Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Theodora Nikolova"'
Autor:
Bernd Kaina, Nancy Berte, Mengwan Wang, Kerstin Borgmann, Theodora Nikolova, Andrea Piee-Staffa, Nadine Piecha
Publikováno v:
Molecular Cancer Therapeutics. 15:2665-2678
Malignant gliomas exhibit a high level of intrinsic and acquired drug resistance and have a dismal prognosis. First- and second-line therapeutics for glioblastomas are alkylating agents, including the chloroethylating nitrosoureas (CNU) lomustine, ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25e5127f4f48f68a304fcf9b0acf33f
https://doi.org/10.1158/1535-7163.mct-16-0176
https://doi.org/10.1158/1535-7163.mct-16-0176
Publikováno v:
Molecular cancer therapeutics. 12(11)
The major cytotoxic DNA adduct induced by temozolomide and other methylating agents used in malignant glioma and metastasized melanoma therapy is O6-methylguanine (O6-MeG). This primary DNA damage is converted by mismatch repair into secondary lesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21732e014f0dc3482f7728ab5c1bd591
https://pubmed.ncbi.nlm.nih.gov/23960094
https://pubmed.ncbi.nlm.nih.gov/23960094
Publikováno v:
Molecular cancer therapeutics. 10(12)
Artesunate, the active agent from Artemisia annua L. used in the traditional Chinese medicine, is being applied as a first-line drug for malaria treatment, and trials are ongoing that include this drug in cancer therapy. Despite increasing interest i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f96c0fcfa80a544704770d884647b02
https://pubmed.ncbi.nlm.nih.gov/21998290
https://pubmed.ncbi.nlm.nih.gov/21998290