Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thea van den Bosch"'
Autor:
Elisa Balboa, Tamara Marín, Juan Esteban Oyarzún, Pablo S. Contreras, Robert Hardt, Thea van den Bosch, Alejandra R. Alvarez, Boris Rebolledo-Jaramillo, Andres D. Klein, Dominic Winter, Silvana Zanlungo
Publikováno v:
Cells, Vol 10, Iss 8, p 2159 (2021)
Niemann-Pick type C disease (NPCD) is a lysosomal storage disorder caused by mutations in the NPC1 gene. The most affected tissues are the central nervous system and liver, and while significant efforts have been made to understand its neurological c
Externí odkaz:
https://doaj.org/article/bad4e229bef34b36b08551674950517c
Autor:
Marcel Kwiatkowski, Simon D. Pouwels, Frank J. Dekker, Rainer Bischoff, Nick H. T. ten Hacken, Peter Horvatovich, Frank Klont, Thea van den Bosch, Alen Faiz
Publikováno v:
Journal of Proteome Research, 20(11). NLM (Medline)
Journal of Proteome Research
Journal of Proteome Research
Affinity ligands such as antibodies are widely used in (bio)medical research for purifying proteins from complex biological samples. These ligands are generally immobilized onto solid supports which facilitate the separation of a captured protein fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5366c773fd80d932e0dc3f3bc026855
https://research.rug.nl/en/publications/ed028170-950c-4e64-9a78-619aa2273c47
https://research.rug.nl/en/publications/ed028170-950c-4e64-9a78-619aa2273c47
Autor:
Frank J. Dekker, Niek G. J. Leus, Alexander Dömling, Gebremedhin Solomon Hailu, Dante Rotili, Jos Hermans, Antonello Mai, Nikolaos Eleftheriadis, Rainer Bischoff, Thea van den Bosch, Hidde J. Haisma, Hannah Wapenaar, Petra E van der Wouden
Publikováno v:
European Journal of Medicinal Chemistry, 136, 480-486. ELSEVIER MASSON, CORPORATION OFFICE
Histone acetyltransferases (HATs) are important mediators of epigenetic post-translational modifications of histones that play important roles in health and disease. A disturbance of these modifications can result in disease states, such as cancer or
Autor:
Jos Hermans, Alexander P. Boichenko, Thea van den Bosch, Niek G. J. Leus, Rainer Bischoff, Frank J. Dekker, Hannah Wapenaar, Hidde J. Haisma
Publikováno v:
Pulmonary Pharmacology & Therapeutics, 44, 88-95. ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Lysine acetylations are post-translational modifications of cellular proteins, that are crucial in the regulation of many cellular processes. Lysine acetylations on histone proteins are part of the epigenetic code regulating gene expression and are i
Autor:
Hidde J. Haisma, Loes E. M. Kistemaker, Frank J. Dekker, Reinoud Gosens, Wouter T R Hooghiemstra, Petra E van der Wouden, Rainer Bischoff, Thea van den Bosch, Maria E. Ourailidou, Niek G. J. Leus
Publikováno v:
Biochemical Pharmacology
Biochemical Pharmacology, 58-74. PERGAMON-ELSEVIER SCIENCE LTD
STARTPAGE=58;ENDPAGE=74;ISSN=0006-2952;TITLE=Biochemical Pharmacology
Biochemical Pharmacology, 58-74. PERGAMON-ELSEVIER SCIENCE LTD
STARTPAGE=58;ENDPAGE=74;ISSN=0006-2952;TITLE=Biochemical Pharmacology
Graphical abstract
The increasing number of patients suffering from chronic obstructive pulmonary disease (COPD) represents a major and increasing health problem. Therefore, novel therapeutic approaches are needed. Class I HDACs 1, 2 and 3 play
The increasing number of patients suffering from chronic obstructive pulmonary disease (COPD) represents a major and increasing health problem. Therefore, novel therapeutic approaches are needed. Class I HDACs 1, 2 and 3 play
Autor:
Thea van den Bosch, Alexander P. Boichenko, Annalisa D’Urzo, Frank J. Dekker, Vincenza Andrisano, Jos Hermans, Rainer Bischoff
Publikováno v:
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, 408(13), 3547-3553. SPRINGER HEIDELBERG
Analytical and Bioanalytical Chemistry, 408(13), 3547-3553. SPRINGER HEIDELBERG
We developed a targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the site-specific quantification of lysine acetylation in the N-terminal region of histone H4 by combining chemical derivatization at the protein and peptide
Publikováno v:
Epigenomics. 9(7)
Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here
Autor:
Frank J. Dekker, Sophie Bos, Reinoud Gosens, Nikolaos Eleftheriadis, Rainer Bischoff, Niek G. J. Leus, Rutger A. F. Gjaltema, Hidde J. Haisma, Kim Krist, Petra E van der Wouden, Thea van den Bosch, Solomon A Mekonnen, Loes E. M. Kistemaker, Maria E. Ourailidou
Publikováno v:
Scientific Reports
Scientific Reports, 7:45047. Nature Publishing Group
Scientific Reports, 7:45047. Nature Publishing Group
Chronic obstructive pulmonary disease (COPD) constitutes a major health burden. Studying underlying molecular mechanisms could lead to new therapeutic targets. Macrophages are orchestrators of COPD, by releasing pro-inflammatory cytokines. This proce
Autor:
Hannah, Wapenaar, Thea, van den Bosch, Niek G J, Leus, Petra E, van der Wouden, Nikolaos, Eleftheriadis, Jos, Hermans, Gebremedhin Solomon, Hailu, Dante, Rotili, Antonello, Mai, Alexander, Dömling, Rainer, Bischoff, Hidde J, Haisma, Frank J, Dekker
Publikováno v:
European journal of medicinal chemistry. 136
Histone acetyltransferases (HATs) are important mediators of epigenetic post-translational modifications of histones that play important roles in health and disease. A disturbance of these modifications can result in disease states, such as cancer or
Autor:
Thea van den Bosch, Edzard M. Geertsema, Ellen Zandvoort, Gerrit J. Poelarends, Pim de Haan, Yufeng Miao, Mehran Rahimi, Jan-Ytzen van der Meer
Publikováno v:
Organic & Biomolecular Chemistry. ROYAL SOC CHEMISTRY
The enzyme 4-oxalocrotonate tautomerase (4-OT), which in nature catalyzes a tautomerization step as part of a catabolic pathway for aromatic hydrocarbons, was found to promiscuously catalyze different types of aldol reactions. These include the self-