Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Theodor W Schulte"'
Autor:
Sreenath V. Sharma, Junichi Kurebayashi, Shiro Akinaga, Yoji Ikuina, Leonard M. Neckers, Tatsuya Tamaoki, Yukimasa Shiotsu, Chikara Murakata, Harunobu Tahara, Theodor W. Schulte, Shiro Soga, Makiko Shimizu, Kazuo Yamaguchi
Publikováno v:
Cancer Chemotherapy and Pharmacology. 48:435-445
Purpose: Radicicol is a novel hsp90 antagonist, distinct from the chemically unrelated benzoquinone ansamycin compounds, geldanamycin and herbimycin. Both geldanamycin and radicicol bind in the aminoterminal nucleotide-binding pocket of hsp90, destab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83cd4cf140fc0b917ce62e04cf32c49
https://doi.org/10.1007/s002800100373
https://doi.org/10.1007/s002800100373
Autor:
Mikhail V. Blagosklonny, Benjamin Knepper, Jane B. Trepel, J. Frederic Mushinski, Olaf Schaefer, Farzaneh Pirnia, Maria Tsokos, Jung Sik Kim, Yung Hyun Choi, Michael J. Birrer, Phuong Mai Nguyen, Theodor W. Schulte
Publikováno v:
Oncogene. 19:6082-6090
To develop a new approach to the treatment of primitive neuroectodermal tumors we evaluated the effect of the HMG-CoA reductase inhibitor lovastatin on the Ewing's sarcoma cell line CHP-100. Lovastatin induced neural morphology and markers including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed6c12e53a09c27ba43c772fdbb0418
https://doi.org/10.1038/sj.onc.1204008
https://doi.org/10.1038/sj.onc.1204008
Publikováno v:
Drug Resistance Updates. 2:165-172
Heat shock protein 90 is one of the most abundant cellular proteins. Although its functions are still being characterized, it appears to serve as a chaperone for a growing list of cell signaling proteins, including many tyrosine and serine/threonine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e804940879076259d30e76cf5e2f54b2
https://doi.org/10.1054/drup.1999.0082
https://doi.org/10.1054/drup.1999.0082
Publikováno v:
Molecular Genetics and Metabolism. 66:24-30
FAK is a nonreceptor tyrosine kinase involved in adhesion-mediated signal transduction whose level of expression is related to the invasiveness of malignant tumors. In seeking strategies to downregulate FAK, we treated various cell lines in vitro wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed9a5d54c32517f8085505b957a5647
https://doi.org/10.1006/mgme.1998.2774
https://doi.org/10.1006/mgme.1998.2774
Autor:
Leonard M. Neckers, Theodor W. Schulte
Publikováno v:
Cancer Chemotherapy and Pharmacology. 42:273-279
Purpose: Benzoquinone ansamycins are antibiotics with anticancer potential. First described as tyrosine kinase inhibitors, they are now frequently used to target HSP90 chaperone function. While herbimycin A and geldanamycin (GA) have been widely used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227c63e838cdd8bbabdde5559c9a7527
https://doi.org/10.1007/s002800050817
https://doi.org/10.1007/s002800050817
Publikováno v:
Biochemical and Biophysical Research Communications. 239:655-659
The Raf-1-MEK-MAPK pathway plays an important role in transducing extracellular growth factor signaling into altered nuclear transcription factor function. The benzoquinone ansamycin Geldanamycin (GA) specifically binds to the heat shock protein HSP9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cdb3dab418d72a4468223233b55e9e
https://doi.org/10.1006/bbrc.1997.7527
https://doi.org/10.1006/bbrc.1997.7527
Autor:
Leonard M. Neckers, Jenny Clark, Theodor W. Schulte, David O. Toft, William P. Sullivan, Hans Joachim Ochel, Timothy A.J. Haystead, Patrick Fadden, James P. Grenert, Edward A. Sausville, Henry C. Krutzsch, Edward G. Mimnaugh
Publikováno v:
Journal of Biological Chemistry. 272:23843-23850
Many functions of the chaperone, heat shock protein 90 (hsp90), are inhibited by the drug geldanamycin that specifically binds hsp90. We have studied an amino-terminal domain of hsp90 whose crystal structure has recently been solved and determined to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55e2446bd75c5ed1248435178c5f9b5
https://doi.org/10.1074/jbc.272.38.23843
https://doi.org/10.1074/jbc.272.38.23843
Publikováno v:
Biochemical and Molecular Medicine. 60:121-126
The Ewing's sarcoma family of tumors (ESFT) is the second most common pediatric malignancy originating in the bone and is characterized by the t(11; 22) translocation. PAX3, a member of the paired box family of genes, is expressed during embryonal de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232a2f0eddc4c52026183a970a9929cb
https://doi.org/10.1006/bmme.1997.2567
https://doi.org/10.1006/bmme.1997.2567
Autor:
Yukimasa Shiotsu, Ivo Wortman, Theodor W. Schulte, Shiro Soga, Leonard M. Neckers, Chikara Murakata, Tatsuya Tamaoki, Shiro Akinaga, Won G. An
Publikováno v:
Blood. 96(6)
Chronic myelogenous leukemia (CML) is a clonal disorder of a pluripotent hematopoietic stem cells characterized by a chimericbcr-abl gene giving rise to a p210Bcr-Ablprotein with dysregulated tyrosine kinase activity. Radicicol, a macrocyclic antifun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ef5dc83dcda58fcf8ebfc810e0fdc5
https://pubmed.ncbi.nlm.nih.gov/10979978
https://pubmed.ncbi.nlm.nih.gov/10979978