Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer

Autor: Painter, Jodie N, O'Mara, Tracy A, Marquart, Louise, Webb, Penelope M, Attia, John, Medland, Sarah E, Cheng, Timothy, Dennis, Joe, Holliday, Elizabeth G, McEvoy, Mark, Scott, Rodney J, Ahmed, Shahana, Healey, Catherine S, Shah, Mitul, Gorman, Maggie, Martin, Lynn, Hodgson, Shirley V, Beckmann, Matthias W, Ekici, Arif B, Fasching, Peter A, Hein, Alexander, Rübner, Matthias, Czene, Kamila, Darabi, Hatef, Hall, Per, Li, Jingmei, Dörk, Thilo, Dürst, Matthias, Hillemanns, Peter, Runnebaum, Ingo B, Amant, Frederic, Annibali, Daniela, Depreeuw, Jeroen, Lambrechts, Diether, Neven, Patrick, Cunningham, Julie M, Dowdy, Sean C, Goode, Ellen L, Fridley, Brooke L, Winham, Stacey J, Njølstad, Tormund S, Salvesen, Helga B, Trovik, Jone, Werner, Henrica MJ, Ashton, Katie A, Otton, Geoffrey, Proietto, Anthony, Mints, Miriam, Tham, Emma, Bolla, Manjeet K, Michailidou, Kyriaki, Wang, Qin, Tyrer, Jonathan P, Hopper, John L, Peto, Julian, Swerdlow, Anthony J, Burwinkel, Barbara, Brenner, Hermann, Meindl, Alfons, Brauch, Hiltrud, Lindblom, Annika, Chang-Claude, Jenny, Couch, Fergus J, Giles, Graham G, Kristensen, Vessela N, Cox, Angela, Pharoah, Paul DP, Tomlinson, Ian, Dunning, Alison M, Easton, Douglas F, Thompson, Deborah J, Spurdle, Amanda B, AOCS Group, for RENDOCAS, National Study of Endometrial Cancer Genetics Group (NSECG), Australian National Endometrial Cancer Study Group (ANECS)

BACKGROUND: The strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with endometrial cancer risk, independent of measured BMI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a2bcc5f54d715225ff97c9b16329754e
https://openaccess.sgul.ac.uk/id/eprint/113823/1/Painter_et_al-2016-Cancer_Epidemiology_Biomarkers_and_Prevention-AM.pdf

Five endometrial cancer risk loci identified through genome-wide association analysis

Autor: Cheng, THT, Thompson, DJ, O'Mara, TA, Painter, JN, Glubb, DM, Flach, S, Lewis, A, French, JD, Freeman-Mills, L, Church, D, Gorman, M, Martin, L, National Study of Endometrial Cancer Genetics Group (NSECG), Hodgson, S, Webb, PM, Australian National Endometrial Cancer Study Group (ANECS), Attia, J, Holliday, EG, McEvoy, M, Scott, RJ, Henders, AK, Martin, NG, Montgomery, GW, Nyholt, DR, Ahmed, S, Healey, CS, Shah, M, Dennis, J, Fasching, PA, Beckmann, MW, Hein, A, Ekici, AB, Hall, P, Czene, K, Darabi, H, Li, J, Dörk, T, Dürst, M, Hillemanns, P, Runnebaum, I, Amant, F, Schrauwen, S, Zhao, H, Lambrechts, D, Depreeuw, J, Dowdy, SC, Goode, EL, Fridley, BL, Winham, SJ, Njølstad, TS, Salvesen, HB, Trovik, J, Werner, HMJ, Ashton, K, Otton, G, Proietto, T, Liu, T, Mints, M, Tham, E, RENDOCAS, CHIBCHA Consortium, Li, MJ, Yip, SH, Wang, J, Bolla, MK, Michailidou, K, Wang, Q, Tyrer, JP, Dunlop, M, Houlston, R, Palles, C, Hopper, JL, AOCS Group, Peto, J, Swerdlow, AJ, Burwinkel, B, Brenner, H, Meindl, A, Brauch, H, Lindblom, A, Chang-Claude, J, Couch, FJ, Giles, GG, Kristensen, VN, Cox, A, Cunningham, JM, Pharoah, PDP, Dunning, AM, Edwards, SL, Easton, DF, Tomlinson, I, Spurdle, AB

Publikováno v: Nature Genetics

We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. Genome-wide imputation and meta-analysis identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::adc9037f5b68ccd4fb6d96ab697f2376
https://researchonline.lshtm.ac.uk/id/eprint/2551460/1/Cheng_etal_2016_Five_endometrial_cancer_risk_loci_identified_through_genome_wide_association_analysis.pdf

Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer

Autor: O'Mara, Tracy A, Glubb, Dylan M, Painter, Jodie N, Cheng, Timothy, Dennis, Joe, Australian National Endometrial Cancer Study Group (ANECS), Attia, John, Holliday, Elizabeth G, McEvoy, Mark, Scott, Rodney J, Ashton, Katie, Proietto, Tony, Otton, Geoffrey, Shah, Mitul, Ahmed, Shahana, Healey, Catherine S, Gorman, Maggie, Martin, Lynn, National Study of Endometrial Cancer Genetics Group (NSECG), Hodgson, Shirley, Fasching, Peter A, Hein, Alexander, Beckmann, Matthias W, Ekici, Arif B, Hall, Per, Czene, Kamila, Darabi, Hatef, Li, Jingmei, Dürst, Matthias, Runnebaum, Ingo, Hillemanns, Peter, Dörk, Thilo, Lambrechts, Diether, Depreeuw, Jeroen, Annibali, Daniela, Amant, Frederic, Zhao, Hui, Goode, Ellen L, Dowdy, Sean C, Fridley, Brooke L, Winham, Stacey J, Salvesen, Helga B, Njølstad, Tormund S, Trovik, Jone, Werner, Henrica MJ, Tham, Emma, Liu, Tao, Mints, Miriam, RENDOCAS, Bolla, Manjeet K, Michailidou, Kyriaki, Tyrer, Jonathan P, Wang, Qin, Hopper, John L, AOCS Group, Peto, Julian, Swerdlow, Anthony J, Burwinkel, Barbara, Brenner, Hermann, Meindl, Alfons, Brauch, Hiltrud, Lindblom, Annika, Chang-Claude, Jenny, Couch, Fergus J, Giles, Graham G, Kristensen, Vessela N, Cox, Angela, Pharoah, Paul DP, Dunning, Alison M, Tomlinson, Ian, Easton, Douglas F, Thompson, Deborah J, Spurdle, Amanda B

Excessive exposure to estrogen is a well-established risk factor for endometrial cancer (EC), particularly for cancers of endometrioid histology. The physiological function of estrogen is primarily mediated by estrogen receptor alpha, encoded by ESR1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::bd2ecd6d0ce74e6428d2462b5ca04538
https://www.repository.cam.ac.uk/handle/1810/250467

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk

Autor: Painter, Jodie N, O'Mara, Tracy A, Batra, Jyotsna, Cheng, Timothy, Lose, Felicity A, Dennis, Joe, Michailidou, Kyriaki, Tyrer, Jonathan P, Ahmed, Shahana, Ferguson, Kaltin, Healey, Catherine S, Kaufmann, Susanne, Hillman, Kristine M, Walpole, Carina, Moya, Leire, Pollock, Pamela, Jones, Angela, Howarth, Kimberley, Martin, Lynn, Gorman, Maggie, Hodgson, Shirley, National Study of Endometrial Cancer Genetics Group (NSECG), CHIBCHA Consortium, De Polanco, Ma Magdalena Echeverry, Sans, Monica, Carracedo, Angel, Castellvi-Bel, Sergi, Rojas-Martinez, Augusto, Santos, Erika, Teixeira, Manuel R, Carvajal-Carmona, Luis, Shu, Xiao-Ou, Long, Jirong, Zheng, Wei, Xiang, Yong-Bing, Australian National Endometrial Cancer Study Group (ANECS), Montgomery, Grant W, Webb, Penelope M, Scott, Rodney J, McEvoy, Mark, Attia, John, Holliday, Elizabeth, Martin, Nicholas G, Nyholt, Dale R, Henders, Anjali K, Fasching, Peter A, Hein, Alexander, Beckmann, Matthias W, Renner, Stefan P, Dörk, Thilo, Hillemanns, Peter, Dürst, Matthias, Runnebaum, Ingo, Lambrechts, Diether, Coenegrachts, Lieve, Schrauwen, Stefanie, Amant, Frederic, Winterhoff, Boris, Dowdy, Sean C, Goode, Ellen L, Teoman, Attila, Salvesen, Helga B, Trovik, Jone, Njolstad, Tormund S, Werner, Henrica MJ, Ashton, Katie, Proietto, Tony, Otton, Geoffrey, Tzortzatos, Gerasimos, Mints, Miriam, Tham, Emma, RENDOCAS, Hall, Per, Czene, Kamila, Liu, Jianjun, Li, Jingmei, Hopper, John L, Southey, Melissa C, Australian Ovarian Cancer Study (AOCS), Ekici, Arif B, Ruebner, Matthias, Johnson, Nicola, Peto, Julian, Burwinkel, Barbara, Marme, Frederik, Brenner, Hermann, Dieffenbach, Aida K, Meindl, Alfons, Brauch, Hiltrud, GENICA Network, Lindblom, Annika, Depreeuw, Jeroen, Moisse, Matthieu, Chang-Claude, Jenny, Rudolph, Anja, Couch, Fergus J, Olson, Janet E, Giles, Graham G, Bruinsma, Fiona, Cunningham, Julie M

Publikováno v: Human molecular genetics, vol 24, iss 5

Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::41e272dc9d96e640caf06ed36634f1b9
https://escholarship.org/uc/item/8dj6n115

GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer

Autor: Mm, Chen, Mara Ta, O., Dj, Thompson, Jn, Painter, Australian National Endometrial Cancer Study Group (ANECS), Attia J, Black A, Brinton L, Chanock S, Chen C, Th, Cheng, Ls, Cook, Marta Crous-Bou, Doherty J, Cm, Friedenreich, Garcia-Closas M, Mm, Gaudet, Gorman M, Haiman C, Se, Hankinson

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6131656d6b299789e2720335eb7dabfb
http://europepmc.org/abstract/med/27008869