Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Theodore C White"'
Autor:
Christopher B Ford, Jason M Funt, Darren Abbey, Luca Issi, Candace Guiducci, Diego A Martinez, Toni Delorey, Bi yu Li, Theodore C White, Christina Cuomo, Reeta P Rao, Judith Berman, Dawn A Thompson, Aviv Regev
Publikováno v:
eLife, Vol 4 (2015)
Candida albicans is both a member of the healthy human microbiome and a major pathogen in immunocompromised individuals. Infections are typically treated with azole inhibitors of ergosterol biosynthesis often leading to drug resistance. Studies in cl
Externí odkaz:
https://doaj.org/article/24a30f36045c4e68b7ec1778825dc6ed
Autor:
Sarah L Maguire, Can Wang, Linda M Holland, François Brunel, Cécile Neuvéglise, Jean-Marc Nicaud, Martin Zavrel, Theodore C White, Kenneth H Wolfe, Geraldine Butler
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004076 (2014)
In most eukaryotes, including the majority of fungi, expression of sterol biosynthesis genes is regulated by Sterol-Regulatory Element Binding Proteins (SREBPs), which are basic helix-loop-helix transcription activators. However, in yeasts such as Sa
Externí odkaz:
https://doaj.org/article/1db48e528ded4c038b6a3303d2962b9c
Publikováno v:
PLoS Pathogens, Vol 8, Iss 3, p e1002564 (2012)
Externí odkaz:
https://doaj.org/article/4019aeb5cb464435a8e72341f90ace67
Autor:
Bryce E Mansfield, Hanna N Oltean, Brian G Oliver, Samantha J Hoot, Sarah E Leyde, Lizbeth Hedstrom, Theodore C White
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001126 (2010)
Despite the wealth of knowledge regarding the mechanisms of action and the mechanisms of resistance to azole antifungals, very little is known about how the azoles are imported into pathogenic fungal cells. Here the in-vitro accumulation and import o
Externí odkaz:
https://doaj.org/article/8505fe346dc4439c807925fc429662f3
Autor:
Theodore C. White, Brooke D. Esquivel, Elisa M. Rouse Salcido, Allison M. Schweiker, Amanda R. dos Santos, Lalitha Gade, Erin Petro, Butch KuKanich, Kate S. KuKanich
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Candida auris is an emerging human fungal pathogen, first described in Japan in 2009, and first detected in the United States in 2016. Here, we report the first-ever description of C. auris colonizing a human pet, the first identification of
Externí odkaz:
https://doaj.org/article/ba6a450c4045438ba5ab0855e1be955a
Autor:
Brooke D. Esquivel, Elisa M. Rouse Salcido, Allison M. Schweiker, Brandon L. Holder, Butch KuKanich, Kate S. KuKanich, Theodore C. White
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
The purpose of this study was to characterize the variety and diversity of the oral mycobiome of domestic dogs and to identify the commensal and potentially pathogenic fungi present. Two hundred fifty-one buccal swabs from domestic dogs were obtained
Externí odkaz:
https://doaj.org/article/f899bb12c1244d4182ad58f3216e33cc
Autor:
Sonam Kumari, Mohit Kumar, Brooke D. Esquivel, Mohd Wasi, Ajay Kumar Pandey, Nitesh Kumar Khandelwal, Alok K. Mondal, Theodore C. White, Rajendra Prasad, Naseem A. Gaur
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT In this study, 18 predicted membrane-localized ABC transporters of Candida glabrata were deleted individually to create a minilibrary of knockouts (KO). The transporter KOs were analyzed for their susceptibility toward antimycotic drugs. Alt
Externí odkaz:
https://doaj.org/article/f10bed7c48c4410ea6c6ada83ec2dc52
Autor:
Garima Shahi, Mohit Kumar, Nitesh Kumar Khandelwal, Atanu Banerjee, Parijat Sarkar, Sonam Kumari, Brooke D. Esquivel, Neeraj Chauhan, Amitabha Chattopadhyay, Theodore C. White, Naseem A. Gaur, Ashutosh Singh, Rajendra Prasad
Publikováno v:
Journal of Fungi, Vol 8, Iss 7, p 651 (2022)
In this study, we have specifically blocked a key step of sphingolipid (SL) biosynthesis in Candida glabrata by disruption of the orthologs of ScIpt1 and ScSkn1. Based on their close homology with S. cerevisiae counterparts, the proteins are predicte
Externí odkaz:
https://doaj.org/article/042d099b74d3401890bb9f48bc56b6e7
Autor:
Jeffrey M. Rybak, José F. Muñoz, Katherine S. Barker, Josie E. Parker, Brooke D. Esquivel, Elizabeth L. Berkow, Shawn R. Lockhart, Lalitha Gade, Glen E. Palmer, Theodore C. White, Steve L. Kelly, Christina A. Cuomo, P. David Rogers
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown wh
Externí odkaz:
https://doaj.org/article/57743729eb0c454497ebc0dcd700562d
Autor:
Brooke D. Esquivel, Jeffrey M. Rybak, Katherine S. Barker, Jarrod R. Fortwendel, P. David Rogers, Theodore C. White
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT This research analyzed six Aspergillus fumigatus genes encoding putative efflux proteins for their roles as transporters. The A. fumigatus genes abcA, abcC, abcF, abcG, abcH, and abcI were cloned into plasmids and overexpressed in a Saccharo
Externí odkaz:
https://doaj.org/article/d8fc063efb164397b16c0f643c17c6f3