Multi-Omics Atlas-Assisted Discovery of Transcription Factors for Selective T Cell State Programming.

Autor: Chung HK, Liu C, Jambor AN, Riesenberg BP, Sun M, Casillas E, Chick B, Wang J, Ma S, Mcdonald B, He P, Yang Q, Chen T, Varanasi SK, LaPorte M, Mann TH, Chen D, Hoffmann F, Tripple V, Ho J, Cho UH, Modliszewski J, Williams A, Liu L, Wang Y, Hargreaves DC, Thaxton JE, Kaech SM, Wang W

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 18. Date of Electronic Publication: 2024 Sep 18.

Progressively Enhancing Stemness of Adoptively Transferred T Cells with PI3Kδ Blockade Improves Metabolism and Antitumor Immunity.

Autor: Rangel Rivera GO; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia.; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina., Dwyer CJ; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina., Knochelmann HM; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia.; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina., Smith AS; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia.; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina., Aksoy BA; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina., Cole AC; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia., Wyatt MM; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia., Kumaresan S; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia., Thaxton JE; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Immunotherapy Program, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Lesinski GB; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia., Paulos CM; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Publikováno v: Cancer research [Cancer Res] 2024 Jan 02; Vol. 84 (1), pp. 69-83.

Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer.

Autor: Riesenberg BP; Immunotherapy Program, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Hunt EG; Immunotherapy Program, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Tennant MD; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina., Hurst KE; Immunotherapy Program, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Andrews AM; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Leddy LR; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Neskey DM; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Hill EG; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.; Department of Public Health Sciences, Hollings Cancer Center Biostatistics Shared Resource, Medical University of South Carolina, Charleston, South Carolina., Rivera GOR; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.; Department of Surgery and Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia., Paulos CM; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.; Department of Surgery and Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia., Gao P; Department of Medicine, Metabolomics Core Facility, Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Thaxton JE; Immunotherapy Program, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Publikováno v: Cancer research [Cancer Res] 2022 Dec 02; Vol. 82 (23), pp. 4386-4399.

B cells imprint adoptively transferred CD8 ⁺ T cells with enhanced tumor immunity.

Autor: Smith AS; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA aubrey.s.smith@emory.edu chrystal.mary.paulos@emory.edu.; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia, USA.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Knochelmann HM; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia, USA.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Wyatt MM; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia, USA.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Rangel Rivera GO; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia, USA.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Rivera-Reyes AM; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia, USA.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Dwyer CJ; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Ware MB; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia, USA.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Cole AC; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia, USA.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Neskey DM; Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.; Department of Cell and Molecular Pharmacology and Developmental Therapeutics, Medical University of South Carolina, Charleston, South Carolina, USA., Rubinstein MP; Division of Medical Oncology, The Ohio State University, Columbus, Ohio, USA., Liu B; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA., Thaxton JE; Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Immunotherapy Program, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bartee E; Department of Internal Medicine, Division of Molecular Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Paulos CM; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA aubrey.s.smith@emory.edu chrystal.mary.paulos@emory.edu.; Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia, USA.; Department of Microbiology and Immunology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2022 Jan; Vol. 10 (1).

Stress relief for cancer immunotherapy: implications for the ER stress response in tumor immunity.

Autor: Andrews AM; Department of Orthopedics and Physical Medicine, Medical University of South Carolina, 68 President Street, Charleston, SC, 29425, USA.; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 29425, USA.; Hollings Cancer Center, Charleston, SC, 29425, USA., Tennant MD; Department of Orthopedics and Physical Medicine, Medical University of South Carolina, 68 President Street, Charleston, SC, 29425, USA.; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 29425, USA., Thaxton JE; Department of Orthopedics and Physical Medicine, Medical University of South Carolina, 68 President Street, Charleston, SC, 29425, USA. thaxton@musc.edu.; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 29425, USA. thaxton@musc.edu.; Hollings Cancer Center, Charleston, SC, 29425, USA. thaxton@musc.edu.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 May; Vol. 70 (5), pp. 1165-1175. Date of Electronic Publication: 2020 Oct 26.