CSF rhinorrhoea after endonasal intervention to the skull base (CRANIAL): A multicentre prospective observational study

Autor: CRANIAL Consortium, Danyal Z Khan, Hani J Marcus, Soham Bandyopadhyay, Benjamin E Schroeder, Vikesh Patel, Alice O’Donnell, Neurology and Neurosurgery Interest Group, British Neurosurgical Trainee Research Collaborative, Anastasios Giamouriadis, Pragnesh Bhatt, Bhaskar Ram, Adithya Varma, Philip Weir, Brendan Hanna, Theodore C Hirst, Patrick McAleavey, Alessandro Paluzzi, Georgios Tsermoulas, Shahzada Ahmed, Wai Cheong Soon, Yasir Arafat Chowdhury, Suhaib Abualsaud, Shumail Mahmood, Paresh Naik, Zohra Haiderkhan, Rafid Al-Mahfoudh, Andrea Perera, Mircea Rus, Adam Williams, Charles Hand, Kumar Abhinav, Cristina Cernei, Aiman Dilnawaz, Richard Mannion, Thomas Santarius, James Tysome, Rishi Sharma, Angelos G Kolias, Neil Donnelly, Ashwin Venkatesh, Caroline Hayhurst, Amr Mohamed, Benjamin Stew, Joseph Merola, Setthasorn Zhi Yang Ooi, Mahmoud Kamel, Mohammad Habibullah Khan, Sahibzada Abrar, Christopher Mckeon, Daniel McSweeney, Mohsen Javadpour, Peter Lacy, Daniel Murray, Elena Roman, Kismet Hossain-Ibrahim, Peter Ross, David Bennett, Nathan McSorley, Adam Hounat, Patrick Statham, Mark Hughes, Alhafidz Hamdan, Caroline Scott, Jigi Moudgil-Joshi, Anuj Bahl, Anna Bjornson, Daniel Gatt, Nick Phillips, Neeraj Kalra, Melissa Bautista, Seerat Shirazi, Catherine E Gilkes, Christopher P Millward, Ahmad MS Ali, Dimitris Paraskevopoulos, Jarnail Bal, Samir Matloob, Rhannon Lobo, Nigel Mendoza, Ramesh Nair, Arthur Dalton, Adarsh Nadig, Lucas Hernandez, Nick Thomas, Eleni Maratos, Jonathan Shapey, Sinan Al-Barazi, Asfand Baig Mirza, Mohamed Okasha, Prabhjot Singh Malhotra, Razna Ahmed, Neil L Dorward, Joan Grieve, Parag Sayal, David Choi, Ivan Cabrilo, Hugo Layard Horsfall, Jonathan Pollock, Alireza Shoakazemi, Oscar Maccormac, Guru N K Amirthalingam, Andrew Martin, Simon Stapleton, Florence Hogg, Daniel Richardson, Kanna Gnanalingham, Omar Pathmanaban, Daniel M Fountain, Raj Bhalla, Cathal J Hannan, Annabel Chadwick, Alistair Jenkins, Claire Nicholson, Syed Shumon, Mohamed Youssef, Callum Allison, Graham Dow, Iain Robertson, Laurence Johann Glancz, Murugan Sitaraman, Ashwin Kumaria, Ananyo Bagchi, Simon Cudlip, Jane Halliday, Rory J Piper, Alexandros Boukas, Meriem Amarouche, Damjan Veljanoski, Samiul Muquit, Ellie Edlmann, Haritha Maripi, Yi Wang, Mehnaz Hossain, Andrew Alalade, Syed Maroof, Pradnya Patkar, Saurabh Sinha, Showkat Mirza, Duncan Henderson, Mohammad Saud Khan, Nijaguna Mathad, Jonathan Hempenstall, Difei Wang, Department of Neurosurgery, Pavan Marwaha, Simon Shaw, Georgios Solomou, Alina Shrestha, Andrew Fraser, Theodore Hirst, Yasir Chowdhury, Sobiya Bilal, Jack Wildman, Priya Babu, Cian Carey, Renitha Reddi Bathuni, Joseph Nathaniel Brennan, Howra Ktayen, Sandhya T Trichinopoly, Danyal Khan, Seun Sobawale, Amir Suliman, Rory Piper, Will Owen, Afaq Sartaj, Edward Goacher, Euan Strachan, Giorgios Solomou

Publikováno v: Frontiers in Oncology, Vol 12 (2023)

ObjectiveDespite progress in endonasal skull-base neurosurgery, cerebrospinal fluid (CSF) rhinorrhoea remains common and significant. The CRANIAL study sought to determine 1) the scope of skull-base repair methods used, and 2) corresponding rates of

Externí odkaz: https://doaj.org/article/3d637f013daa4d23b8a1216e324eb58a

The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis.

Autor: Jiarong Chen, Canhong Yang, Bin Guo, Emily S Sena, Malcolm R Macleod, Yawei Yuan, Theodore C Hirst

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0158240 (2016)

BACKGROUND:Breast cancer is the most frequent cancers and is the second leading cause of cancer death among women. Trastuzumab is an effective treatment, the first monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER

Externí odkaz: https://doaj.org/article/13b099cc261c43c5989cfdbe96708850

A Systematic Review and Meta-Analysis of Hypothermia in Experimental Traumatic Brain Injury: Why Have Promising Animal Studies Not Been Replicated in Pragmatic Clinical Trials?

Autor: Theodore C. Hirst, Malcolm R. Macleod, Peter J. D. Andrews, Max G Klasen, Jonathan Rhodes

Publikováno v: Journal of Neurotrauma

Therapeutic hypothermia was a mainstay of severe traumatic brain injury (TBI) management for half a century. Recent trials have suggested that its effect on long-term functional outcome is neutral or negative, despite apparently promising pre-clinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856bb2ba5985b1446812e3da30aadfa9
https://pubmed.ncbi.nlm.nih.gov/32394804

Extent of resection in glioblastoma: a 10-year local survival analysis

Autor: Patrick McAleavey, Tom Flannery, Theodore C. Hirst

Publikováno v: Neuro-Oncology. 23:iv19-iv19

Aims The impact on extent of resection (EOR) in glioblastoma has been well documented. It is clear that gross-total resection (GTR) confers best overall survival (OS), however the minimum EOR required to confer a survival benefit over biopsy is debat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e4446aaf63e277e0e132193ad58c57f
https://doi.org/10.1093/neuonc/noab195.049

Segmentation of the mouse fourth deep lumbrical muscle connectome reveals concentric organisation of motor units

Autor: Richard R. Ribchester, Theodore C. Hirst

Publikováno v: The Journal of Physiology. 591:4859-4875

Connectomic analysis of the nervous system aims to discover and establish principles that underpin normal and abnormal neural connectivity and function. Here we performed image analysis of motor unit connectivity in the fourth deep lumbrical muscle (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f0ed529910c2acddfbd93b6a4e31775
https://doi.org/10.1113/jphysiol.2013.258087