Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Themed Section - Paediatric Prescribing"'
Publikováno v:
British Journal of Clinical Pharmacology
Antibiotics are a critically important part of paediatric medical care in low- and middle-income countries (LMICs), where infectious diseases are the leading cause of child mortality. The World Health Organization estimates that >50% of all medicines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d7e9a1bafeeba67c18fc8f427738f4
https://doi.org/10.1111/bcp.12320
https://doi.org/10.1111/bcp.12320
The translation of pharmacogenomics into clinical practice is a key approach for practising individualized medicine, which aims to maximize drug efficacy and minimize drug toxicity. Since the completion of both the Human Genome Project and the Intern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::64890587785f06f4d03f5f52c6514584
https://europepmc.org/articles/PMC4345952/
https://europepmc.org/articles/PMC4345952/
Autor:
Batchelor, Hannah K, Marriott, John F
Paediatric formulation design is complex as there is a need to understand the developmental physiological changes that occur during childhood and their impact on the absorption of drugs. Paediatric dose adjustments are usually based on achieving phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd0ed162808d3ad181a22381f20e2f68
https://europepmc.org/articles/PMC4345951/
https://europepmc.org/articles/PMC4345951/
A number of anatomical and physiological factors determine the pharmacokinetic profile of a drug. Differences in physiology in paediatric populations compared with adults can influence the concentration of drug within the plasma or tissue. Healthcare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4702bee880449441f3591c3dd5be54fa
https://europepmc.org/articles/PMC4345950/
https://europepmc.org/articles/PMC4345950/
Autor:
Lenney, Warren
The British National Formulary has been in existence for over 30 years. The prescribing of medicines for children has been less well organized. Many medicines used in children have never been tested in the appropriate age groups and have been prescri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba9c7a06c72f800f3782cf49f3ad09ab
https://europepmc.org/articles/PMC4345954/
https://europepmc.org/articles/PMC4345954/
Autor:
Phuong Thu Vu, Hoang, Jérôme, Ambroise, Anne-France, Dekairelle, Jean-François, Durant, Valentina, Butoescu, Vu Luan Dang, Chi, Nghia, Huynh, Tan Binh, Nguyen, Annie, Robert, Christiane, Vermylen, Jean-Luc, Gala
Publikováno v:
British journal of clinical pharmacology. 79(3)
Acute lymphoblastic leukemia (ALL) is the most common of all paediatric cancers. Aside from predisposing to ALL, polymorphisms could also be associated with poor outcome. Indeed, genetic variations involved in drug metabolism could, at least partiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad6f8af977040c828e07c5f5f306b0e9
https://pubmed.ncbi.nlm.nih.gov/25099492
https://pubmed.ncbi.nlm.nih.gov/25099492
Publikováno v:
British journal of clinical pharmacology. 79(3)
Safety and efficacy data on many medicines used in children are surprisingly scarce. As a result children are sometimes given ineffective medicines or medicines with unknown harmful side effects. Better and more relevant clinical trials in children a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93e30db519c0ff47f459bcb515d5026b
https://pubmed.ncbi.nlm.nih.gov/24325152
https://pubmed.ncbi.nlm.nih.gov/24325152
Autor:
Mark A, Turner
Publikováno v:
British journal of clinical pharmacology. 79(3)
In the past, there has been a perception that ethical and practical problems limit the opportunities for research in neonates. This perception is no longer appropriate. It is now clear that research about the medicines used in neonates is an ethical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a48861c8ac4c25e2cbcf612eeb1a5986
https://pubmed.ncbi.nlm.nih.gov/25041601
https://pubmed.ncbi.nlm.nih.gov/25041601
Publikováno v:
British journal of clinical pharmacology. 79(3)
The development of biological agents with specific immunological targets has revolutionized the treatment of a wide variety of paediatric diseases where traditional immunosuppressive agents have been partly ineffective or intolerable. The increasing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1eee7cbbfbd246a07ca1d709aecc617
https://pubmed.ncbi.nlm.nih.gov/24750505
https://pubmed.ncbi.nlm.nih.gov/24750505