In situ modeling of acquired resistance to RTK/RAS-pathway-targeted therapies

Autor: Sealover, Nancy E., Theard, Patricia L., Hughes, Jacob M., Linke, Amanda J., Daley, Brianna R., Kortum, Robert L.

Publikováno v: In iScience 19 January 2024 27(1)

Protocol for modeling acquired resistance to targeted therapeutics in adherent and suspension cancer cell lines via in situ resistance assay

Autor: Sealover, Nancy E., Hughes, Jacob M., Theard, Patricia L., Chatterjee, Deepan, Linke, Amanda J., Finniff, Bridget A., Daley, Brianna R., Lewis, Robert E., Kortum, Robert L.

Publikováno v: In STAR Protocols 20 December 2024 5(4)

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SOS2 regulates the threshold of mutant EGFR -dependent oncogenesis.

Autor: Theard PL; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 20814., Linke AJ; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 20814., Sealover NE; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 20814., Daley BR; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 20814., Yang J; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 20814., Cox K; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 20814., Kortum RL; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 20814.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 29. Date of Electronic Publication: 2023 Jun 29.