Výsledky vyhledávání - "Theodore A.G. Smith"

A Novel Glycomimetic Compound (GMI-1757) with Dual Functional Antagonism to E-Selectin and Galectin-3 Demonstrates Inhibition of Thrombus Formation in an Inferior Vena Cava Model

Autor: Daniel D. Myers, Peterson John M, Silvia Locatelli-Hoops, Jiwon Lee, Theodore A.G. Smith, William E. Fogler, Yusuf Vohra, John L. Magnani, Lingquan Deng

Publikováno v: Blood. 132:2211-2211

E-selectin functions in venous thrombosis by binding and activating host cells to initiate the coagulation cascade. The E-selectin antagonist, Uproleselan (GMI-1271), has been shown to attenuate thrombus formation following electrical stimulation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b864220595ebff91dfa63be61aabe0f1
https://doi.org/10.1182/blood-2018-99-118122

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A Novel and Potent Inhibitor of E-Selectin, GMI-1687, Attenuates Thrombus Formation and Augments Chemotherapeutic Intervention of AML in Preclinical Models Following Subcutaneous Administration

Autor: Daniel D. Myers, Myung-Gi Baek, Silvia Locatelli-Hoops, Lingquan Deng, David Stewart, Jiwon Lee, Peterson John M, Theodore A.G. Smith, William E. Fogler, John L. Magnani

Publikováno v: Blood. 132:4678-4678

Uproleselan (GMI-1271), an E-selectin antagonist, has been shown in preclinical models to disrupt activation of cell survival pathways in acute myeloid leukemia (AML), enhance chemotherapy efficacy, and improve survival. Uproleselan received FDA brea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5928cbf5225c6bfaf78f002fec08d76
https://doi.org/10.1182/blood-2018-99-116779

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Abstract 2867: Glycomimetic antagonist of E-selectin, GMI-1271, enhances therapeutic activity of the hypomethylating agent 5-azacitidine in the KG1 model of AML

Autor: John L. Magnani, Theodore A.G. Smith, William E. Fogler, Jiwon Lee

Publikováno v: Cancer Research. 78:2867-2867

Binding of AML blasts to E-selectin activates cellular survival pathways leading to chemoresistance. GMI-1271 is a novel E-selectin antagonist that when used in combination with chemotherapy results in improved survival in mouse syngeneic and xenogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73e3ca97f718246a358fde39bad7aabf
https://doi.org/10.1158/1538-7445.am2018-2867

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Abstract 1757: Mobilization of tumor-primed, marrow-infiltrating lymphocytes into peripheral blood with inhibitors of E-selectin or E-selectin and CXCR4

Autor: William E. Fogler, John L. Magnani, Rachel K. King, Theodore A.G. Smith

Publikováno v: Cancer Research. 78:1757-1757

Marrow-infiltrating lymphocytes (MILs) primed to tumor antigens have been described in patients with hematologic malignancies and in metastatic disease arising from carcinomas. The presence of tumor-reactive MILs in these patients has suggested the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5dec563325d4c68662eb753d17f45487
https://doi.org/10.1158/1538-7445.am2018-1757

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Abstract 5005: Inhibition of E-selectin or E-selectin together with CXCR4 resensitizes multiple myeloma to treatment

Autor: Anita Sekula, William E. Fogler, John L. Magnani, Henna Y. Bazai, Abdel Kareem Azab, Barbara Muz, Theodore A.G. Smith

Publikováno v: Cancer Research. 77:5005-5005

INTRODUCTION: Multiple myeloma (MM) is a plasma cell malignancy localized in the bone marrow. Selectins and CXCR4 play a pivotal role in homing, adhesion, and proliferation of MM. Herein, we tested the role of E-selectin in the pathophysiology of MM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ba3504edab9126b0cfc148ae4b5957c
https://doi.org/10.1158/1538-7445.am2017-5005

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Mobilization of CD8+ Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade

Autor: Kristen J. Radford, Valerie Barbier, Ingrid G. Winkler, Theodore A.G. Smith, William E. Fogler, Jean-Pierre Levesque, John L. Magnani, Julie M. Davies

Publikováno v: ResearcherID

T-cells are critical mediators of immune defense against pathogens and cancer. Adoptive T cell immunotherapy and T-cell engineering have promising clinical applications but T cell survival and exhaustion are current limitations. Central memory cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7937e42cee6beb9f423de6462738b68
https://doi.org/10.1182/blood.v126.23.512.512

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E-Selectin Ligand Expression Increases with Progression of Myeloma and Induces Drug Resistance in a Murine Transplant Model, Which Is Overcome By the Glycomimetic E-Selectin Antagonist, GMI-1271

Autor: Theodore A.G. Smith, Niamh Keane, Michael O'Dwyer, Silvia Locatelli-Hoops, William E. Fogler, Alessandro Natoni, John L. Magnani, Isabela Oliva

Publikováno v: Web of Science

There is increasing evidence that E-selectin and its ligands play an important role in the progression of multiple myeloma (MM) and drug resistance. We reported that the sialyltransferase ST3GAL6 influences homing and survival in MM, and postulated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331c553aff217f289900d1a83fde357f
https://doi.org/10.1182/blood.v126.23.1805.1805

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Role of Selectins in the Pathogenesis of Multiple Myeloma

Autor: Molly R. Melhem, Irene M. Ghobrial, Phong Quang, Aldo M. Roccaro, Judith Runnels, Antonio Sacco, Costas Pitsillides, Arun K. Sarkar, Charles P. Lin, Kenneth C. Anderson, Feda Azab, John T. Patton, Theodore A.G. Smith, John L. Magnani, Abdel Kareem Azab, Hai T. Ngo, Patricia Maiso

Publikováno v: Blood. 114:951-951

Abstract 951 INTRODUCTION: Multiple Myeloma (MM) is characterized by widespread disease at diagnosis with the presence of multiple lytic lesions and disseminated involvement of the bone marrow (BM), implying that the progression of MM involves a cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::423a10d5cea65cdcb48ae042f58e0fb6
https://doi.org/10.1182/blood.v114.22.951.951

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Pan-Selectin Inhibitor GMI-1070 Blocks Cell Adhesion of Acute Myelogenous Leukemia Cell Lines

Autor: John T. Patton, Theodore A.G. Smith, John L. Magnani, Leonard D. Shultz

Publikováno v: Blood. 112:4039-4039

Most patients with acute myelogenous leukemia (AML) initially respond to chemotherapy but later relapse and die from the disease (50–70%). One mechanism by which AML cells resist treatment with anti-proliferative drugs is by cell adhesion in protec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe08e382b8ab6e16f45dbd326542352e
https://doi.org/10.1182/blood.v112.11.4039.4039

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