Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.

Autor: Feldman JL; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53715., Dittenhafer-Reed KE; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53715., Kudo N; Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, Hirosawa 2-1, Wako, Saitama 351-0198, Japan., Thelen JN; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin 53715., Ito A; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Hirosawa 2-1, Wako, Saitama 351-0198, Japan., Yoshida M; Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, Hirosawa 2-1, Wako, Saitama 351-0198, Japan.; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Hirosawa 2-1, Wako, Saitama 351-0198, Japan.; JST, CREST Research Project, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan., Denu JM; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53715.; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin 53715.

Publikováno v: Biochemistry [Biochemistry] 2015 May 19; Vol. 54 (19), pp. 3037-3050. Date of Electronic Publication: 2015 May 04.