Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Thea J A M, van der Velden"'
Autor:
Kes H. Stevens, Laura M. Baas, Thea J. A. M. van der Velden, Romy N. Bouwmeester, Niels van Dillen, Eiske M. Dorresteijn, Arjan D. van Zuilen, Jack F. M. Wetzels, Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Lambertus P. van den Heuvel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare kidney disease caused by dysregulation of the complement alternative pathway. The complement dysregulation specifically leads to damage to the glomerular endothelium. To further understa
Externí odkaz:
https://doaj.org/article/f24ee56ed11d40e7b1eefbce5b1e6ba4
Autor:
Wouter J. C. Feitz, Romy Bouwmeester, Thea J. A. M. van der Velden, Susan Goorden, Christoph Licht, Lambert P. J. W. van den Heuvel, Nicole C. A. J. van de Kar
Publikováno v:
Microorganisms, Vol 9, Iss 10, p 2157 (2021)
In 90% of the cases, childhood hemolytic uremic syndrome (HUS) is caused by an infection with the Shiga toxin (Stx) producing E. coli bacteria (STEC-HUS). Stx preferentially binds to its receptor, the glycosphingolipid, globotriaosylceramide (Gb3), p
Externí odkaz:
https://doaj.org/article/494af96ddb7a437ba2b31e387ac46ae3
Autor:
Wouter J. C. Feitz, Petra A. van Setten, Thea J. A. M. van der Velden, Christoph Licht, Lambert P. J. W. van den Heuvel, Nicole C. A. J. van de Kar
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5615 (2021)
Hemolytic uremic syndrome (HUS) is characterized by a triad of symptoms consisting of hemolytic anemia, thrombocytopenia and acute renal failure. The most common form of HUS is caused by an infection with Shiga toxin (Stx) producing Escherichia coli
Externí odkaz:
https://doaj.org/article/6a0ba2f89edc48ab99ac87ea49291c9b
Autor:
Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Ramon M. van den Bos, Thea J. A. M. van der Velden, Sanne A. W. van Kraaij, Sebastian A. Sarlea, Valentina Gracchi, Michiel J. S. Oosterveld, Elena B. Volokhina, Lambertus P. W. J. van den Heuvel
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the comple
Externí odkaz:
https://doaj.org/article/d1c7b4a3090e49a8a90d6ce8788aba70
Autor:
Elena B. Volokhina, Wouter J. C. Feitz, Lonneke M. Elders, Thea J. A. M. van der Velden, Nicole C. A. J. van de Kar, Lambertus P. W. J. van den Heuvel
Publikováno v:
Toxins, Vol 12, Iss 7, p 435 (2020)
Hemolytic uremic syndrome (HUS) is a severe renal disease that is often preceded by infection with Shiga toxin (Stx)-producing Escherichia coli (STEC). The exact mechanism of Stx-mediated inflammation on human glomerular microvascular endothelial cel
Externí odkaz:
https://doaj.org/article/0426338df34e4197bdda8c3d329f49cb
Autor:
Wouter J. C. Feitz, Nicole C. A. J. van de Kar, Ian Cheong, Thea J. A. M. van der Velden, Carolina G. Ortiz-Sandoval, Dorothea Orth-Höller, Lambert P. J. W. van den Heuvel, Christoph Licht
Publikováno v:
Toxins, Vol 12, Iss 8, p 483 (2020)
Hemolytic uremic syndrome (HUS) is a rare disease primarily characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Endothelial damage is the hallmark of the pathogenesis of HUS with an infection with the Shiga toxin (Stx) produ
Externí odkaz:
https://doaj.org/article/5eb0a7aba7d740c988b3f38747293aad
Autor:
Susan T, Veissi, Bart, Smeets, Joanna A E, van Wijk, René, Classens, Thea J A M, van der Velden, Annelies, Jeronimus-Klaasen, Floor, Veltkamp, E M, Mak-Nienhuis, William, Morello, Giovanni, Montini, Antonia H M, Bouts, Lambertus P W J, van den Heuvel, Michiel F, Schreuder
Publikováno v:
Kidney international reports. 7(12)
The recurrence of proteinuria after kidney transplantation in patients with focal segmental glomerulosclerosis (FSGS) is considered proof of the presence of circulating permeability factors (CPFs). The aim of this study is to demonstrate the presence
Autor:
Elena B. Volokhina, Nicole C. A. J. van de Kar, Marloes A. H. M. Michels, Thea J A M van der Velden, Rianne J. F. Maas, Lambertus P. van den Heuvel
Publikováno v:
Journal of Immunology, 207, 2465-2472
Journal of Immunology, 207, 10, pp. 2465-2472
Journal of Immunology, 207, 10, pp. 2465-2472
The complement system is an important part of innate immunity. Complement activation leads to formation of convertase enzymes, switch of their specificity from C3 to C5 cleavage, and generation of lytic membrane attack complexes (C5b-9) on surfaces o
Autor:
Nicole C. A. J. van de Kar, Lambert P J W van den Heuvel, Christoph Licht, Thea J A M van der Velden, Wouter J C Feitz, Petra van Setten
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5615, p 5615 (2021)
International Journal of Molecular Sciences, 22
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, 22, 11
International Journal of Molecular Sciences, 22
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, 22, 11
Hemolytic uremic syndrome (HUS) is characterized by a triad of symptoms consisting of hemolytic anemia, thrombocytopenia and acute renal failure. The most common form of HUS is caused by an infection with Shiga toxin (Stx) producing Escherichia coli
Autor:
Thea J A M van der Velden, Kioa L. Wijnsma, Susan T. Veissi, Nicole C. A. J. van de Kar, Elena B. Volokhina, Sem de Wijs, L.P.W.J. van den Heuvel, Frank A. D. T. G. Wagener
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, 11
Frontiers in Immunology, 11
Shiga-toxin (Stx)-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children. Stx-mediated endothelial injury initiates the cascade leading to thrombotic microangiopathy (TMA),