Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Theo Thepen"'
Publikováno v:
Antibodies, Vol 3, Iss 1, Pp 92-115 (2014)
Targeted therapies for the treatment of cancer, but also inflammation and autoimmune diseases will reduce major side effects accompanied with conventional treatment modalities. The immunotoxin concept uses bacterial or plant toxins, coupled to antibo
Externí odkaz:
https://doaj.org/article/8141487616654464844d211b75b116a3
Autor:
Theo Thepen, Stefan Barth, Rainer Fischer, Michael Huhn, Radoslav Mladenov, Eric Aslanian, Dmitrij Hristodorov, Sonja Schiffer
Publikováno v:
Antibodies, Vol 2, Iss 1, Pp 9-18 (2013)
Human cytolytic fusion proteins (hCFPs) are comprised of a specific cell-surface-binding moiety and an effector molecule of human origin. In contrast to common immunotoxins, including bacterial or plant toxins, they are considered not to be immunogen
Externí odkaz:
https://doaj.org/article/c4fc28ca06f54d36aa55e814992f431c
Publikováno v:
Toxins, Vol 4, Iss 9, Pp 676-694 (2012)
Diseases caused by chronic inflammation (e.g., arthritis, multiple sclerosis and diabetic ulcers) are multicausal, thus making treatment difficult and inefficient. Due to the age-associated nature of most of these disorders and the demographic transi
Externí odkaz:
https://doaj.org/article/7fa1e3df119f408784b35252be829c6d
Autor:
Olusiji A. Akinrinmade, Shivan Chetty, Adebukola K. Daramola, Mukit-ul Islam, Theo Thepen, Stefan Barth
Publikováno v:
Biomedicines, Vol 5, Iss 3, p 56 (2017)
To date, no curative therapy is available for the treatment of most chronic inflammatory diseases such as atopic dermatitis, rheumatoid arthritis, or autoimmune disorders. Current treatments require a lifetime supply for patients to alleviate clinica
Externí odkaz:
https://doaj.org/article/2b062270a5b34f8fadcb49a87a9c3a1e
Autor:
Stefan Barth, Theo Thepen, Rainer Fischer, Wijnand Helfrich, Michael Huhn, Anh-Tuan Pham, Stefano Di Fiore, Lea Hein, Nina Berges, Katharina Arens, Judith Niesen, Radoslav Mladenov, Manal Amoury, Dmitrij Hristodorov
In normal epithelia, the epithelial cell adhesion molecule (EpCAM) expression is relatively low and only present at the basolateral cell surface. In contrast, EpCAM is aberrantly overexpressed in various human carcinomas. Therefore, EpCAM is consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea71e0953fc9d55f5c4cbe58b11d9e2b
https://doi.org/10.1158/1535-7163.c.6536832.v1
https://doi.org/10.1158/1535-7163.c.6536832.v1
Autor:
Stefan Barth, Theo Thepen, Rainer Fischer, Wijnand Helfrich, Michael Huhn, Anh-Tuan Pham, Stefano Di Fiore, Lea Hein, Nina Berges, Katharina Arens, Judith Niesen, Radoslav Mladenov, Manal Amoury, Dmitrij Hristodorov
Supplementary Figure 1. Cell-binding activity of anti-EpCAM(scFv)-MAP to further target cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce37cdf8635b8b1ddc6d600c2efea6d
https://doi.org/10.1158/1535-7163.22501572.v1
https://doi.org/10.1158/1535-7163.22501572.v1
Publikováno v:
Immunology & Cell Biology. 94:470-478
Classical immunotoxins compromise a binding component (for example, a ligand, antibody or fragment thereof) and a cytotoxic component, usually derived from bacteria or plants (for example, Pseudomonas exotoxin A or ricin). Despite successful testing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83369b84990e3100fd9f5054620307cb
https://doi.org/10.1038/icb.2016.4
https://doi.org/10.1038/icb.2016.4
Autor:
Theo Thepen, Stefan Barth
Publikováno v:
Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins ISBN: 9783319468754
Over the last couple of decades, a demographic transition towards an aging population has occurred. This has been accompanied by an increase in chronic inflammatory disorders like atopic dermatitis, rheumatoid arthritis, and diabetic ulcers, as many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf7afc714eb9f2b16b4418c8d3880167
https://doi.org/10.1007/978-3-319-46877-8_7
https://doi.org/10.1007/978-3-319-46877-8_7
Autor:
Stefan Barth, Hannes Brehm, Dmitrij Hristodorov, Theo Thepen, Radoslav Mladenov, Rainer Fischer
Publikováno v:
mAbs. 6:1283-1289
Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that plays a critical role in many inflammatory diseases. Soluble TNF can be neutralized by monoclonal antibodies (mAbs), and this is a widely-used therapeutic approach. However, some patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3787deff311a3ea3bbf54c86f4c3a69
https://doi.org/10.4161/mabs.32182
https://doi.org/10.4161/mabs.32182
Autor:
Rainer Fischer, Manal Amoury, Wijnand Helfrich, Theo Thepen, Michael Huhn, Judith Niesen, Stefan Barth, Dmitrij Hristodorov, Anh-Tuan Pham, Nina Berges, Katharina Arens, Stefano Di Fiore, Radoslav Mladenov, Lea Hein
Publikováno v:
Molecular cancer therapeutics, 13(9), 2194-2202. AMER ASSOC CANCER RESEARCH
In normal epithelia, the epithelial cell adhesion molecule (EpCAM) expression is relatively low and only present at the basolateral cell surface. In contrast, EpCAM is aberrantly overexpressed in various human carcinomas. Therefore, EpCAM is consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d51abf0315313a1e971758721fdcd77
https://research.rug.nl/en/publications/159cefec-7708-4fe1-98ed-4167a96eb181
https://research.rug.nl/en/publications/159cefec-7708-4fe1-98ed-4167a96eb181