Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Thayalan Navaratnam"'
Autor:
Pavel Strop, Arvind Rajpal, David L. Shelton, Jaume Pons, Christopher J. O'Donnell, Davide Foletti, Shu-Hui Liu, Kathy Delaria, Thomas-Toan Tran, Meritxell Galindo Casas, Adela Hasa-Moreno, Victor Lui, Thayalan Navaratnam, Dahui Zhou, Santiago E. Farias, Ludivine Moine, Russell Dushin, Magdalena Dorywalska
Experimental Procedures for the Preparation of Linker-Payloads.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a221c603c7097472189eaf46ce305d
https://doi.org/10.1158/1535-7163.22508245.v1
https://doi.org/10.1158/1535-7163.22508245.v1
Autor:
Pavel Strop, Arvind Rajpal, David L. Shelton, Jaume Pons, Christopher J. O'Donnell, Davide Foletti, Shu-Hui Liu, Kathy Delaria, Thomas-Toan Tran, Meritxell Galindo Casas, Adela Hasa-Moreno, Victor Lui, Thayalan Navaratnam, Dahui Zhou, Santiago E. Farias, Ludivine Moine, Russell Dushin, Magdalena Dorywalska
S1. Enrichment of VC-PABC hydrolysis activity by mouse serum fractionation. S2. Testing of mouse serum enzymes for the VC-PABC linker hydrolysis activity. S3. Testing of mouse serum enzymes for cleavage activity towards the non-cleavable amino-PEG6-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07f5767e7793d3073dc403b33870b7e
https://doi.org/10.1158/1535-7163.22508248
https://doi.org/10.1158/1535-7163.22508248
Autor:
Benjamin Adam Fish, Patrick B. Mullins, Christopher W. am Ende, Thayalan Navaratnam, Tuan P. Tran, Michael Eric Green, Chakrapani Subramanyam, Martin Pettersson, Christopher J. O’Donnell, Kathleen M. Wood, Longfei Xie, Liming Zhang, Douglas S. Johnson, Leslie R. Pustilnik, Kelly R. Bales, Subas M. Sakya, Gregory W. Kauffman, Cory Michael Stiff, Beth C. Vetelino, Ricardo Lira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2906-2911
We report the discovery and optimization of a novel series of dihydrobenzofuran amides as γ-secretase modulators (GSMs). Strategies for aligning in vitro potency with drug-like physicochemical properties and good microsomal stability while avoiding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e165d1fced0c65a288f1c260e2c8c06
https://doi.org/10.1016/j.bmcl.2012.02.059
https://doi.org/10.1016/j.bmcl.2012.02.059
Autor:
Magdalena Dorywalska, Davide Foletti, Kathy Delaria, Russell Dushin, Pavel Strop, Victor Lui, Jaume Pons, Dahui Zhou, Santiago E. Farias, David L. Shelton, Adela Hasa-Moreno, Thayalan Navaratnam, Ludivine Moine, Meritxell Galindo Casas, Thomas-Toan Tran, Arvind Rajpal, Christopher J. O’Donnell, Shu-Hui Liu
Publikováno v:
Molecular cancer therapeutics. 15(5)
The degree of stability of antibody–drug linkers in systemic circulation, and the rate of their intracellular processing within target cancer cells are among the key factors determining the efficacy of antibody–drug conjugates (ADC) in vivo. Prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae53b5462b16aa655b56276e807d3732
https://pubmed.ncbi.nlm.nih.gov/26944918
https://pubmed.ncbi.nlm.nih.gov/26944918
Autor:
Kathy Delaria, Adela Hasa-Moreno, Ariel Ates Pios, Arvind Rajpal, Jaume Pons, Magdalena Dorywalska, Russell Dushin, Meritxell Galindo Casas, Janette Sutton, Thayalan Navaratnam, Santiago E. Farias, Kevin Lindquist, Pavel Strop, Dahui Zhou, Shu-Hui Liu, Davide Foletti, Thomas-Toan Tran, David L. Shelton, Kristian Todd Poulsen, Victor Lui, Bora Han, Jody Melton Witt
Publikováno v:
Nature biotechnology. 33(7)
Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9812c0738c909e9785335c9ff56855c1
https://pubmed.ncbi.nlm.nih.gov/26154005
https://pubmed.ncbi.nlm.nih.gov/26154005
Autor:
Chakrapani Subramanyam, Kelly R. Bales, Thayalan Navaratnam, Gregory W. Kauffman, Cory Michael Stiff, Patrick Robert Verhoest, Benjamin Adam Fish, Beth C. Vetelino, Michael Eric Green, Tuan P. Tran, Longfei Xie, Douglas S. Johnson, Leslie R. Pustilnik, Nikolay Pozdnyakov, Christopher W. am Ende, Kathleen M. Wood, Martin Pettersson, Patrick B. Mullins, Christopher J. O’Donnell, Liming Zhang, Subas M. Sakya
Publikováno v:
Journal of medicinal chemistry. 57(3)
Herein we describe the design and synthesis of a novel series of γ-secretase modulators (GSMs) that incorporates a pyridopiperazine-1,6-dione ring system. To align improved potency with favorable ADME and in vitro safety, we applied prospective phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3cdd40c6f74cd4cce9371d25fddf55
https://pubmed.ncbi.nlm.nih.gov/24428186
https://pubmed.ncbi.nlm.nih.gov/24428186