Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Thean DGL"'
1
Akademický článek
Accurate top protein variant discovery via low-N pick-and-validate machine learning.
Autor: Chu HY; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Fong JHC; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Thean DGL; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Zhou P; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Fung FKC; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Huang Y; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Department of Statistics and Actuarial Science, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Wong ASL; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China. Electronic address: aslw@hku.hk.
Publikováno v: Cell systems [Cell Syst] 2024 Feb 21; Vol. 15 (2), pp. 193-203.e6. Date of Electronic Publication: 2024 Feb 09.
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2
Akademický článek
Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities.
Autor: Thean DGL; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China., Chu HY; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China.; Centre for Oncology and Immunology Limited, Hong Kong Science Park, Hong Kong, SAR, China., Fong JHC; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China., Chan BKC; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China.; Centre for Oncology and Immunology Limited, Hong Kong Science Park, Hong Kong, SAR, China., Zhou P; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China.; Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, SAR, China., Kwok CCS; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China., Chan YM; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, SAR, China., Mak SYL; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, SAR, China., Choi GCG; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China.; Centre for Oncology and Immunology Limited, Hong Kong Science Park, Hong Kong, SAR, China., Ho JWK; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China.; Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Park, Hong Kong, SAR, China., Zheng Z; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, SAR, China.; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, SAR, China.; Biotechnology and Health Centre, City University of Hong Kong Shenzhen Research Institute, Shenzhen, China., Wong ASL; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China. aslw@hku.hk.; Centre for Oncology and Immunology Limited, Hong Kong Science Park, Hong Kong, SAR, China. aslw@hku.hk.; Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, SAR, China. aslw@hku.hk.
Publikováno v: Nature communications [Nat Commun] 2022 Apr 25; Vol. 13 (1), pp. 2219. Date of Electronic Publication: 2022 Apr 25.
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3
Akademický článek
High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination.
Autor: Yuen CTL; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Thean DGL; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Chan BKC; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Zhou P; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Kwok CCS; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Chu HY; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Cheung MSH; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Wang B; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Chan YM; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China., Mak SYL; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China., Leung AY; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China.; Division of Haematology, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; The Jockey Club Centre for Clinical Innovation and Discovery, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Choi GCG; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Zheng Z; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong SAR, China.; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.; Biotechnology and Health Centre, City University of Hong Kong Shenzhen Research Institute, Shenzhen, China., Wong ASL; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China.; Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Feb 22; Vol. 50 (3), pp. 1650-1660.
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4
Akademický článek
Combinatorial genetics methods for discovering high-order regulatory combinations and engineering genetic drivers for neural differentiation.
Autor: Thean DGL; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China., Wong ASL; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences; Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Publikováno v: Neural regeneration research [Neural Regen Res] 2021 Dec; Vol. 16 (12), pp. 2403-2404.
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5
Akademický článek
Quantifying Protein-Nucleic Acid Interactions for Engineering Useful CRISPR-Cas9 Genome-Editing Variants.
Autor: Chu HY; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Peng J; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Mou Y; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Wong ASL; Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. aslw@hku.hk.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China. aslw@hku.hk.
Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2870, pp. 227-243.
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6
Akademický článek
CRISPR/Cas9: a powerful tool in colorectal cancer research.
Autor: Hu, Yang1 (AUTHOR), Liu, Liang2 (AUTHOR), Jiang, Qi3 (AUTHOR), Fang, Weiping1 (AUTHOR), Chen, Yazhu4 (AUTHOR) yazhu.chen@qq.com, Hong, Yuntian5 (AUTHOR) 3130101818@zju.edu.cn, Zhai, Xiang6 (AUTHOR) zx1996@whu.edu.cn
Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 11/22/2023, Vol. 42 Issue 1, p1-19. 19p.
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7
Akademický článek
Artificial intelligence-aided protein engineering: from topological data analysis to deep protein language models.
Autor: Qiu, Yuchi1 (AUTHOR), Wei, Guo-Wei1,2,3 (AUTHOR) weig@msu.edu
Publikováno v: Briefings in Bioinformatics. Sep2023, Vol. 24 Issue 5, p1-13. 13p.
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9
Akademický článek
Recent advances in therapeutic CRISPR-Cas9 genome editing: mechanisms and applications.
Autor: Zhou, Lifang, Yao, Shaohua
Publikováno v: Molecular Biomedicine; 4/7/2023, Vol. 4 Issue 1, p1-25, 25p
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10
Akademický článek
Engineered Staphylococcus auricularis Cas9 with high-fidelity.
Autor: Wei N; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai, China., Shang L; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai, China., Liu J; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai, China., Wang M; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai, China., Liu Y; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai, China., Zhu C; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China., Fei C; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai, China., Zhang L; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai, China., Yang F; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai, China., Gu F; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.; Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai, China.
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2023 Aug; Vol. 37 (8), pp. e23060.
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