Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.

Autor: Gargaro M; Department of Medicine and Surgery, University of Perugia, Perugia, Italy; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Scalisi G; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Manni G; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Briseño CG; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Bagadia P; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Durai V; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Theisen DJ; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Kim S; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Castelli M; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Xu CA; Department of Electrical Engineering & Computer Science, Center for Computational Biology, University of California, Berkeley, CA, USA., Meyer Zu Hörste G; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Servillo G; Department of Medicine and Surgery, University of Perugia, Perugia, Italy; University research center in functional genomics (c.u.r.ge.f.), University of Perugia, Perugia, Italy., Della Fazia MA; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Mencarelli G; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Ricciuti D; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Padiglioni E; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Giacchè N; TES Pharma, Loc. Taverne, Corciano, Italy., Colliva C; TES Pharma, Loc. Taverne, Corciano, Italy., Pellicciari R; TES Pharma, Loc. Taverne, Corciano, Italy., Calvitti M; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Zelante T; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Fuchs D; Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria., Orabona C; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Boon L; Bioceros, Utrecht, the Netherlands., Bessede A; Immusmol, Bordeaux, France., Colonna M; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Puccetti P; Department of Medicine and Surgery, University of Perugia, Perugia, Italy; University research center in functional genomics (c.u.r.ge.f.), University of Perugia, Perugia, Italy., Murphy TL; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Murphy KM; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Howard Hughes Medical Institute, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. Electronic address: kmurphy@wustl.edu., Fallarino F; Department of Medicine and Surgery, University of Perugia, Perugia, Italy; University research center in functional genomics (c.u.r.ge.f.), University of Perugia, Perugia, Italy. Electronic address: francesca.fallarino@unipg.it.

Publikováno v: Immunity [Immunity] 2022 Jun 14; Vol. 55 (6), pp. 1032-1050.e14.

Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity.

Autor: Zhivaki D; Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA., Borriello F; Harvard Medical School and Division of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy., Chow OA; Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Doran B; Department of Chemistry, Institute for Medical Engineering and Sciences (IMES), Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02142, USA; Ragon Institute of MGH, Harvard, and MIT, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Fleming I; Department of Chemistry, Institute for Medical Engineering and Sciences (IMES), Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02142, USA; Ragon Institute of MGH, Harvard, and MIT, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Theisen DJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Pallis P; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Shalek AK; Department of Chemistry, Institute for Medical Engineering and Sciences (IMES), Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02142, USA; Ragon Institute of MGH, Harvard, and MIT, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Sokol CL; Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Zanoni I; Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School and Division of Immunology, Boston Children's Hospital, Boston, MA, USA., Kagan JC; Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA. Electronic address: jonathan.kagan@childrens.harvard.edu.

Publikováno v: Cell reports [Cell Rep] 2020 Nov 17; Vol. 33 (7), pp. 108381.

cDC1 prime and are licensed by CD4 ⁺ T cells to induce anti-tumour immunity.

Autor: Ferris ST; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Durai V; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Wu R; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Theisen DJ; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Ward JP; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Bern MD; Division of Rheumatology, Washington University School of Medicine, St Louis, MO, USA., Davidson JT 4th; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Department of Surgery, Washington University School of Medicine, St Louis, MO, USA., Bagadia P; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Liu T; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Briseño CG; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Li L; Department of Surgery, Washington University School of Medicine, St Louis, MO, USA., Gillanders WE; Department of Surgery, Washington University School of Medicine, St Louis, MO, USA.; The Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St Louis, MO, USA., Wu GF; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Yokoyama WM; Division of Rheumatology, Washington University School of Medicine, St Louis, MO, USA., Murphy TL; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Schreiber RD; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Murphy KM; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA. kmurphy@wustl.edu.; Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO, USA. kmurphy@wustl.edu.

Publikováno v: Nature [Nature] 2020 Aug; Vol. 584 (7822), pp. 624-629. Date of Electronic Publication: 2020 Aug 12.

WDFY4 is required for cross-presentation in response to viral and tumor antigens.

Autor: Theisen DJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Davidson JT 4th; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA., Briseño CG; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Gargaro M; Department of Experimental Medicine, University of Perugia, Perugia, Italy., Lauron EJ; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Wang Q; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Desai P; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Durai V; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Bagadia P; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Brickner JR; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Beatty WL; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Virgin HW; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Vir Biotechnology, San Francisco, CA, USA., Gillanders WE; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.; Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO 63110, USA., Mosammaparast N; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Diamond MS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA., Sibley LD; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Yokoyama W; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Schreiber RD; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA., Murphy TL; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Murphy KM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. kmurphy@wustl.edu.; Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2018 Nov 09; Vol. 362 (6415), pp. 694-699.

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Autor: Uenishi GI; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, 53715, USA.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA., Jung HS; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, 53715, USA., Kumar A; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, 53715, USA., Park MA; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, 53715, USA., Hadland BK; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, 98109, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., McLeod E; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, 53715, USA., Raymond M; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, 53715, USA.; Department of Biomedical Sciences, University of Wisconsin School of Veterinary Medicine, Madison, WI, 53706, USA., Moskvin O; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, 53715, USA., Zimmerman CE; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, 53715, USA., Theisen DJ; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, 53715, USA., Swanson S; Morgridge Institute for Research, Madison, WI, 53715, USA., J Tamplin O; Department of Pharmacology, University of Illinois, Chicago, IL, 60612, USA., Zon LI; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA, 02115, USA., Thomson JA; Morgridge Institute for Research, Madison, WI, 53715, USA.; Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53707, USA.; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, 93106, USA., Bernstein ID; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, 98109, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Slukvin II; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, 53715, USA. islukvin@wisc.edu.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA. islukvin@wisc.edu.; Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53707, USA. islukvin@wisc.edu.

Publikováno v: Nature communications [Nat Commun] 2018 May 08; Vol. 9 (1), pp. 1828. Date of Electronic Publication: 2018 May 08.