The Shiga Toxin Receptor Globotriaosylceramide as Therapeutic Target in Shiga Toxin E. coli Mediated HUS

Autor: Wouter J. C. Feitz, Romy Bouwmeester, Thea J. A. M. van der Velden, Susan Goorden, Christoph Licht, Lambert P. J. W. van den Heuvel, Nicole C. A. J. van de Kar

Publikováno v: Microorganisms, Vol 9, Iss 10, p 2157 (2021)

In 90% of the cases, childhood hemolytic uremic syndrome (HUS) is caused by an infection with the Shiga toxin (Stx) producing E. coli bacteria (STEC-HUS). Stx preferentially binds to its receptor, the glycosphingolipid, globotriaosylceramide (Gb3), p

Externí odkaz: https://doaj.org/article/494af96ddb7a437ba2b31e387ac46ae3

Shiga Toxin Selectively Upregulates Expression of Syndecan-4 and Adhesion Molecule ICAM-1 in Human Glomerular Microvascular Endothelium

Autor: Elena B. Volokhina, Wouter J. C. Feitz, Lonneke M. Elders, Thea J. A. M. van der Velden, Nicole C. A. J. van de Kar, Lambertus P. W. J. van den Heuvel

Publikováno v: Toxins, Vol 12, Iss 7, p 435 (2020)

Hemolytic uremic syndrome (HUS) is a severe renal disease that is often preceded by infection with Shiga toxin (Stx)-producing Escherichia coli (STEC). The exact mechanism of Stx-mediated inflammation on human glomerular microvascular endothelial cel

Externí odkaz: https://doaj.org/article/0426338df34e4197bdda8c3d329f49cb

Circulating Permeability Factors in Focal Segmental Glomerulosclerosis

Autor: Susan T, Veissi, Bart, Smeets, Joanna A E, van Wijk, René, Classens, Thea J A M, van der Velden, Annelies, Jeronimus-Klaasen, Floor, Veltkamp, E M, Mak-Nienhuis, William, Morello, Giovanni, Montini, Antonia H M, Bouts, Lambertus P W J, van den Heuvel, Michiel F, Schreuder

Publikováno v: Kidney international reports. 7(12)

The recurrence of proteinuria after kidney transplantation in patients with focal segmental glomerulosclerosis (FSGS) is considered proof of the presence of circulating permeability factors (CPFs). The aim of this study is to demonstrate the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efeb63be1c16bbf3b119626c47713129
https://pubmed.ncbi.nlm.nih.gov/36506233

Cell Biological Responses after Shiga Toxin-1 Exposure to Primary Human Glomerular Microvascular Endothelial Cells from Pediatric and Adult Origin

Autor: Nicole C. A. J. van de Kar, Lambert P J W van den Heuvel, Christoph Licht, Thea J A M van der Velden, Wouter J C Feitz, Petra van Setten

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 5615, p 5615 (2021)
International Journal of Molecular Sciences, 22
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, 22, 11

Hemolytic uremic syndrome (HUS) is characterized by a triad of symptoms consisting of hemolytic anemia, thrombocytopenia and acute renal failure. The most common form of HUS is caused by an infection with Shiga toxin (Stx) producing Escherichia coli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a37231b5cab6fcff6c8ddc79e42ce6
https://doi.org/10.3390/ijms22115615

Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome

Autor: Jack F.M. Wetzels, Tom Eirik Mollnes, Lambertus P. van den Heuvel, Dineke Westra, Elena B. Volokhina, Grethe Bergseth, Nicole C. A. J. van de Kar, Thea J A M van der Velden

Publikováno v: Clinical Immunology
Clinical Immunology, 160, 237-43
Clinical Immunology, 160, 2, pp. 237-43

Complement C5 inhibitor eculizumab treatment in atypical hemolytic uremic syndrome is effective, but associated with high costs. Complement inhibition monitoring in these patients has not been standardized. In this study we evaluated novel functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e300bd4124f420182af019c0d8c7f7f
https://hdl.handle.net/2066/153941