Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Theo H. van Dijk"'
Autor:
Catriona Ling, Christian J. Versloot, Matilda E. Arvidsson Kvissberg, Guanlan Hu, Nathan Swain, José M. Horcas-Nieto, Emily Miraglia, Mehakpreet K. Thind, Amber Farooqui, Albert Gerding, Karen van Eunen, Mirjam H. Koster, Niels J. Kloosterhuis, Lijun Chi, YueYing ChenMi, Miriam Langelaar-Makkinje, Celine Bourdon, Jonathan Swann, Marieke Smit, Alain de Bruin, Sameh A. Youssef, Marjon Feenstra, Theo H. van Dijk, Kathrin Thedieck, Johan W. Jonker, Peter K. Kim, Barbara M. Bakker, Robert H.J. Bandsma
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104809- (2023)
Summary: Background: The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection and mortality. SM dysregulates the tryptophan-kynurenine pathway, which may impact processes s
Externí odkaz:
https://doaj.org/article/030dcd61c99342418554af2a1f59e28d
Autor:
Anna Palmiotti, Hilde D. de Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Esther Verkade, Melany K. Veentjer, Theo H. van Dijk, Vincent W. Bloks, Rick Havinga, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2495 (2023)
Bile acids (BAs) and their signaling pathways have been identified as therapeutic targets for liver and metabolic diseases. We generated Cyp2c70−/− (KO) mice that were not able to convert chenodeoxycholic acid into rodent-specific muricholic acid
Externí odkaz:
https://doaj.org/article/6f2bbd3a48534fe2b250f2e7649963fb
Autor:
Shiqi Zhong, Raphael Chèvre, David Castaño Mayan, Maria Corlianò, Blake J. Cochran, Kai Ping Sem, Theo H. van Dijk, Jianhe Peng, Liang Juin Tan, Siddesh V. Hartimath, Boominathan Ramasamy, Peter Cheng, Albert K. Groen, Folkert Kuipers, Julian L. Goggi, Chester Drum, Rob M. van Dam, Ru San Tan, Kerry-Anne Rye, Michael R. Hayden, Ching-Yu Cheng, Shaji Chacko, Jason Flannick, Xueling Sim, Hong Chang Tan, Roshni R. Singaraja
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
BACKGROUND Cytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated bile acids (BAs) that are associated with insulin resistance in humans.METHODS To determine whether reduced CYP8B1 activity improves insulin sensitivity, we
Externí odkaz:
https://doaj.org/article/d03f46bd050f440897a9444be497521e
Autor:
Alessandro Rossi, Martijn G. S. Rutten, Theo H. van Dijk, Barbara M. Bakker, Dirk-Jan Reijngoud, Maaike H. Oosterveer, Terry G. J. Derks
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Hypoglycemia results from an imbalance between glucose entering the blood compartment and glucose demand, caused by a defect in the mechanisms regulating postprandial glucose homeostasis. Hypoglycemia represents one of the most common metabolic emerg
Externí odkaz:
https://doaj.org/article/aa2748dec44245458a088fa145090a7d
Autor:
Jiufang Yang, Theo H. van Dijk, Martijn Koehorst, Rick Havinga, Jan Freark de Boer, Folkert Kuipers, Tim van Zutphen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4132 (2023)
Bile acids facilitate the intestinal absorption of dietary lipids and act as signalling molecules in the maintenance of metabolic homeostasis. Farnesoid X receptor (FXR) is a bile acid-responsive nuclear receptor involved in bile acid metabolism, as
Externí odkaz:
https://doaj.org/article/8fe97708e815448d809de3a14f82fda1
Autor:
Yared Paalvast, Enchen Zhou, Yvonne J. W. Rozendaal, Yanan Wang, Albert Gerding, Theo H. van Dijk, Jan Freark de Boer, Patrick C. N. Rensen, Ko Willems van Dijk, Jan A. Kuivenhoven, Barbara M. Bakker, Natal A. W. van Riel, Albert K. Groen
Publikováno v:
Nutrients, Vol 14, Iss 22, p 4936 (2022)
Within the human population, considerable variability exists between individuals in their susceptibility to develop obesity and dyslipidemia. In humans, this is thought to be caused by both genetic and environmental variation. APOE*3-Leiden.CETP mice
Externí odkaz:
https://doaj.org/article/cdeba04b0756445cafd9e87ba5a1fbe2
Autor:
Tim van Zutphen, Johanna H.M. Stroeve, Jiufang Yang, Vincent W. Bloks, Angelika Jurdzinski, Han Roelofsen, Nicolette C.A. Huijkman, Theo H. van Dijk, Roel J. Vonk, Jan van Deursen, Bart Staels, Albert K. Groen, Folkert Kuipers
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1547-1561 (2019)
The bile acid-activated nuclear receptor, FXR (NR1H4), has been implicated in the control of lipid and energy metabolism, but its role in fat tissue, where it is moderately expressed, is not understood. In view of the recent development of FXR-target
Externí odkaz:
https://doaj.org/article/8840b252e57a440b90ac25aad4d7f14e
Autor:
Ivo P. van de Peppel, Anna Bertolini, Theo H. van Dijk, Albert K. Groen, Johan W. Jonker, Henkjan J. Verkade
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1562-1572 (2019)
Transintestinal cholesterol excretion (TICE) is a major route for eliminating cholesterol from the body and a potential therapeutic target for hypercholesterolemia. The underlying mechanism, however, is largely unclear, and its contribution to choles
Externí odkaz:
https://doaj.org/article/981e13cd35934e3b9f41e82dcafc4319
Autor:
Marcela Doktorova, Irene Zwarts, Tim van Zutphen, Theo H. van Dijk, Vincent W. Bloks, Liesbeth Harkema, Alain de Bruin, Michael Downes, Ronald M. Evans, Henkjan J. Verkade, Johan W. Jonker
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Peroxisome proliferator-activated receptor δ (PPARδ) is a ligand-activated transcription factor that has an important role in lipid metabolism. Activation of PPARδ stimulates fatty acid oxidation in adipose tissue and skeletal muscle and
Externí odkaz:
https://doaj.org/article/adc9aeb287f8410a912102df98040a2d
Autor:
Ruud S. Kootte, Loek P. Smits, Fleur M. van der Valk, Jean-Louis Dasseux, Constance H. Keyserling, Ronald Barbaras, John F. Paolini, Raul D. Santos, Theo H. van Dijk, Geesje M. Dallinga-van Thie, Aart J. Nederveen, WillemJ.M. Mulder, G.Kees Hovingh, JohnJ.P. Kastelein, Albert K. Groen, ErikS. Stroes
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 703-712 (2015)
Reverse cholesterol transport (RCT) contributes to the anti-atherogenic effects of HDL. Patients with the orphan disease, familial hypoalphalipoproteinemia (FHA), are characterized by decreased tissue cholesterol removal and an increased atherogenic
Externí odkaz:
https://doaj.org/article/0198d50b673d41dea68fe895d4ff2269