Výsledky vyhledávání - "Thean S, Chew"

Akademický článek

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

Autor: Thean S. Chew, Nuala R. O'Shea, Gavin W. Sewell, Stefan H. Oehlers, Claire M. Mulvey, Philip S. Crosier, Jasminka Godovac-Zimmermann, Stuart L. Bloom, Andrew M. Smith, Anthony W. Segal

Publikováno v: Disease Models & Mechanisms, Vol 8, Iss 8, Pp 817-829 (2015)

Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretio

Externí odkaz: https://doaj.org/article/76a40966cdef441c9f341dd421b8e284

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The effect of infliximab dose escalation in inflammatory bowel disease patients with antibodies to infliximab

Autor: Ravishankar Sargur, Graeme Wild, Laura Marshall, Laura Thompson, Melissa F Hale, Alison Wright, Gloria S. Z. Tun, Alan J Lobo, Thean S. Chew, AJ Brooks, Kerry H Robinson

Publikováno v: European Journal of Gastroenterology & Hepatology. 34:295-301

Infliximab dose escalation (DE) can be used in inflammatory bowel disease patient; however, the long-term benefit remains unclear, especially in those with antibodies to infliximab (ATI). The aim was to assess the effect of DE in patients with ATI on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638e40587cd402e3f7bdea169ba96048
https://doi.org/10.1097/meg.0000000000002289

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OWE-01 The effect of infliximab dose escalation in inflammatory bowel disease patients with antibodies to infliximab

Autor: AJ Brooks, Laura Marshall, Rebecca Campbell, Gloria S. Z. Tun, Kerry H Robinson, Thean S. Chew, Laura Thompson, Melissa F Hale, Alan J Lobo

Publikováno v: Inflammatory Bowel Disease.

Introduction Infliximab (IFX) dose escalation (DE) can be used in patients with inflammatory bowel disease with loss of response (LOR) or subtherapeutic drug levels. However, the long-term benefit of DE remains unclear, especially in those with antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4631e71fa2fdea83d0ded5cd25bb9a56
https://doi.org/10.1136/gutjnl-2019-bsgabstracts.122

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Impact of the coronavirus infectious disease (COVID-19) pandemic on the provision of inflammatory bowel disease (IBD) antenatal care and outcomes of pregnancies in women with IBD

Autor: Rachel Cooney, Alexandra Kent, Paul Collins, Thean S. Chew, Veronica Hall, Lyn A. Smith, Shaji Sebastian, Kamal Patel, Aileen Fraser, Melanie Gunn, Christian P. Selinger, Maya Roysam, Georgina Kerry, Jimmy K. Limdi, Aaron Bancil, Jonathan Segal, Helen Steed, Klaartje Kok

Publikováno v: BMJ Open Gastroenterology, Vol 8, Iss 1 (2021)
BMJ Open Gastroenterology

BackgroundThe impact of COVID-19 on pregnant inflammatory bowel disease (IBD) patients is currently unknown. Reconfiguration of services during the pandemic may negatively affect medical and obstetric care. We aimed to examine the impacts on IBD ante

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2d60cdee70ff63a4205ea450ebf89f
https://doi.org/10.1136/bmjgast-2021-000603

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Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation

Autor: Nuala R, O'Shea, Thean S, Chew, Jenny, Dunne, Rebecca, Marnane, Bahman, Nedjat-Shokouhi, Philip J, Smith, Stuart L, Bloom, Andrew M, Smith, Anthony W, Segal

Publikováno v: Journal of Crohn's & Colitis

Background and Aims: ADAM [A Disintegrin And Metalloproteinase] is a family of peptidase proteins which have diverse roles in tissue homeostasis and immunity. Here, we study ADAM-like DECysin-1 [ADAMDEC1] a unique member of the ADAM family. ADAMDEC1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06ebd2228878160379ef09055898c738
https://pubmed.ncbi.nlm.nih.gov/27226416

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Is there a role for routine duodenal biopsy in diagnosing giardiasis in a European population?

Autor: David S Sanders, Andrew D Hopper, Thean S. Chew

Publikováno v: Scandinavian Journal of Gastroenterology. 43:1219-1223

Giardia lamblia is the most common enteric protozoan world-wide. The prevalence varies internationally. Patients with giardiasis typically have diarrhoea but may have atypical symptoms when referred for endoscopy. The purpose of this study was to inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a5ada009f8bde91a130e0b3f31e58f
https://doi.org/10.1080/00365520802101853

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