Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Thelma, Angeles"'
Autor:
Babu G, Sundar, Thomas R, Bailey, Derek D, Dunn, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Huang, Zeqi, Joanne R, Mathiasen, Amy, Dicamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Rebecca, Brown, Jie, Qian, Thelma, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Deborah, Galinis, Emir, Duzic, Herve, Schaffhauser, Gerard C, Rosse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 8(1)
Angiogenesis plays a pivotal role in tumor growth and represents a key target for chemopreventive intervention. On the basis of the structural features and lack of target organ specificity of the synthetic dithiolethione oltipraz, inhibition of angio
Autor:
Thelma Angeles, Bruce Ruggeri, Martin Carroll, Cynthia Serdikoff, Elizabeth O. Hexner, Candy Robinson, Cezary Swider, Mahfuza Jan, Stephen G. Emerson, Pawel Dobrzanski, Shi Yang
Publikováno v:
Blood. 108:3594-3594
Small molecule tyrosine kinase inhibitors have had dramatic clinical efficacy in chronic myelogenous leukemia. The identification of a specific activating mutation (V617F) in the gene encoding Janus Kinase 2 (JAK2) in a large proportion of patients w