Metabolic engineering of cucurbitacins in Cucurbita pepo hairy roots

Autor: Aldo Almeida, Lemeng Dong, Theis H. Thorsen, Morten H. Raadam, Bekzod Khakimov, Natalia Carreno-Quintero, Sotirios C. Kampranis, Søren Bak

Publikováno v: Frontiers in Plant Science, Vol 13 (2022)

In this paper we show that metabolic engineering in Cucurbita pepo hairy roots can be used to both effectively increase and modify cucurbitacins. Cucurbitacins are highly-oxygenated triterpenoids originally described in the Cucurbitaceae family, but

Externí odkaz: https://doaj.org/article/e9b5e657ee2149f985cc1b2bfeb666ce

A modified EBMT risk score and the hematopoietic cell transplantation-specific comorbidity index for pre-transplant risk assessment in adult acute lymphoblastic leukemia

Autor: Theis H. Terwey, Philipp G. Hemmati, Peter Martus, Ekkehart Dietz, Lam G. Vuong, Gero Massenkeil, Bernd Dörken, Renate Arnold

Publikováno v: Haematologica, Vol 95, Iss 5 (2010)

Background Disease stage is the most important prognostic parameter in allogeneic hematopoietic cell transplantation (HCT) for acute lymphoblastic leukemia, but other factors such as donor/host histocompatibility and gender combination, recipient age

Externí odkaz: https://doaj.org/article/7576510aa35a45a6a2c60163af50ee92

System identification of thermal building models for demand response – A practical approach

Autor: Knudsen, Michael D., Hedegaard, Rasmus E., Pedersen, Theis H., Petersen, Steffen

Publikováno v: In Energy Procedia September 2017 122:937-942

Cellular and Molecular Changes in Hippocampal Glutamate Signaling and Alterations in Learning, Attention, and Impulsivity Following Prenatal Nicotine Exposure

Autor: Tina Becher Østerbøg, Susana Aznar, Theis H. Ipsen, Maitane Caballero-Puntiverio, Jesper T. Andreasen, Kristi A. Kohlmeier, Filip S. Polli

Publikováno v: Molecular Neurobiology. 57:2002-2020

Over 70 million European pregnant women are smokers during their child-bearing years. Consumption of tobacco-containing products during pregnancy is associated with several negative behavioral outcomes for the offspring, including a higher susceptibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc55106b7f107c6ff89ca6c9a2cc41c7
https://doi.org/10.1007/s12035-019-01854-9

A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers

Autor: Natasha L. Mason, Theis H. Terwey, Johannes G. Ramaekers, Stefan W. Toennes, J. Reckweg, Cees J Van Leeuwen

Publikováno v: Frontiers in Pharmacology, 12:760671. Frontiers Media S.A.
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
European Psychiatry, 65, S716-S716. Elsevier France-Éditions Scientifiques et Medicales Elsevier

Introduction 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective studies for other tryptamines have suggested beneficial effects on mental health outcomes. Objecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40abb39de1dc199e77dd4bfdf27fb6c2
https://doi.org/10.3389/fphar.2021.760671