Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Theocharis V. Koftis"'
Autor:
Christos I. Stathakis, John K. Gallos, Stavroula A. Zisopoulou, Thanos Andreou, Theocharis V. Koftis
Publikováno v:
Synthesis. 55:1507-1516
A novel, conceptually distinct synthesis of a key precursor to sacubitril, an antihypertensive drug, is presented. The well-demonstrated hetero-Diels–Alder addition of in situ generated nitrosoalkenes to electron-rich enol ethers was engaged to est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e79c8e6e08950428f26831a089373c
https://doi.org/10.1055/a-2029-0015
https://doi.org/10.1055/a-2029-0015
Autor:
Nicolaos S. Iordanidis, Alexandros L. Zografos, Christos I. Stathakis, John K. Gallos, Theocharis V. Koftis
Publikováno v:
European Journal of Organic Chemistry. 2021:5058-5062
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36707d778973084cac16b5c5325be1c9
https://doi.org/10.1002/ejoc.202100912
https://doi.org/10.1002/ejoc.202100912
Autor:
Olga G. Mountanea, Kyriaki-Eleni C. Papoulidou, Theocharis V. Koftis, Thanos Andreou, John K. Gallos, Virginia V. Triantakonstanti
Publikováno v:
Tetrahedron. 74:5700-5708
A new method for the diastereoselective synthesis of enantiomerically pure ertugliflozin was developed. The crucial step involves an aldol condensation between 1-(4-chloro-3-(4-ethoxybenzyl)phenyl)ethanone and (4R,5R)-5-(((tert-butyldimethylsilyl)oxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::658b37f04d9ec9100a8dbbf8befe05c6
https://doi.org/10.1016/j.tet.2018.08.005
https://doi.org/10.1016/j.tet.2018.08.005
Autor:
Theodoros Panagiotidis, Efthymia G. Gioti, Evanthia P. Tolika, Anastasia-Aikaterini Varvogli, Stefanos S. Kotoulas, Thanos Andreou, John K. Gallos, Efstratios Neokosmidis, Theocharis V. Koftis, Theodoros Tsatsas, Sakellarios Trakossas, Elli Vastardi, Constantinos K. Zacharis, Elizabeth E. Anagnostaki
Publikováno v:
Tetrahedron. 74:519-527
A new synthesis of entecavir from d -glucose in an average total yield of 3.5% was achieved via an intramolecular nitrile oxide cycloaddition (INOC) reaction and a Peterson olefination as key-steps. The present process was designed for industrial app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::010cdbad7486038f6a6b777f3e2bd3ef
https://doi.org/10.1016/j.tet.2017.12.034
https://doi.org/10.1016/j.tet.2017.12.034
Publikováno v:
European Journal of Organic Chemistry. 2014:6376-6379
A concise, scalable, and industrially applicable process for the synthesis of the antidepressant agomelatine is described. The process relies on a tandem allylic chlorination–isomerization sequence, on a tetralone-derived allyl carbinol, as the key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d50a8fd12919f6f0b34c60bdeb2a3ea5
https://doi.org/10.1002/ejoc.201402886
https://doi.org/10.1002/ejoc.201402886
Publikováno v:
ChemInform. 46
A concise, scalable, and industrially applicable process for the synthesis of the antidepressant agomelatine is described. The process relies on a tandem allylic chlorination–isomerization sequence, on a tetralone-derived allyl carbinol, as the key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12b08022aac24a993609ffa65ff2ca95
https://doi.org/10.1002/chin.201515286
https://doi.org/10.1002/chin.201515286
Autor:
Wenjun Tang, Michael O. Frederick, Theocharis V. Koftis, Kyriacos C. Nicolaou, Goran Petrovic, Emiko Ito, Taotao Ling
Publikováno v:
Harmful Algae. 5:586-591
Synthetic azaspiracid-1 (AZA-1, 1 ), 6-, 10-, 13-, 14-, 16-, 17-, 19-, 20- epi -azaspiracid-1 (C 1 –C 20 - epi -AZA-1, 2 ), and twelve truncated azaspiracid-1 analogs ( 3 – 14 ) were synthesized and tested for their toxicity effects in mice. Of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f4fc9d01c17aac2bf1da5be9f6f69cf
https://doi.org/10.1016/j.hal.2005.11.005
https://doi.org/10.1016/j.hal.2005.11.005
Autor:
Kyriacos C. Nicolaou, Theocharis V. Koftis, Yoichi M. A. Yamada, Michael O. Frederick, Eriketi Z. Loizidou, Goran Petrovic, Kevin P. Cole
Publikováno v:
Chemistry – An Asian Journal. 1:245-263
The naturally occurring but scarce marine neurotoxins azaspiracids-1, -2, and -3 have been synthesized from five key building blocks by a convergent strategy that involved dithiane and Stille coupling reactions. The ABCD fragments were constructed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce21483f99240c61bfe3a9b67ef1600e
https://doi.org/10.1002/asia.200600059
https://doi.org/10.1002/asia.200600059
Autor:
Anthony J. Roecker, Antonella Converso, Pradip K. Sasmal, Eriketi Z. Loizidou, Florian Kaiser, Goran Petrovic, Xiao-Wen Sun, Theocharis V. Koftis, Kyriacos C. Nicolaou, Constantinos C. Dellios
Publikováno v:
Angewandte Chemie International Edition. 44:3447-3452
The remarkable antifeedant agent and insecticide, azadirachtin (1), has, to date, escaped a total synthesis. The preparation of an advanced precursor has revealed some of the inner intricacies of this uniquely crowded and highly functionalized molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a9bcd931f4f60bbe0ee418dc2c7bab
https://doi.org/10.1002/anie.200500217
https://doi.org/10.1002/anie.200500217
Autor:
Taotao Ling, Michael O. Frederick, Wenjun Tang, Yoichi M. A. Yamada, Theocharis V. Koftis, Goran Petrovic, David Y.-K. Chen, Kyriacos C. Nicolaou, Yiwei Li, Stepan Vyskocil, Masayuki Satake
Publikováno v:
Angewandte Chemie. 116:4412-4418
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7413b70c4476d0726b7ffa2803ca83a3
https://doi.org/10.1002/ange.200460695
https://doi.org/10.1002/ange.200460695