Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Thekla J. Hemstedt"'
Autor:
Daniela Mauceri, Ursula Weiss, Bettina Buchthal, Thekla J. Hemstedt, Christian D. Klein, Hilmar Bading
Publikováno v:
Proc Natl Acad Sci U S A
In the adult brain, vascular endothelial growth factor D (VEGFD) is required for structural integrity of dendrites and cognitive abilities. Alterations of dendritic architectures are hallmarks of many neurologic disorders, including stroke-induced da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1232a6f60a1a3c2e5fd22f11cbe0603
https://europepmc.org/articles/PMC7165430/
https://europepmc.org/articles/PMC7165430/
Autor:
Alberto J. López, Osasumwen V. Aimiuwu, K. Matthew Lattal, Joseph Han, Janine L. Kwapis, Kasuni K. Bodinayake, Marcelo A. Wood, Earnest S. Kim, Thekla J. Hemstedt, Amni Al-Kachak, André O. White, Nicole C. Oparaugo, Enikö A. Kramár, Yasaman Alaghband
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 38, iss 44
Epigenetic mechanisms result in persistent changes at the cellular level that can lead to long-lasting behavioral adaptations. Nucleosome remodeling is a major epigenetic mechanism that has not been well explored with regards to drug-seeking behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2047e67dfb07ef05b634ab2083ca2c33
https://doi.org/10.1523/jneurosci.2911-17.2018
https://doi.org/10.1523/jneurosci.2911-17.2018
Autor:
Weisheng Wang, Christophe Magnan, Soraya Azzawi, Rebecca J. Post, Marcelo A. Wood, Robbert Havekes, Joyce Tong, Richard Dang, Alberto J. López, Pierre Baldi, Brian H. Trieu, Ted Abel, Gary Lynch, Thekla J. Hemstedt, Ruth M. Barrett, Dina P. Matheos, Keith Sakata, Ashley Tran, Annie Vogel Ciernia, Enikö A. Kramár
Publikováno v:
Learning & memory (Cold Spring Harbor, N.Y.), vol 24, iss 5
Learning & Memory, 24(5), 199-209. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Learning & Memory, 24(5), 199-209. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Recent human exome-sequencing studies have implicated polymorphic Brg1-associated factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several intellectual disabilities and cognitive disorders, including autism. However, it re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef896c4b29aae8a7427c87e19d0be282
https://hdl.handle.net/11370/ebfe9919-d0f8-488f-b53d-739d5c70e7b3
https://hdl.handle.net/11370/ebfe9919-d0f8-488f-b53d-739d5c70e7b3
Autor:
Thekla J. Hemstedt, Alberto J. López, Rianne R. Campbell, Janine L. Kwapis, Yousheng Jia, Om Chitnis, Marcelo A. Wood, Dina P. Matheos, Vanessa M. Scarfone, Philip H. Hwang, André O. White, Gary Lynch
Publikováno v:
Neuropharmacology
Propensity to relapse following long periods of abstinence is a key feature of substance use disorder. Drugs of abuse, such as cocaine, cause long-term changes in the neural circuitry regulating reward, motivation, and memory processes through dysreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8838eb4345ca1a0fed41b094ea1cee34
https://escholarship.org/uc/item/2vf3j5md
https://escholarship.org/uc/item/2vf3j5md
Autor:
Thekla J. Hemstedt, Thomas Lissek, Hilmar Bading, Nazzareno Cannella, Ana M.M. Oliveira, Rainer Spanagel, Elena Buechler
Epigenetic mechanisms have gained increasing attention as regulators of synaptic plasticity and responsiveness to drugs of abuse. In particular, it has been shown that the activity of the DNA methyltransferase 3a (Dnmt3a) mediates certain long-lastin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582bd3bcae5fd4109ba6ace3b556a88d
http://hdl.handle.net/11581/439895
http://hdl.handle.net/11581/439895
Publikováno v:
Molecular Psychiatry. 21:1130-1136
The mechanisms responsible for fear memory formation and extinction are far from being understood. Uncovering the molecules and mechanisms regulating these processes is vital for identifying molecular targets for the development of novel therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4040eccd81181c8262d273752e9686c5
https://doi.org/10.1038/mp.2015.175
https://doi.org/10.1038/mp.2015.175
Publikováno v:
Neurobiology of learning and memory, vol 142, iss Pt A
Epigenetic mechanisms have the potential to give rise to lasting changes in cell function that ultimately can affect behavior persistently. This concept is especially interesting with respect to fear reconsolidation and fear memory extinction. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293b56ff7314b34d14d48701eed7ecd2
https://pubmed.ncbi.nlm.nih.gov/28119018
https://pubmed.ncbi.nlm.nih.gov/28119018
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(29)
Nuclear calcium is an important signaling end point in synaptic excitation–transcription coupling that is critical for long-term neuroadaptations. Here, we show that nuclear calcium acting via a target gene, VEGFD, is required for hippocampus-depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1d5e10e6b73b010077f93c25d8ff3a
https://pubmed.ncbi.nlm.nih.gov/28626015
https://pubmed.ncbi.nlm.nih.gov/28626015
Publikováno v:
Nature Neuroscience.
Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b27080c0f0a85ef6e4dc74a8b35971