Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Theodora R. Devereux"'
Autor:
Hue-Hua L. Hong, Ronald A. Herbert, June Dunnick, Theodora R. Devereux, Robert C. Sills, Yongbaek Kim
Publikováno v:
Environmental and Molecular Mutagenesis. 48:299-306
A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1) mice to 0, 50, 100, 200, or 300 mg of 3′-azido-3′-deoxythymidine (AZT)/kg bw/day, through a 18 to 19-day gestation [National Toxicology Program, NIH Pub. No. 0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857919c3c980ac3fba03352275a17d00
https://doi.org/10.1002/em.20197
https://doi.org/10.1002/em.20197
Publikováno v:
Toxicologic Pathology. 35:75-80
Lung cancer is the leading cause of cancer death worldwide, and the need to develop better diagnostic techniques and therapies is urgent. Mouse models have been utilized for studying carcinogenesis of human lung cancers, and many of the major genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18236a6196ac973ab8c3b25709521bb5
https://doi.org/10.1080/01926230601059993
https://doi.org/10.1080/01926230601059993
Autor:
Theodora R. Devereux, Robert C. Sills, Natasha P. Clayton, Ronald L. Melnick, Yan Lachat, Monika E. Hegi, Yongbaek Kim, Hue-Hua L. Hong
Publikováno v:
Toxicologic Pathology. 33:307-312
The nervous system of the B6C3F1 mouse has rarely been a target for chemical carcinogenesis in the National Toxicology Program (NTP) bioassays. However, 6 malignant gliomas and 2 neuroblastomas were observed in B6C3F1 mice exposed to 625 ppm 1,3-buta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927c49841dba07924a5af6533cea5bac
https://doi.org/10.1080/01926230590922848
https://doi.org/10.1080/01926230590922848
Autor:
Theodora R. Devereux, Scott D. McCulloch, Ming You, Min Wang, Thomas A. Kunkel, Colleen H. Anna, Yian Wang, Haris G. Vikis, Wanda Holliday, Kun-Liang Guan, Katarzyna Bebenek
Publikováno v:
Cancer Research. 64:1924-1931
In this study, we performed systematic candidate gene analyses of the Pulmonary adenoma resistance 2 locus. Differential gene expression in lung tissues and nucleotide polymorphisms in coding regions between A/J and BALB/cJ mice were examined using r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ca841e554aece607c665f5b40e5eb9
https://doi.org/10.1158/0008-5472.can-03-3080
https://doi.org/10.1158/0008-5472.can-03-3080
Autor:
Natasha P. Clayton, June K. Dunnick, Po-Chuen Chan, Cindy R. Moomaw, Theodora R. Devereux, Robert C. Sills, T. V. Ton, Hue-Hua L. Hong
Publikováno v:
Toxicology and Applied Pharmacology. 191:227-234
The most prominent neoplastic lesions in mice in the 2-year studies of o -nitrotoluene and riddelliine were hemangiosarcomas. Fifteen o -nitrotoluene-induced hemangiosarcomas of the skeletal muscle, subcutaneous tissue, and mesentery; 12 riddelliine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f52dcafe113cdc00f11f8d3e583181
https://doi.org/10.1016/s0041-008x(03)00165-0
https://doi.org/10.1016/s0041-008x(03)00165-0
Publikováno v:
Toxicology and Applied Pharmacology. 190:135-145
In this study we used liver neoplasms induced by several chemical carcinogens to investigate potential nuclear targets associated with beta-catenin/Wnt signaling and potential membrane-associated beta-catenin binding partners. Strong expression of cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cf5765893c2e106f063fe41a535f70
https://doi.org/10.1016/s0041-008x(03)00170-4
https://doi.org/10.1016/s0041-008x(03)00170-4
Autor:
Joseph H. Roycroft, Nancy Ress, Theodora R. Devereux, Colleen H. Anna, Wanda Holliday, Robert C. Sills
Publikováno v:
Carcinogenesis. 23:1737-1743
Previous work showed a correlation between K-ras mutation and loss of heterozygosity (LOH) on chromosome 6 in the region of K-ras in lung carcinomas from B6C3F1 mice. We hypothesized that mitogen-activated protein kinase (MAPK) would be activated onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29aee6fdee8bfb58a10bbb988db3f940
https://doi.org/10.1093/carcin/23.10.1737
https://doi.org/10.1093/carcin/23.10.1737
Autor:
Marshall W. Anderson, Hue-Hua L. Hong, Theodora R. Devereux, Gongjie Liu, Jie Li, Tyler Jacks, Kun-Liang Guan, Ming You, Leisa Johnson, Haris G. Vikis, Robert C. Sills, Yian Wang, Zhongqiu Zhang
Publikováno v:
Nature Genetics. 29:25-33
Although the ras genes have long been established as proto-oncogenes, the dominant role of activated ras in cell transformation has been questioned. Previous studies have shown frequent loss of the wildtype Kras2 allele in both mouse and human lung a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac49a8617f05c2d206ead0476a41f1a
https://doi.org/10.1038/ng721
https://doi.org/10.1038/ng721
Publikováno v:
Chemico-Biological Interactions. :373-386
1,3 Butadiene (BD), isoprene (IP) and chloroprene (CP) are structural analogs. There were significantly increased incidences of forestomach neoplasms in B6C3F1 mice exposed to BD, IP or CP by inhalation for up to 2-years. The present study was design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37de4350d1acb56351c11e1c1accda5c
https://doi.org/10.1016/s0009-2797(01)00179-x
https://doi.org/10.1016/s0009-2797(01)00179-x
Autor:
Jack A. Taylor, Theodora R. Devereux, Zhen-Quan Zhang, Mimi C. Yu, Gordon P. Flake, Mariana C. Stern, Stephanie J. London
Publikováno v:
Molecular Carcinogenesis. 31:68-73
beta-Catenin plays a key role in the Wnt signaling pathway, and mutations of CTNNB1, the gene that encodes beta-catenin, have been identified in about one-fourth of human hepatocellular carcinomas from regions of low aflatoxin B1 exposure. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3eb9b9e5f68fc292bad8bb7411e7c41
https://doi.org/10.1002/mc.1041
https://doi.org/10.1002/mc.1041