Výsledky vyhledávání - "Thelen, Maximilian Paul"

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Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons.

Autor: Thelen, Maximilian Paul^1,2 (AUTHOR), Wirth, Brunhilde^1,2,3 (AUTHOR), Kye, Min Jeong^1,2 (AUTHOR) min.kye@uk-koeln.de

Publikováno v: Acta Neuropathologica Communications. 12/22/2020, Vol. 8 Issue 1, p1-19. 19p.

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Defective Mitochondria Contribute to Impaired Translation in Spinal Muscular Atrophy

Autor: Thelen, Maximilian Paul

Spinal muscular atrophy (SMA) is a devastating, autosomal-recessive neurodegenerative disease. It is characterized by the loss of alpha motor neurons (MNs) located in the ventral horn of the spinal cord. Degeneration of lower MNs leads to proximal mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______199::fc03f353490d0ac457ca89926de1eb61
https://kups.ub.uni-koeln.de/46874/

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Additional file 1 of Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons

Autor: Thelen, Maximilian Paul, Wirth, Brunhilde, Kye, Min Jeong

Additional file 1: Supplementary Table S1. Primer sequences. S2. Antibodies and conditions for Western blot (WB) and immunofluorescence (IF). S3. Fluorescence dyes. S4. Drugs and supplements for in vitro assays.

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Additional file 3 of Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons

Autor: Thelen, Maximilian Paul, Wirth, Brunhilde, Kye, Min Jeong

Additional file 3: Supplementary Figure S1. Complex I deficiency leads to dysfunctional and fragmented mitochondria. S2. Mitochondrial complex I is impaired in SMA MNs. S3. Optimization of SUnSET assay. S4. Reduction of ROS improves protein synthesis

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