Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes

Autor: Maria Dehli Vigeland, Siri Tennebø Flåm, Magnus Dehli Vigeland, Ansgar Espeland, Manuela Zucknick, Monica Wigemyr, Lars Christian Haugli Bråten, Elisabeth Gjefsen, John-Anker Zwart, Kjersti Storheim, Linda Margareth Pedersen, Kaja Selmer, Benedicte Alexandra Lie, Kristina Gervin, The AIM Study Group

Publikováno v: Antibiotics, Vol 12, Iss 7, p 1217 (2023)

Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patien

Externí odkaz: https://doaj.org/article/642167277b8c4e4eafaa4d874192c719

Association of Modic change types and their short tau inversion recovery signals with clinical characteristics : a cross sectional study of chronic low back pain patients in the AIM-study

Autor: Lars Christian Haugli Bråten, Elina Iordanova Schistad, Ansgar Espeland, Per Martin Kristoffersen, Anne Julsrud Haugen, Gunn Hege Marchand, Nils Vetti, Are Hugo Pripp, Thomas Istvan Kadar, Jan Sture Skouen, Margreth Grotle, Lars Grøvle, John-Anker Zwart, Jens Ivar Brox, Kjersti Storheim, The AIM-study group

Publikováno v: BMC Musculoskeletal Disorders
BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-10 (2020)

Background Modic Changes (MCs, magnetic resonance imaging (MRI) signal changes in the vertebral bone marrow extending from the vertebral endplate) may represent a subgroup of nonspecific chronic low back pain that could benefit from a specific manage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87649729d1ce2c13b850cf3964a462a6
https://hdl.handle.net/11250/3059043

Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - secondary analyses of a randomised, placebo-controlled trial (the AIM study).

Autor: Bråten, Lars Christian Haugli, Grøvle, Lars, Espeland, Ansgar, Pripp, Are Hugo, Grotle, Margreth, Helllum, Christian, Haugen, Anne Julsrud, Froholdt, Anne, Rolfsen, Mads Peder, Nygaard, Øystein Petter, Lutro, Olav, Kristoffersen, Per Martin, Anke, Audny, Schistad, Elina Iordanova, Skouen, Jan Sture, Brox, Jens Ivar, Zwart, John-Anker, Storheim, Kjersti, The AIM-study group, Wilhelmsen, Maja

Publikováno v: BMC Musculoskeletal Disorders; 7/13/2020, Vol. 21 Issue 1, p1-11, 11p, 5 Charts

Letter to the Editor regarding, "Chronic low back pain, bacterial infection, and treatment with antibiotics".

Autor: Bråten, Lars Christian Haugli¹ (AUTHOR) l.c.h.braten@studmed.uio.no, Storheim, Kjersti¹ (AUTHOR), AIM study group (CORPORATE AUTHOR)

Publikováno v: Spine Journal. Jul2021, Vol. 21 Issue 7, p1229-1230. 2p.

Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes.

Autor: Vigeland MD; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.; Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway., Flåm ST; Department of Medical Genetics, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway., Vigeland MD; Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway., Espeland A; Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway.; Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway., Zucknick M; Oslo Centre for Biostatistics and Epidemiology, University of Oslo, 0313 Oslo, Norway., Wigemyr M; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway., Bråten LCH; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway., Gjefsen E; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.; Faculty of Medicine, University of Oslo, 0313 Oslo, Norway., Zwart JA; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.; Faculty of Medicine, University of Oslo, 0313 Oslo, Norway., Storheim K; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.; Department of Physiotherapy, Oslo Metropolitan University, 0167 Oslo, Norway., Pedersen LM; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.; Department of Physiotherapy, Oslo Metropolitan University, 0167 Oslo, Norway., Selmer K; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.; Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.; National Center for Epilepsy, Oslo University Hospital, 1337 Sandvika, Norway., Lie BA; Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway., Gervin K; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.; Pharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, School of Pharmacy, University of Oslo, 0313 Oslo, Norway., The Aim Study Group; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.

Publikováno v: Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2023 Jul 21; Vol. 12 (7). Date of Electronic Publication: 2023 Jul 21.