Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling.

Autor: van Kuijk K; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Demandt JAF; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands., Perales-Patón J; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University, and Heidelberg University Hospital, Bioquant, Heidelberg, Germany.; Joint Research Centre for Computational Biomedicine (JRC COMBINE), Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Theelen TL; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands., Kuppe C; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Marsch E; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands., de Bruijn J; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands., Jin H; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands., Gijbels MJ; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands.; Department of Molecular Genetics, MUMC, Maastricht, Netherlands.; Department of Experimental Vascular Biology, Amsterdam UMC, Amsterdam, The Netherlands.; GROW-School for Oncology and Developmental Biology, MUMC, Maastricht, Netherlands., Matic L; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Mees BME; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Vascular Surgery, MUMC, Maastricht, Netherlands., Reutelingsperger CPM; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Biochemistry, MUMC, Maastricht, Netherlands., Hedin U; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Biessen EAL; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands.; Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany., Carmeliet P; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, VIB Center for Cancer biology, B-3000 Leuven, Belgium., Baker AH; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; BHF Centre for Cardiovascular Sciences (CVS), University of Edinburgh, Edinburgh, UK., Kramann RK; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands., Schurgers LJ; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Department of Biochemistry, MUMC, Maastricht, Netherlands., Saez-Rodriguez J; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University, and Heidelberg University Hospital, Bioquant, Heidelberg, Germany.; Joint Research Centre for Computational Biomedicine (JRC COMBINE), Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Sluimer JC; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands.; BHF Centre for Cardiovascular Sciences (CVS), University of Edinburgh, Edinburgh, UK.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2022 Mar 25; Vol. 118 (5), pp. 1232-1246.

Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice.

Autor: Demandt JAF; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands., van Kuijk K; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Theelen TL; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands., Marsch E; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands., Heffron SP; Center for the Prevention of Cardiovascular Disease, Department of Medicine, Grossman School of Medicine, New York University, New York, NY, United States., Fisher EA; Center for the Prevention of Cardiovascular Disease, Department of Medicine, Grossman School of Medicine, New York University, New York, NY, United States., Carmeliet P; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, Leuven, Belgium., Biessen EAL; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany., Sluimer JC; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; BHF Centre for Cardiovascular Sciences (CVS), University of Edinburgh, Edinburgh, United Kingdom.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 May 14; Vol. 9, pp. 664258. Date of Electronic Publication: 2021 May 14 (Print Publication: 2021).

Author Correction: Ablation of CD8α ⁺ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice.

Autor: Legein B; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands., Janssen EM; Division of Immunobiology, Cincinnati Children's Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, United States of America., Theelen TL; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands., Gijbels MJ; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands.; Experimental Vascular Biology, Dept. of Medical Biochemistry, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., Walraven J; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands., Klarquist JS; Division of Immunobiology, Cincinnati Children's Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, United States of America., Hennies CM; Division of Immunobiology, Cincinnati Children's Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, United States of America., Wouters K; Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands., Seijkens TTP; Experimental Vascular Biology, Dept. of Medical Biochemistry, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., Wijnands E; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands., Sluimer JC; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands., Lutgens E; Experimental Vascular Biology, Dept. of Medical Biochemistry, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.; Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilians University (LMU), Munich, Germany., Zenke M; Institute for Biomedical Engineering, Dept. of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany., Hildner K; Medical Immunology, Universitatsklinikum Erlangen, Erlangen, Germany., Biessen EAL; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands., Temmerman L; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands. lieve.temmerman@mumc.nl.

Publikováno v: Scientific reports [Sci Rep] 2020 May 26; Vol. 10 (1), pp. 8747. Date of Electronic Publication: 2020 May 26.

Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression.

Autor: Theodorou K; Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands., van der Vorst EPC; Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands.; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany., Gijbels MJ; Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands.; Department of Molecular Genetics, CARIM, Maastricht University, Maastricht, The Netherlands.; Department of Medical Biochemistry, AMC, Amsterdam, Netherlands., Wolfs IMJ; Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands., Jeurissen M; Department of Molecular Genetics, CARIM, Maastricht University, Maastricht, The Netherlands., Theelen TL; Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands., Sluimer JC; Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands., Wijnands E; Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands., Cleutjens JP; Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands., Li Y; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Jansen Y; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany., Weber C; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany.; Department of Biochemistry, CARIM, Maastricht University, Maastricht, Netherlands.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Ludwig A; Institute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany., Bentzon JF; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Bartsch JW; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Biessen EAL; Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands.; Institute for Molecular Cardiovascular Research, RWTH Aachen, Aachen, Germany., Donners MMPC; Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands. marjo.donners@maastrichtuniversity.nl.

Publikováno v: Scientific reports [Sci Rep] 2017 Sep 15; Vol. 7 (1), pp. 11670. Date of Electronic Publication: 2017 Sep 15.

Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8.

Autor: Laakkonen JP; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. johanna.p.laakkonen@uef.fi., Lappalainen JP; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Theelen TL; Department of Pathology, CARIM, Maastricht University Medical Center, Maastricht, The Netherlands., Toivanen PI; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Nieminen T; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Jauhiainen S; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Kaikkonen MU; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Sluimer JC; Department of Pathology, CARIM, Maastricht University Medical Center, Maastricht, The Netherlands., Ylä-Herttuala S; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

Publikováno v: Angiogenesis [Angiogenesis] 2017 Feb; Vol. 20 (1), pp. 109-124. Date of Electronic Publication: 2016 Nov 21.