Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Theo Zweifel"'
Autor:
Marvin M. Hansen, Jennifer Kuehne-Willmore, Amy C. DeBaillie, Molly Harding, Joseph R. Martinelli, Daniel J. Jarmer, Michael J. McCulley, Dominique Huber, Michael E. Laurila, Thomas J. Martin, David W. Hoard, Theo Zweifel, Ryan J. Linder, Stanley P. Kolis, Nikolay Zaborenko, Enver Arslantas, Rachel N. Richey, Derek R. Starkey, Thomas Kull, Adrienne Hollister, Jeffrey A. Ward, Andrea L. Frederick
Publikováno v:
Organic Process Research & Development. 19:1214-1230
An efficient synthesis of LY2886721 (1) in five steps and 46% overall yield from the chiral nitrone cycloadduct 2 is presented. Minimizing formation of a des-fluoro impurity during hydrogenolysis to cleave the isoxazolidine ring and remove the benzyl
Autor:
Lars Krogager Ransborg, Theo Zweifel, Karl Anker Jørgensen, Mette Overgaard, Łukasz Albrecht, Vibeke Henriette Lauridsen
Publikováno v:
Albrecht, L K, Ransborg, L K, Lauridsen, V, Overgaard, M K, Zweifel, T & Jørgensen, K A 2011, ' Taming the Friedel-Crafts Reaction – An Organocatalytic Approach to Optically Active 2,3-Dihydrobenzofurans ', Angewandte Chemie International Edition, vol. 50, no. 52, pp. 12496-12500 . https://doi.org/10.1002/anie.201105819
Fine-tuning: Three types of optically active trans-2,3-disubstituted-2,3-dihydrobenzofurans having three contiguous stereogenic centers can be efficiently accessed by one-pot reaction cascades (see scheme; TMS = trimethylsilyl). High substitution div
Autor:
Theo Zweifel, Karl Anker Jørgensen, Christian Borch Jacobsen, Dennis Worgull, Esben Fisker, Martin Nielsen
Publikováno v:
Jacobsen, C B, Nielsen, M, Worgull, D, Zweifel, T, Fisker, E & Jørgensen, K A 2011, ' Asymmetric organocatalytic monofluorovinylations ', Journal of the American Chemical Society, vol. 133, no. 19, pp. 7398-7404 . https://doi.org/10.1021/ja110624k
The development of highly enantio- and diastereoselective organocatalytic monofluorovinylations is presented. Based on the application of α-fluoro-β-keto-benzothiazolesulfones, the formal addition of a monofluorovinylic anion synthon to a range of
Publikováno v:
Zweifel, T, Nielsen, M, Overgaard, J, Jacobsen, C B & Jørgensen, K A 2011, ' Practical Synthesis of β-Carbonyl Phenyltetrazolesulfones and Investigations of Their Reactivities in Organocatalysis ', European Journal of Organic Chemistry, vol. 2011, no. 1, pp. 47-52 . https://doi.org/10.1002/ejoc.201001426
A practical synthesis of β-carbonyl phenyltetrazolesulfones, useful for a series of enantioselective reactions, is shown. Aryl, alkyl and ester carbonyl compounds all proved to be efficiently synthesised, leading to products in up to >99 % yield ove
Publikováno v:
CHEMCATCHEM
The amino diolefin complex [Rh(trop 2 NH)(TMIY)] + (OTf) (OTf - = CF 3 SO 3 - ; trop=5-H-dibenzo[a,d]cyclohepten-5yl), incorporating N-heterocyclic carbene ligand 1,3,4,5-tetramethylimidazole-2-ylidene (TMIY), has been prepared. The structure is dete
Publikováno v:
European Journal of Inorganic Chemistry. 2009:5561-5576
Bis(olefin)amines (boas) are a new class of ligands for the synthesis of transition metal complexes, which can be used in various homogeneous catalytic reactions. A simple straightforward coupling reaction between 5H-dibenzo[a,d]cyclohepten-5-yl chlo
Publikováno v:
Angewandte Chemie International Edition. 48:559-563
A working partnership: Metal-ligand cooperativity is responsible for the high activity of the rhodium amido complex 1 in the dehydrogenative coupling of primary alcohols with water, methanol, or amines, including ammonia (see scheme), to give carboxy
Publikováno v:
Angewandte Chemie. 120:3289-3293
Autor:
Mette Overgaard, Lars Krogager Ransborg, Vibeke Henriette Lauridsen, Lukasz Albrecht, Karl Anker Joergensen, Theo Zweifel
Publikováno v:
ChemInform. 43
Diversity-orientated one-pot reaction cascades are reported for the preparation of chiral trans-2,3-disubstituted title compounds having three contiguous stereocenters.
Autor:
Esben Fisker, Christian Borch Jacobsen, Karl Anker Joergensen, Theo Zweifel, Martin Nielsen, Dennis Worgull
Publikováno v:
ChemInform. 42
Depending on catalyst and reducing agent used, selective formation of (R)- or (S)- and (E)- or (Z)-configurated products is possible.