Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Theo L. Peeters"'
Publikováno v:
Fundamental & Clinical Pharmacology. 22:537-547
The present study, aimed to clarify whether the gastrointestinal adverse effects following administration of the bronchodilator theophylline are owing to the action of the drug itself or its metabolites, investigates the pharmacodymanic effects of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd2a6f7220dd8cb8c5ebd74e77574e0
https://doi.org/10.1111/j.1472-8206.2008.00619.x
https://doi.org/10.1111/j.1472-8206.2008.00619.x
Autor:
Gaston Vantrappen, Inge Depoortere, Jos Hoogmartens, T Cachet, Gert Matthijs, Theo L. Peeters
Publikováno v:
Neurogastroenterology & Motility. 1:150-159
ERYTHROMYCIN A appears to be a motilin agonist, although motilin (a peptide) and erythromycin A (a 14-member macrolide antibiotic carrying two sugar substituents) are structurally totally unrelated. To obtain information concerning the structural req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97af0bc7c3fb26c46c84107d31c9f05f
https://doi.org/10.1111/j.1365-2982.1989.tb00154.x
https://doi.org/10.1111/j.1365-2982.1989.tb00154.x
Publikováno v:
British Journal of Pharmacology. 153:1550-1557
Background and purpose: The finding that obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's stimulatory effect on food intake and gastric emptying has been questioned. The effect of obestatin has been mostly investigated in fasted ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f5d7455e9d35c7deb080d6ca56a19af
https://doi.org/10.1038/sj.bjp.0707683
https://doi.org/10.1038/sj.bjp.0707683
Autor:
Kenshi Kamei, Mitsu Onoma, Hiroyasu Muramatsu, Osamu Kuromaru, Shoshin Yoshida, Theo L. Peeters, Hirokazu Sudo, Osamu Cynshi, Kenji Yogo, Hisanori Takanashi, Ken-ichi Ozaki
Publikováno v:
European Journal of Pharmacology. 581:296-305
The pharmacological properties of MA-2029, a novel motilin receptor antagonist, were investigated. In vitro , MA-2029 (1 to 30 nM) competitively inhibited motilin-induced contractions in isolated rabbit duodenal longitudinal muscle strips, with a pA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7095b4aaab7f77f348a3a149ab1de62a
https://doi.org/10.1016/j.ejphar.2007.11.049
https://doi.org/10.1016/j.ejphar.2007.11.049
Publikováno v:
Biochemical Pharmacology. 75:1115-1128
Backgrounds & aims The motilin receptor (MTLR) is an important therapeutic target for treatment of hypomotility disorders. The negative outcome in clinical trials with the motilin agonist, ABT-229, indicated that desensitization may limit the therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b84455476a7f2a3f251004778011925
https://doi.org/10.1016/j.bcp.2007.11.004
https://doi.org/10.1016/j.bcp.2007.11.004
Autor:
Luc Hoskens, Guy Daneels, Dieder Moechars, Luc Ver Donck, Ilse Goris, Betty De Smet, Bernard Coulie, Inge Depoortere, Stefan Kass, Benoit Moreaux, Theo L. Peeters
Publikováno v:
Gastroenterology. 131:1131-1141
Background & Aims: The G-protein–coupled receptor GPR39 is a member of a family that includes the receptors for ghrelin and motilin. Recently the peptide obestatin was identified as a natural ligand for GPR39. The objective of this study was to gai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416fe609b5cef3a854794c1452d2b503
https://doi.org/10.1053/j.gastro.2006.07.009
https://doi.org/10.1053/j.gastro.2006.07.009
Autor:
Theo L. Peeters
Publikováno v:
Neurogastroenterology and Motility. 18:1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad23871b0d6dc8d448de4d7a3cebff9
https://doi.org/10.1111/j.1365-2982.2005.00749.x
https://doi.org/10.1111/j.1365-2982.2005.00749.x
Autor:
Theo L. Peeters
Publikováno v:
Current opinion in endocrinology, diabetes, and obesity. 22(1)
Purpose of review To summarize the recent findings. Recent findings Studies of changes in the plasma levels confirm the earlier concepts, but offer little proof of causal effect. It is increasingly realized that peptides produced in the gut have a pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a0a74bc36005fdea746a1fc9524182
https://pubmed.ncbi.nlm.nih.gov/25517024
https://pubmed.ncbi.nlm.nih.gov/25517024
Autor:
Patrick Robberecht, Luo Xu, Pascale Vertongen, Inge Depoortere, Theo L. Peeters, Magali Waelbroeck
Publikováno v:
Biochemical Pharmacology. 70:879-887
The motilin receptor (MTLR) represents a clinically useful pharmacological target, as agonists binding to the MTLR have gastroprokinetic properties. In order to compare the molecular basis for interaction of the MTLR with motilin and with the non-pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69fd6ec7084b6f26dc5dd68c0e6b361f
https://doi.org/10.1016/j.bcp.2005.06.022
https://doi.org/10.1016/j.bcp.2005.06.022
Autor:
Joris G. De Man, Inge Depoortere, Theo L. Peeters, Theo Thijs, Paul A. Pelckmans, Benedicte Y. De Winter
Publikováno v:
European journal of pharmacology
Ghrelin and motilin form a new family of structurally related peptides. We compared the gastroprokinetic effects of ghrelin, the ghrelin receptor agonist, growth hormone releasing peptide 6 (GHRP-6), and motilin in rats in vivo and in vitro. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71c83607ce33f72cc09ecf0c9a28b26
https://doi.org/10.1016/j.ejphar.2005.04.008
https://doi.org/10.1016/j.ejphar.2005.04.008