Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Thea Bunsen"'
Autor:
Marlene Tacke, Thomas Reinheckel, Christian P. Sommerhoff, Marianne Jochum, Simon F. Schuster, Steffen Kraus, Dorit K. Nägler, Thea Bunsen, Monika A. Cichoń
Publikováno v:
European Journal of Cell Biology. 90:678-686
Cellular senescence represents a powerful tumor suppressor mechanism to prevent proliferation and invasion of malignant cells. Since tumor cells as well as primary fibroblasts lacking the lysosomal cysteine-type carboxypeptidase cathepsin X exhibit a
Publikováno v:
Biological chemistry. 393(12)
The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of