Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Thaworn Kowithayakorn"'
Autor:
Midori A. Arai, Ryuta Akamine, Anna Tsuchiya, Tatsuro Yoneyama, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Aberrant activation of Notch signaling contributes to the pathogenesis of several different types of cancer, and Notch pathway inhibitors may have significant therapeutic potential. Using a unique cell-based assay system, we isolated twelve
Externí odkaz:
https://doaj.org/article/b9da3072ca0548b6a685bd903eb53e39
Autor:
Masami Ishibashi, Midori A. Arai, Yoshinori Makita, Takashi Koyano, Thaworn Kowithayakorn, Anna Tsuchiya
Publikováno v:
Journal of Natural Medicines. 74:758-766
Since Notch signaling plays important roles in cell proliferation and differentiation, aberrant activation of this signaling contributes to cancer progression. In neural stem cells, Notch signaling inhibits differentiation by activating HES1 expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6af6d5bd978211e050dcb80023704bd
https://doi.org/10.1007/s11418-020-01432-7
https://doi.org/10.1007/s11418-020-01432-7
Autor:
Utpal Kumar Karmakar, Thaworn Kowithayakorn, Takashi Koyano, Masami Ishibashi, Midori A. Arai
Publikováno v:
Tetrahedron Letters. 58:3838-3841
TRAIL is a promising anticancer agent due to its unique ability to kill tumor cells selectively without harming non-malignant cells. However, some cancer cells are reported to be TRAIL - resistant. Searching potent TRAIL agonist to overcome resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6231908582ff31f7108f7629b050c164
https://doi.org/10.1016/j.tetlet.2017.08.055
https://doi.org/10.1016/j.tetlet.2017.08.055
Autor:
Masami Ishibashi, Atsushi Iwama, Takashi Koyano, Kazufumi Toume, Midori A. Arai, Naoki Ishikawa, Thaworn Kowithayakorn, Tetsuhiro Chiba, Yui Kaneta
Publikováno v:
Journal of Natural Products. 80:1853-1859
B-Cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) is a core component of the polycomb repressive complex 1 (PRC1). Abnormal expression of BMI1 is associated with a number of human malignances and cancer stem cells (CSCs), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a3855d3c405054365348705dddba8a
https://doi.org/10.1021/acs.jnatprod.7b00138
https://doi.org/10.1021/acs.jnatprod.7b00138
Autor:
Midori A. Arai, Yixizhuoma, Takashi Koyano, Tomoyuki Sato, Thaworn Kowithayakorn, Masami Ishibashi, Yasumasa Hara
Publikováno v:
Journal of natural medicines. 74(2)
Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane sesquiterpenoids, including three new compounds (1–3), were isolated from wood extracts of Santalum albu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91187e825facbce91c2f5218dac30cdc
https://pubmed.ncbi.nlm.nih.gov/31863259
https://pubmed.ncbi.nlm.nih.gov/31863259
Autor:
Masami Ishibashi, Midori A. Arai, Naoki Ishikawa, Akiko Suganami, Kenji Uemura, Mitsuha Tanaka, Thaworn Kowithayakorn, Noriko Sugimitsu, Takashi Koyano, Yutaka Tamura
Publikováno v:
Chemical Science. 7:1514-1520
The Hes1 dimer inhibitor, agalloside (2), which can accelerate the differentiation of neural stem cells is described. Six natural products, including one new natural product, which bind to Hes1 were rapidly isolated by a developed "target protein ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dc2757ab1bd3e0e4c4ba51cb043f103
https://doi.org/10.1039/c5sc03540f
https://doi.org/10.1039/c5sc03540f
Autor:
Ryuta Akamine, Masami Ishibashi, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Narumi Hayashi
Publikováno v:
Journal of natural products. 81(5)
Notch signaling plays a crucial role in differentiation and cell maintenance, but once aberrantly activated, it contributes to cancer progression. Notch inhibitors were isolated from plant extracts and tested using an originally constructed cell-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38de02d8137dfa4989d7a5ecdb11de32
https://pubmed.ncbi.nlm.nih.gov/29693393
https://pubmed.ncbi.nlm.nih.gov/29693393
Autor:
Kensuke Ohishi, Kazufumi Toume, Midori A. Arai, Masami Ishibashi, Takamasa Mizoguchi, Thaworn Kowithayakorn, Takashi Koyano, Motoyuki Itoh
Publikováno v:
Journal of Natural Products. 78:1139-1146
Wnt signaling regulates various processes such as cell proliferation, differentiation, and embryo development. However, numerous diseases have been attributed to the aberrant transduction of Wnt signaling. We screened a plant extract library targetin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4638e0c3bf8274d3121694fd1c5a15a
https://doi.org/10.1021/acs.jnatprod.5b00153
https://doi.org/10.1021/acs.jnatprod.5b00153
Autor:
Nozomi Hamahiga, Tagrid Kaddar, Takashi Koyano, Midori A. Arai, Kenji Uemura, Thaworn Kowithayakorn, Madeleine Carreau, Masami Ishibashi, Naoki Ishikawa
Publikováno v:
MedChemComm. 6:455-460
The isolation and evaluation of inhibitors of Fanconi F protein (FANCF) – hairy and enhancer of split 1 (Hes1) complex are described. A high-throughput screening assay for small-molecule inhibitors of the FANCF–Hes1 complex was realized. Successf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b6febe4618f8e65491bbfa3fd021b46
https://doi.org/10.1039/c4md00495g
https://doi.org/10.1039/c4md00495g
Autor:
Tatsuro Yoneyama, Takashi Koyano, Ryuta Akamine, Thaworn Kowithayakorn, Anna Tsuchiya, Midori A. Arai, Masami Ishibashi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Aberrant activation of Notch signaling contributes to the pathogenesis of several different types of cancer, and Notch pathway inhibitors may have significant therapeutic potential. Using a unique cell-based assay system, we isolated twelve compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c92d1b55417e8e2163c77dd4d5be65c
https://pubmed.ncbi.nlm.nih.gov/29599482
https://pubmed.ncbi.nlm.nih.gov/29599482