Výsledky vyhledávání - "Thea A. Egelhofer"

Akademický článek

Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis

Autor: Tomoko M. Tabuchi, Andreas Rechtsteiner, Tess E. Jeffers, Thea A. Egelhofer, Coleen T. Murphy, Susan Strome

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Paternal contributions to epigenetic inheritance via nucleosomes are poorly understood, as sperm in many organisms replace the majority of nucleosomes with protamines. Here the authors provide evidence that Caenorhabditis elegans sperm retain histone

Externí odkaz: https://doaj.org/article/6906323daf014ef6b1261b6b2dfbf647

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Akademický článek

Antagonism between MES-4 and Polycomb Repressive Complex 2 Promotes Appropriate Gene Expression in C. elegans Germ Cells

Autor: Laura J. Gaydos, Andreas Rechtsteiner, Thea A. Egelhofer, Coleen R. Carroll, Susan Strome

Publikováno v: Cell Reports, Vol 2, Iss 5, Pp 1169-1177 (2012)

The Caenorhabditis elegans MES proteins are key chromatin regulators of the germline. MES-2, MES-3, and MES-6 form the C. elegans Polycomb repressive complex 2 and generate repressive H3K27me3. MES-4 generates H3K36me3 on germline-expressed genes. Tr

Externí odkaz: https://doaj.org/article/2995290c85e24decb08efb22ca9e4fb2

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Sperm-inherited H3K27me3 epialleles are transmitted transgenerationally incis

Autor: Kiyomi Raye Kaneshiro, Thea A. Egelhofer, Andreas Rechtsteiner, Chad Cockrum, Susan Strome

Publikováno v: Proceedings of the National Academy of Sciences. 119

The transmission of chromatin states from parent cells to daughter cells preserves cell-specific transcriptional states and thus cell identity through cell division. The mechanism that underpins this process is not fully understood. The role that chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626ebed5137b5b6cf23afe04c2736492
https://doi.org/10.1073/pnas.2209471119

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Repression of Germline Genes in Caenorhabditis elegans Somatic Tissues by H3K9 Dimethylation of Their Promoters

Autor: Susan Strome, Lisa N. Petrella, Thea A. Egelhofer, Andreas Rechtsteiner, Meghan Elizabeth Costello, Jocob M. Garrigues

Publikováno v: Genetics, vol 212, iss 1
Rechtsteiner, Andreas; Costello, Meghan E; Egelhofer, Thea A; Garrigues, Jacob M; Strome, Susan; & Petrella, Lisa N. (2019). Repression of Germline Genes in Caenorhabditis elegans Somatic Tissues by H3K9 Dimethylation of Their Promoters.. Genetics, genetics.301878.2018-genetics.301878.2018. doi: 10.1534/genetics.118.301878. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/20m836r9
Genetics

Repression of germline-promoting genes in somatic cells is critical for somatic development and function. To study how germline genes are repressed in somatic tissues, we analyzed key histone modifications in three Caenorhabditis elegans synMuv B mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85301c2d5afddbcb8151c208402e8f1
https://doi.org/10.1534/genetics.118.301878

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Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis

Autor: Susan Strome, Tess E. Jeffers, Andreas Rechtsteiner, Coleen T. Murphy, Thea A. Egelhofer, Tomoko M. Tabuchi

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature communications, vol 9, iss 1

Paternal contributions to epigenetic inheritance are not well understood. Paternal contributions via marked nucleosomes are particularly understudied, in part because sperm in some organisms replace the majority of nucleosome packaging with protamine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6dd8c9d025c79d2efdaafdc6499fb7
https://doaj.org/article/6906323daf014ef6b1261b6b2dfbf647

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NONU-1 encodes a conserved endonuclease required for mRNA translation surveillance

Autor: Joshua A. Arribere, Marissa L Glover, L. Aravind, A. Maxwell Burroughs, Makena N Pule, Thea A. Egelhofer

Cellular translation surveillance rescues ribosomes that stall on problematic mRNAs. During translation surveillance, endonucleolytic cleavage of the problematic mRNA is a critical step in rescuing stalled ribosomes. However, the nuclease(s) responsi

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NONU-1 Encodes a Conserved Endonuclease Required for mRNA Translation Surveillance

Autor: Marissa L Glover, A. Maxwell Burroughs, Thea A. Egelhofer, L. Aravind, Parissa C. Monem, Joshua A. Arribere, Makena N Pule

Publikováno v: Cell reports, vol 30, iss 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9edf1c01f819a75f1bb7b3c56161e3a0
https://doi.org/10.1016/j.celrep.2020.03.023

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Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline

Autor: Andrew Kekūpa'a Knutson, Susan Strome, Thea A. Egelhofer, Andreas Rechtsteiner

Publikováno v: Genetics, vol 206, iss 1
Knutson, AK; Egelhofer, T; Rechtsteiner, A; & Strome, S. (2017). Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline. GENETICS, 206(1), 163-178. doi: 10.1534/genetics.116.198549. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/9tr7t849

Germ granules are widely conserved, germ-cell-specific, ribonucleo protein organelles. In C. elegans, germ granules (P granules) are necessary for fertility... The germ cells of multicellular organisms protect their developmental potential through sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7436d39069611c9b2cf0dfa966a1f9f3
https://escholarship.org/uc/item/9tr7t849

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Germ-Granule Components Prevent Somatic Development in the C. elegans Germline

Autor: Susan Strome, Thea A. Egelhofer, Dustin L. Updike, Andrew Kekūpa'a Knutson, Anne C. Campbell

Publikováno v: Updike, DL; Knutson, AKA; Egelhofer, TA; Campbell, AC; & Strome, S. (2014). Germ-granule components prevent somatic development in the C. Elegans germline. Current Biology, 24(9), 970-975. doi: 10.1016/j.cub.2014.03.015. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/4xp4v8r6
Current biology : CB, vol 24, iss 9

Specialized ribonucleoprotein organelles collectively known as germ granules are found in the germline cytoplasm from worms to humans [1]. In Drosophila, germ granules have been implicated in germline determination [2]. C. Elegans germ granules, know

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0fc0c597565e4c3789838561cfc424
https://doi.org/10.1016/j.cub.2014.03.015

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Germ granules prevent accumulation of somatic transcripts in the adult C. elegans germline

Autor: Susan Strome, Thea A. Egelhofer, Andrew Kekūpa'a Knutson, Andreas Rechtsteiner

The germ cells of multicellular organisms protect their developmental potential through specialized mechanisms. A shared feature of germ cells from worms to humans is the presence of non-membrane-bound ribonucleoprotein organelles called germ granule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f786cd8b6dd6beb16a290fd4008ad17e

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