Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Thekkumkat Thomas"'
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 39:787-794
We determined the loading efficacy of folic acid–PAMAM–G3 and folic acid–PAMAM–G4 nanoparticles with doxorubicin (Dox), tamoxifen (Tam) and tetracycline (Tet) in aqueous solution at pH 7.2. Thermod...
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 37:1000-1006
Conjugation of polymer with multiple targeting ligands has become a popular approach for targeted drug delivery (van Dongen, Dougherty, & Banaszak Holl, 2014). These polymers aid the drug solubilit...
Autor:
L. Bekale, P. Chanphai, S. Sanyakamdhorn, Daniel Agudelo, H.A. Tajmir-Riahi, Thekkumkat Thomas, Gervais Bérubé
Publikováno v:
Canadian Journal of Chemistry. 95:891-896
The binding efficacy of anticancer drugs doxorubicin and tamoxifen with polyamidoamine (PAMAM-G4) dendrimers was studied in aqueous solution at physiological pH. The results of multiple spectroscopic methods, transmission electron microscopy (TEM), a
Autor:
Ping Ar Yang, Tuomo A. Keinänen, Thresia Thomas, Hui-Chen Hsu, Shali John, Thekkumkat Thomas, Mervi T. Hyvönen
Publikováno v:
Amino Acids. 48:2293-2302
Tamoxifen is the most widely used drug to treat women with estrogen receptor α (ERα)-positive breast cancer. Endoxifen is recognized as the active metabolite of tamoxifen in humans. We studied endoxifen effects on ERα-positive MCF-7 breast cancer
Publikováno v:
Amino Acids. 48:2423-2431
Polyamines are positively charged organic cations under physiologic ionic and pH conditions and hence they interact with negatively charged macromolecules such as DNA and RNA. Although electrostatic interaction is the predominant mode of polyamine-nu
Publikováno v:
RSC Advances. 6:53690-53697
Polyamine–protein conjugates can be used as delivery tools to transport antitumor polyamine analogues. We report the conjugation of trypsin and trypsin inhibitor with biogenic polyamines spermine (spm), spermidine (spmd) and synthetic polyamines 3,
Autor:
Thresia Thomas, Thekkumkat Thomas
Publikováno v:
International journal of biological macromolecules. 109
The dawn of molecular biology and recombinant DNA technology arose from our ability to manipulate DNA, including the process of collapse of long extended DNA molecules into nanoparticles of approximately 100 nm diameter. This condensation process is
Publikováno v:
Molecules, Vol 24, Iss 20, p 3744 (2019)
Molecules
Molecules
The cellular transport process of DNA is hampered by cell membrane barriers, and hence, a delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a variety of genetic diseases. Virus-based vehicles are effective,
Publikováno v:
International journal of biological macromolecules. 92
We have reviewed the conjugation of biogenic polyamines spermine (spm), spermidine (spmd) and synthetic polyamines 3,7,11,15-tetrazaheptadecane.4HCl (BE-333) and 3,7,11,15,19-pentazahenicosane.5HCl (BE-3333) with human serum albumin (HSA), bovine ser
Autor:
H.A. Tajmir-Riahi, P. Bourassa, Ghulam M. Maharvi, Abdul H. Fauq, Thekkumkat Thomas, S. Dubeau
Publikováno v:
Biochimie. 93:1089-1101
Tamoxifen is extensively metabolized, and several metabolites have been detected in human serum. The aim of this study was to examine the interaction of human serum albumin (HSA) with tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen at