Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Theo Rein"'
Autor:
Dietmar Spengler, Theo Rein
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/b47407773400407ea583495dc9991a8d
Publikováno v:
Stem Cells International, Vol 2022 (2022)
Motor neurons (MNs) derived from human-induced pluripotent stem cells (hiPSC) hold great potential for the treatment of various motor neurodegenerative diseases as transplantations with a low-risk of rejection are made possible. There are many hiPSC
Externí odkaz:
https://doaj.org/article/cfaf7c1a59ee443b93f56272c5afdb00
Autor:
Nils C. Gassen, Daniela Niemeyer, Doreen Muth, Victor M. Corman, Silvia Martinelli, Alwine Gassen, Kathrin Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, Anthony S. Zannas, Alexander Herrmann, Florian Holsboer, Ruth Brack-Werner, Michael Boshart, Bertram Müller-Myhsok, Christian Drosten, Marcel A. Müller, Theo Rein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Here, Gassen et al. show that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replica
Externí odkaz:
https://doaj.org/article/173953915c6a47688637a8c938baf515
Autor:
Leonie Herrmann, Tim Ebert, Helena Rosen, Bozidar Novak, Alexandra Philipsen, Chadi Touma, Monika Schreckenbach, Nils C. Gassen, Theo Rein, Ulrike Schmidt
Publikováno v:
Neurobiology of Stress, Vol 15, Iss , Pp 100401- (2021)
As the cerebellar molecular stress response is understudied, we assessed protein expression levels of hypothalamic-pituitary-adrenal (HPA) axis regulators and neurostructural markers in the cerebellum of a male PTSD mouse model and of unstressed vs.
Externí odkaz:
https://doaj.org/article/17791f55f2c54368988cadadeaf707b2
Autor:
Georgia Balsevich, Alexander S. Häusl, Carola W. Meyer, Stoyo Karamihalev, Xixi Feng, Max L. Pöhlmann, Carine Dournes, Andres Uribe-Marino, Sara Santarelli, Christiana Labermaier, Kathrin Hafner, Tianqi Mao, Michaela Breitsamer, Marily Theodoropoulou, Christian Namendorf, Manfred Uhr, Marcelo Paez-Pereda, Gerhard Winter, Felix Hausch, Alon Chen, Matthias H. Tschöp, Theo Rein, Nils C. Gassen, Mathias V. Schmidt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Stress is recognized as risk factor for the development of type 2 diabetes. Here Balsevich et al. show that the stress responsive co-chaperone FKBP5 regulates glucose metabolism in mice by modulating AS160 phosphorylation, glucose transporter express
Externí odkaz:
https://doaj.org/article/76e5768290f04b6780cef2511b5d398b
Autor:
Nils C. Gassen, Theo Rein
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
Autophagy has been recognized as evolutionary conserved intracellular pathway that ensures energy, organelle, and protein homeostasis through lysosomal degradation of damaged macromolecules and organelles. It is activated under various stress situati
Externí odkaz:
https://doaj.org/article/5d599ba5697343b5b32612412324cae8
Autor:
Theo Rein
Publikováno v:
Cells, Vol 8, Iss 1, p 44 (2019)
Autophagy has received increased attention as a conserved process governing cellular energy and protein homeostasis that is thus relevant in a range of physiological and pathophysiological conditions. Recently, autophagy has also been linked to depre
Externí odkaz:
https://doaj.org/article/f46bb0073a0b4bd9808382c17488310f
Autor:
Thomas Kirmeier, Ranganath Gopalakrishnan, Vanessa Gormanns, Anna M Werner, Serena Cuboni, Georg C Rudolf, Georg Höfner, Klaus T Wanner, Stephan A Sieber, Ulrike Schmidt, Florian Holsboer, Theo Rein, Felix Hausch
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148608 (2016)
The aim of this study was to design, synthesize and validate a multifunctional antidepressant probe that is modified at two distinct positions. The purpose of these modifications was to allow covalent linkage of the probe to interaction partners, and
Externí odkaz:
https://doaj.org/article/c7800bb20b1a4b45897b23cc0a2bd9b8
Autor:
Nils C Gassen, Jakob Hartmann, Jürgen Zschocke, Jens Stepan, Kathrin Hafner, Andreas Zellner, Thomas Kirmeier, Lorenz Kollmannsberger, Klaus V Wagner, Nina Dedic, Georgia Balsevich, Jan M Deussing, Stefan Kloiber, Susanne Lucae, Florian Holsboer, Matthias Eder, Manfred Uhr, Marcus Ising, Mathias V Schmidt, Theo Rein
Publikováno v:
PLoS Medicine, Vol 11, Iss 11, p e1001755 (2014)
FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of the glucocorticoid receptor, and consequently of stress physiology. Clinical studies suggest a genetic link between FKBP51 and antidepressant response in mood disorders; howe
Externí odkaz:
https://doaj.org/article/579581adbb6d42f9834bda6ac2728094
Autor:
Regina T Knapp, Michael J H Wong, Lorenz K Kollmannsberger, Nils C Gassen, Anja Kretzschmar, Jürgen Zschocke, Kathrin Hafner, Jason C Young, Theo Rein
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85415 (2014)
Hsp70 binding protein 1 (HspBP1) and Bcl2-associated athanogene 1 (BAG-1), the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70) chaperones, catalyze the release of ADP from Hsp70 while inducing
Externí odkaz:
https://doaj.org/article/f646c17951414cd8b067fdfcea33ed82