Valproic acid ameliorates morpho-dysfunctional effects triggered by Ischiatic nerve crush injury-induced by compression model in mice: Nerve regeneration and immune-modulatory pathway

Autor: Viviane de Oliveira e Souza, Tiago Bastos Taboada, Bruna Dos Santos Ramalho, Greice Nascimento Pires, Thayse Pinheiro Da Costa, Marcia Cury El-Cheikh, Katia Carneiro, Ana Maria Blanco Martinez

Publikováno v: Brain Research Bulletin, Vol 220, Iss , Pp 111140- (2025)

Peripheral nerve injuries are extremely severe and may lead to permanent disability, despite the regenerative capacity of the peripheral nervous system (PNS). To date, there is no established pharmacological therapy capable of predicting functional r

Externí odkaz: https://doaj.org/article/1dd4933366334f6fb5b33394b0415ad9

Epigenetic Therapy as a Putative Molecular Target to Modulate B Cell Biology and Behavior in the Context of Immunological Disorders

Autor: Thayse Pinheiro da Costa, Marcia Cury El-Cheikh, Katia Carneiro

Publikováno v: Journal of Immunology Research, Vol 2020 (2020)

Histone Deacetylase- (HDAC-) dependent epigenetic mechanisms have been widely explored in the last decade in different types of malignancies in preclinical studies. This effort led to the discovery and development of a range of new HDAC inhibitors (i

Externí odkaz: https://doaj.org/article/528ceeea52b6416e9ff0c26578f6bb12

5-Fluorouracil disrupts ovarian preantral follicles in young C57BL6J mice

Autor: A.C.A. Ferreira, Laritza Ferreira de Lima, C. Maside, Ramon da Silva Raposo, L.A. Vieira, Valdevane Rocha Araújo, José G. Abreu, Thayse Pinheiro da Costa, José Ricardo de Figueiredo, Juliana Zani de Almeida, Sônia Nair Báo, Reinaldo B. Oriá, Cláudio Cabral Campello, Ana Beatriz Graça Duarte, Luiz F. S. Oliveira

Publikováno v: Cancer Chemotherapy and Pharmacology. 87:567-578

5-Fluorouracil (5-FU), an anti-cancer drug, has been used for hepatoblastoma (HB) chemotherapy in children, who may have impaired ovarian follicle pool reserve with lasting effects to reproduction. Therefore, this study aimed to investigate 5-FU effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62ae18ab45bd1f24ee681df1e70eafc3
https://doi.org/10.1007/s00280-020-04217-7

Epigenetic Therapy as a Putative Molecular Target to Modulate B Cell Biology and Behavior in the Context of Immunological Disorders

Autor: Márcia C. El-Cheikh, Thayse Pinheiro da Costa, Katia Carneiro

Publikováno v: Journal of Immunology Research
Journal of Immunology Research, Vol 2020 (2020)

Histone Deacetylase- (HDAC-) dependent epigenetic mechanisms have been widely explored in the last decade in different types of malignancies in preclinical studies. This effort led to the discovery and development of a range of new HDAC inhibitors (i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee9a981055ff2dbcea419b4d83fa1dd
http://europepmc.org/articles/PMC7031723

Lack of galectin-3 modifies differentially Notch ligands in bone marrow and spleen stromal cells interfering with B cell differentiation

Autor: Marise Lopes Fermino, Thayse Pinheiro da Costa, Camila Brand, Márcia C. El-Cheikh, Lauremilia Ricon, Sofia Nascimento dos Santos, Felipe Leite de Oliveira, Jonathas Xavier Pereira, Roger Chammas, Emerson Soares Bernardes

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Galectin-3 (Gal-3) is a β-galactoside binding protein that controls cell-cell and cell-extracellular matrix interactions. In lymphoid organs, gal-3 inhibits B cell differentiation by mechanisms poorly understood. The B cell development is dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec439ba85655776d79a53cc2c374ebfb
https://pubmed.ncbi.nlm.nih.gov/29472568