Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Themistocles, Dassopoulos"'
Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
Autor:
Kibrom M. Alula, Yaritza Delgado-Deida, Rosemary Callahan, Andreas Till, Lucia Underwood, Winston E. Thompson, Rhonda F. Souza, Themistocles Dassopoulos, Joseph Onyiah, K. Venuprasad, Arianne L. Theiss
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Autophagy of damaged mitochondria, called mitophagy, is an important organelle quality control process involved in the pathogenesis of inflammation, cancer, aging, and age-associated diseases. Many of these disorders are associated with alte
Externí odkaz:
https://doaj.org/article/409c2db6f86d4000bd758ce74a53ab92
Autor:
Kibrom M. Alula, Dakota N. Jackson, Andrew D. Smith, Daniel S. Kim, Kevin Turner, Elizabeth Odstrcil, Benny A. Kaipparettu, Themistocles Dassopoulos, K. Venuprasad, Linda A. Feagins, Arianne L. Theiss
Publikováno v:
Cells, Vol 10, Iss 6, p 1349 (2021)
Paneth cell defects in Crohn’s disease (CD) patients (called the Type I phenotype) are associated with worse clinical outcomes. Recent studies have implicated mitochondrial dysfunction in Paneth cells as a mediator of ileitis in mice. We hypothesiz
Externí odkaz:
https://doaj.org/article/9a244ebc2520425894a647d83e021d73
Publikováno v:
Current Medical Research and Opinion. 38:1093-1101
This real-world study evaluated biologic treatment patterns in patients with moderate-to-severe ulcerative colitis (UC).IQVIA PharMetrics, IBM MarketScan, and Optum Clinformatics were pooled to identify UC patients with ≥1 claim for UC and ≥1 cla
Autor:
Andres Yarur, Freddy Caldera, Sirimon O'Charoen, Joshua R. Korzenik, Cecile Norris, Matthew Bohm, Monika Fischer, Sara Sweeney, Alandra Weaver, Uni Wong, Sushila Dalal, Themistocles Dassopoulos, Katerina Wells, David Hudesman, Lilani P. Perera, Shrinivas Bishu, Caren Heller, Richard H. Duerr, Tara Fehlmann, Deepak Parakkal, Raymond K. Cross, James D. Lewis, Manreet Kaur, Matthew A. Ciorba, Sumona Saha, Elizabeth A. Scoville, Laura E. Raffals, Joel Pekow, Scott B. Snapper, Angela Dobes, Meenakshi Bewtra
Publikováno v:
Inflamm Bowel Dis
Background Clinical and molecular subcategories of inflammatory bowel disease (IBD) are needed to discover mechanisms of disease and predictors of response and disease relapse. We aimed to develop a study of a prospective adult research cohort with I
Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
Autor:
Kibrom M, Alula, Yaritza, Delgado-Deida, Rosemary, Callahan, Andreas, Till, Lucia, Underwood, Winston E, Thompson, Rhonda F, Souza, Themistocles, Dassopoulos, Joseph, Onyiah, K, Venuprasad, Arianne L, Theiss
Publikováno v:
Scientific reports. 13(1)
Autophagy of damaged mitochondria, called mitophagy, is an important organelle quality control process involved in the pathogenesis of inflammation, cancer, aging, and age-associated diseases. Many of these disorders are associated with altered expre
Publikováno v:
World Journal of Gastroenterology
Background Primary sclerosing cholangitis (PSC) associated inflammatory bowel disease (IBD) is a unique form of IBD (PSC-IBD) with distinct clinical and histologic features from ulcerative colitis (UC) and Crohn disease (CD). In patients with PSC and
Autor:
Jason C. Mills, Linda A. Feagins, Rhonda F. Souza, Arianne L. Theiss, LuAnn Thompson-Snipes, William L. Neumann, Marina Panopoulos, K. Venuprasad, Richard S. Blumberg, Kevin Turner, Themistocles Dassopoulos, Winston E. Thompson, Brandi L. Cantarel, Dakota N Jackson
Publikováno v:
Gut. 69:1928-1938
ObjectiveAlthough perturbations in mitochondrial function and structure have been described in the intestinal epithelium of Crohn’s disease and ulcerative colitis patients, the role of epithelial mitochondrial stress in the pathophysiology of infla
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144900 (2015)
In patients with postoperative recurrence of Crohn's disease endoscopic and clinical remission can be maintained for up to 1 year with low infliximab doses (3 mg/Kg). However, in theory low-dose infliximab treated patients could develop subtherapeuti
Externí odkaz:
https://doaj.org/article/70c10dfbb7af41d2986c4f8925420315
Autor:
Tianyi Zhang, Bowen Song, Wei Zhu, Xiao Xu, Qing Qing Gong, Christopher Morando, Themistocles Dassopoulos, Rodney D Newberry, Steven R Hunt, Ellen Li
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37139 (2012)
Previous genome-wide expression studies have highlighted distinct gene expression patterns in inflammatory bowel disease (IBD) compared to control samples, but the interpretation of these studies has been limited by sample heterogeneity with respect
Externí odkaz:
https://doaj.org/article/4bb3a86183af4001ab24f59dd3e1e60c
Autor:
Tianyi Zhang, Robert A DeSimone, Xiangmin Jiao, F James Rohlf, Wei Zhu, Qing Qing Gong, Steven R Hunt, Themistocles Dassopoulos, Rodney D Newberry, Erica Sodergren, George Weinstock, Charles E Robertson, Daniel N Frank, Ellen Li
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e30044 (2012)
The aim of this study was to integrate human clinical, genotype, mRNA microarray and 16 S rRNA sequence data collected on 84 subjects with ileal Crohn's disease, ulcerative colitis or control patients without inflammatory bowel diseases in order to i
Externí odkaz:
https://doaj.org/article/0efd7c92ea2a47e499734c4a1bcadb11