Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Thea Shavlakadze"'
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28090 (2011)
Reasons for the progressive age-related loss of skeletal muscle mass and function, namely sarcopenia, are complex. Few studies describe sarcopenia in mice, although this species is the mammalian model of choice for genetic intervention and developmen
Externí odkaz:
https://doaj.org/article/f8ae235a9bf8457e965607b3f102f747
Autor:
Miranda D. Grounds, Hannah G. Radley-Crabb, Trevor Watson, Christopher D. McMahon, Thea Shavlakadze, Kenneth G. Matthews, Philip W. Sheard, Ruth Jinfen Chai, Zoe Soffe
Publikováno v:
Scandinavian Journal of Medicine & Science in Sports. 24:e423-435
The age-related loss of skeletal muscle mass and function is termed sarcopenia and has been attributed to a decline in concentrations of insulin-like growth factor-1 (IGF-1). We hypothesized that constitutively expressed IGF-1 within skeletal muscles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91fbb7290c080fc3c33cdb1082922403
https://doi.org/10.1111/sms.12200
https://doi.org/10.1111/sms.12200
Autor:
Thea Shavlakadze, Miranda D. Grounds
Publikováno v:
BioEssays. 33:458-468
We hypothesise that the sarcolemma of an actively growing myofibre has different properties to the sarcolemma of a mature adult myofibre. Such fundamentally different properties have clinical consequences for the onset, and potential therapeutic targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc0d515c7e98e0233b8651568dfe849
https://doi.org/10.1002/bies.201000136
https://doi.org/10.1002/bies.201000136
Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in mice
Publikováno v:
Biogerontology. 11:363-376
The ability of very old animals to make new muscle after injury remains controversial. This issue has major implications for the regenerative potential of damaged geriatric human muscle, to age-related loss of muscle mass (sarcopenia) and to the prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8466887b88cc68dcdac08643b4994242
https://doi.org/10.1007/s10522-009-9260-0
https://doi.org/10.1007/s10522-009-9260-0
Autor:
Peter Roberts, Marilyn Davies, Thea Shavlakadze, Miranda D. Grounds, Gayle M. Smythe, John Mcgeachie
Publikováno v:
Experimental Gerontology. 43:550-562
Injured skeletal muscle generally regenerates less efficiently with age, but little is understood about the effects of ageing on the very early inflammatory and neovascular events in the muscle repair process. This study used a total of 174 whole mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ea957d6998a49e11690a4f320de677
https://doi.org/10.1016/j.exger.2008.02.005
https://doi.org/10.1016/j.exger.2008.02.005
Autor:
Miranda D. Grounds, Thea Shavlakadze
Publikováno v:
BioEssays. 28:994-1009
Extreme loss of skeletal muscle mass (atrophy) occurs in human muscles that are not used. In striking contrast, skeletal muscles do not rapidly waste away in hibernating mammals such as bears, or aestivating frogs, subjected to many months of inactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c294b97e9f580ed60265757a8ed63c
https://doi.org/10.1002/bies.20479
https://doi.org/10.1002/bies.20479
Publikováno v:
Neuromuscular Disorders. 15:139-146
Loss of the nerve supply to skeletal muscle results in a relentless loss of muscle mass (atrophy) over time. The ability of insulin-like growth factor-1 to reduce atrophy resulting from denervation was examined after transection of the sciatic nerve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd33fff529a967937bf38e6539f3f85a
https://doi.org/10.1016/j.nmd.2004.10.013
https://doi.org/10.1016/j.nmd.2004.10.013
Publikováno v:
Molecular Therapy. 10:829-843
Necrosis of dystrophic myofibers in Duchenne muscular dystrophy and mdx mice results from defects in the subsarcolemmal protein dystrophin that cause membrane fragility and tears in the sarcolemma, and these lead to the destruction of the myofibers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ee86912f3e5c402265f1ede0ef8328
https://doi.org/10.1016/j.ymthe.2004.07.026
https://doi.org/10.1016/j.ymthe.2004.07.026
Ceroid and lipofuscin are autofluorescent granules thought to be generated as a consequence of chronic oxidative stress. Because ceroid and lipofuscin are persistent in tissue, their measurement can provide a lifetime history of exposure to chronic o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f59624e957f7714ff64489ebf3431c7
https://europepmc.org/articles/PMC3261605/
https://europepmc.org/articles/PMC3261605/
Autor:
Thea Shavlakadze, Hannah G. Radley-Crabb, Miranda D. Grounds, Jessica R. Terrill, Peter G. Arthur, Joanne N. Tonkin
Publikováno v:
Neuromuscular disorders : NMD. 22(2)
The extent of muscle pathology in sedentary adult mdx mice is very low and treadmill exercise is often used to increase myofibre necrosis; however, the early events in dystrophic muscle and blood in response to treadmill exercise (leading to myofibre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aea279ea4bfcf93271b9a99e4c23085
https://pubmed.ncbi.nlm.nih.gov/21835619
https://pubmed.ncbi.nlm.nih.gov/21835619