Reduced startle reactivity and plasticity in transgenic mice overexpressing corticotropin-releasing hormone

Autor: Lucianne Groenink, Berend Olivier, Marlies Iutje Schipholt, Theo H. Hijzen, Anneloes Dirks, Jan van der Gugten, Mark A. Geyer

Publikováno v: Biological Psychiatry. 51:583-590

Background: Corticotropin-releasing hormone (CRH) hyperactivity in transgenic mice overexpressing CRH in the brain (CRH-OE 2122 ) appears to be associated with chronic stress-like alterations, including increased CRH content in the hypothalamus, chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cc329898363d93352c7fa91ee0d75d
https://doi.org/10.1016/s0006-3223(01)01323-3

Footshock-induced sensitization of the acoustic startle response in two strains of mice

Autor: Lucianne Groenink, Anneloes Dirks, Jan van der Gugten, Berend Olivier, Theo H. Hijzen, Reinoud de Jongh

Publikováno v: Behavioural Brain Research. 123:17-21

It has been shown before that unconditioned footshocks can augment the acoustic startle response in rats. In the present study, male mice of two strains, C57Bl/6N and BALB/c, were compared with regard to footshock-induced sensitization of the acousti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed43fe69a53e448752790070f9c625d
https://doi.org/10.1016/s0166-4328(01)00193-0

5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response

Autor: Tommy Pattij, Tatjana T Westphal, Lucianne Groenink, J. Adriaan Bouwknecht, Anneloes Dirks, Jan van der Gugten, Mark A. Geyer, Ronald S. Oosting, Berend Olivier, René Hen, Theo H. Hijzen

Publikováno v: Dirks, A, Pattij, T, Adriaan Bouwknecht, J, Westphal, T T, Hijzen, T H, Groenink, L, Van der Gugten, J, Oosting, R S, Hen, R, Geyer, M A & Olivier, B 2001, ' 5-HT 1B receptor knockout, but not 5-HT 1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response ', Behavioural Brain Research, vol. 118, no. 2, pp. 169-178 . https://doi.org/10.1016/S0166-4328(00)00326-0
Behavioural Brain Research, 118(2), 169-178. Elsevier

To investigate whether the hyperreactivity to mild environmental and novel stimuli in 5-HT1B receptor knockout (1BKO) mice, as suggested by measures of exploratory, aggressive, and impulsive behaviors, can be extended to phasic stimuli, 1BKO and wild

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255ff95a2fa07196aa67ad10d89c8d44
https://doi.org/10.1016/s0166-4328(00)00326-0

Infusion of flesinoxan into the amygdala blocks the fear-potentiated startle

Autor: Lucianne Groenink, Anneloes Dirks, Rosemarie J. E. Joordens, Theo H. Hijzen, Berend Olivier

Publikováno v: NeuroReport. 11:2285-2288

In a previous study it was demonstrated that flesinoxan, a selective serotonin (5-HT)1A receptor agonist, had anxiolytic properties in the fear-potentiated startle paradigm. The present study investigated the putative site of action of flesinoxan in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7712f5d3af4f41fe1b86a77fe09672e7
https://doi.org/10.1097/00001756-200007140-00043

Stimulus Properties of the Selective 5-HT Reuptake Inhibitor Fluvoxamine in Conditioned Taste Aversion Procedures

Autor: J.A. Bouwknecht, Arnoldus H.J. Herremans, Theo H. Hijzen, J. van der Gugten, Jan Gommans, Berend Olivier, T. Patty

Publikováno v: Pharmacology Biochemistry and Behavior. 64:213-220

Previous attempts to train pigeons and rats to discriminate between the antidepressant fluvoxamine and its vehicle as assessed in a drug discrimination paradigm have been without success. The present experiments were, therefore, designed to assess in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ad4a45fcc195221da162c83b6cc404
https://doi.org/10.1016/s0091-3057(99)00082-9