Linking Hypothermia and Altered Metabolism with TrkB Activation.

Autor: Alitalo O; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., González-Hernández G; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Rosenholm M; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Kohtala P; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Department of Psychiatry, Weill Cornell Medicine, New York, New York 10021, United States., Matsui N; Faculty of Pharmacy, Gifu University of Medical Science, 4-3-3 Nijigaoka, Kani, Gifu 509-0293, Japan., Müller HK; Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus N 8200, Denmark., Theilmann W; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland., Klein A; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK-2200, Denmark.; Department of Drug Design & Pharmacology, University of Copenhagen, Copenhagen DK-2100, Denmark., Kärkkäinen O; School of Pharmacy, University of Eastern Finland, Kuopio 70210, Finland.; Afekta Technologies Ltd., Kuopio 70210, Finland., Rozov S; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Rantamäki T; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Kohtala S; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Department of Psychiatry, Weill Cornell Medicine, New York, New York 10021, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2023 Sep 06; Vol. 14 (17), pp. 3212-3225. Date of Electronic Publication: 2023 Aug 08.

Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective.

Autor: Johne M; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany.; Center for Systems Neuroscience, Hannover, Germany., Römermann K; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany., Hampel P; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany.; Center for Systems Neuroscience, Hannover, Germany., Gailus B; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany.; Center for Systems Neuroscience, Hannover, Germany., Theilmann W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany., Ala-Kurikka T; Molecular and Integrative Biosciences and Neuroscience Center (HiLIFE), University of Helsinki, Helsinki, Finland., Kaila K; Molecular and Integrative Biosciences and Neuroscience Center (HiLIFE), University of Helsinki, Helsinki, Finland., Löscher W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany.; Center for Systems Neuroscience, Hannover, Germany.

Publikováno v: Epilepsia [Epilepsia] 2021 Apr; Vol. 62 (4), pp. 920-934. Date of Electronic Publication: 2020 Dec 01.

Impacts of Electroconvulsive Therapy on the Neurometabolic Activity in a Mice Model of Depression: An Ex Vivo 1 H-[ 13 C]-NMR Spectroscopy Study.

Autor: Sarawagi, Ajay^1,2 (AUTHOR) ajaysarawagi1997@gmail.com, Wadnerkar, Pratishtha¹ (AUTHOR) pratishtha.w@gmail.com, Keluskar, Vrundika¹ (AUTHOR) vrundikakeluskar9797@gmail.com, Ram, Narra Sai¹ (AUTHOR) sairamn@ccmb.res.in, Kumar, Jerald Mahesh¹ (AUTHOR) mahesh73@ccmb.res.in, Patel, Anant Bahadur^1,2 (AUTHOR) abpatel@ccmb.res.in

Publikováno v: Neuroglia. Sep2024, Vol. 5 Issue 3, p306-322. 17p.

Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex.

Autor: Theilmann W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany., Gericke B; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany., Schidlitzki A; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany., Muneeb Anjum SM; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany., Borsdorf S; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany., Harries T; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany., Roberds SL; Tuberous Sclerosis Alliance, Silver Spring, MD, USA., Aguiar DJ; Tuberous Sclerosis Alliance, Silver Spring, MD, USA., Brunner D; PsychoGenics, Paramus, NJ, USA., Leiser SC; PsychoGenics, Paramus, NJ, USA., Song D; PsychoGenics, Paramus, NJ, USA., Fabbro D; PIQUR Therapeutics AG, Basel, Switzerland., Hillmann P; PIQUR Therapeutics AG, Basel, Switzerland., Wymann MP; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland., Löscher W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address: wolfgang.loescher@tiho-hannover.de.

Publikováno v: Neuropharmacology [Neuropharmacology] 2020 Dec 01; Vol. 180, pp. 108297. Date of Electronic Publication: 2020 Sep 03.

Selective inhibition of mTORC1/2 or PI3K/mTORC1/2 signaling does not prevent or modify epilepsy in the intrahippocampal kainate mouse model.

Autor: Gericke B; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany., Brandt C; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Germany., Theilmann W; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Germany., Welzel L; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany., Schidlitzki A; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Germany., Twele F; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Germany., Kaczmarek E; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Germany., Anjum M; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany., Hillmann P; PIQUR Therapeutics AG, Basel, Switzerland., Löscher W; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address: wolfgang.loescher@tiho-hannover.de.

Publikováno v: Neuropharmacology [Neuropharmacology] 2020 Jan 01; Vol. 162, pp. 107817. Date of Electronic Publication: 2019 Oct 22.