/10.1021/jm00106a051

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Evaluation of the morphine reversal actions and antinociceptive activity of a new class of opiate antagonists structurally related to fentanyl

Autor: Spencer H Kenneth, Jerome R. Bagley, Richard L Wynn, Theodore C. Spaulding

Publikováno v: Drug Development Research. 22:189-195

Structural changes to the fentanyl molecule based on heterocyclic modifications at the sector distal to the piperidine nitrogen results in morphine reversal activity. A series of such compounds known as 4-(heteroanilido) piperidines were tested for r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a60f6ed1f7632be45122c8018b76dcf0
https://doi.org/10.1002/ddr.430220209

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Synthesis and pharmacological evaluation of a series of new 1,4-disubstituted 3-methyl-piperidine analgesics

Autor: Denny Wright, Nhora Lucia Lalinde, John Moliterni, Theodore C. Spaulding, Spencer H Kenneth, Frieda G. Rudo, Michael H. Ossipov

Publikováno v: Journal of Medicinal Chemistry. 33:2876-2882

The synthesis and intravenous analgesic activity of a series of 3-methyl-4-(N-phenyl amido)piperidines, entries 34-79, is described. The methoxyacetamide pharmacophore produced a series of compounds with optimal analgesic potency and short duration o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0e323685bd3b7f40a7ebe8d7a940f52
https://doi.org/10.1021/jm00172a032

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Evolution of the 4-anilidopiperidine class of opioid analgesics

Autor: Mark J. Benvenga, Richard L Wynn, John A. Colapret, Michael H. Ossipov, Theodore C. Spaulding, Nhora Lucia Lalinde, Frieda G. Rudo, Jerome R. Bagley, Bao-Shang Huang, Bor-Sheng Lin, Thomas P. Jerussi, Linas V. Kudzma, Brian M. Doorley, Spencer H Kenneth

Publikováno v: Medicinal research reviews. 11(4)

The findings reviewed herein have been the results of a five-year project undertaken by Anaquest to discover new therapeutically superior analgesics. The need to provide an analgesic for severe to moderate pain in the perioperative and nonsurgical en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df53c38c2f926282b72a17017699d966
https://pubmed.ncbi.nlm.nih.gov/1875771

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New 4-(heteroanilido)piperidines, structurally related to the pure opioidagonist fentanyl, with agonist and/or antagonist properties

Autor: B. M. Doorley, J. R. Bagley, Frieda G. Rudo, H. K. Spencer, Theodore C. Spaulding, R. L. Wynn

Publikováno v: Journal of Medicinal Chemistry. 32:663-671

A research program based on certain heterocyclic modifications (12-50) of the fentanyl (1) molecule has generated a novel class of opioids. In the mouse hot-plate test, these compounds were weaker analgesics than 1. Two types of antagonists were obse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9dfa6e13dd177be45ef1443d649851
https://doi.org/10.1021/jm00123a028

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Antinociceptive activity of clonidine and its potentiation of morphine analgesia

Autor: Harbans Lal, Joseph J. Venafro, Stuart Fielding, Theodore C. Spaulding

Publikováno v: European Journal of Pharmacology. 58:19-25

The activity of clonidine and its interaction with morphine was assesed in the mouse tail flick assay. In this assay, clonidine was found to be 10 times more potent than morphine. Clonidine potentiated morphine antinociceptive activity approximately

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffe3b8a1b185009e123276f192e72de
https://doi.org/10.1016/0014-2999(79)90335-2

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