Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.

Autor: Walter JD; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Scherer M; Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Hutter CAJ; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Garaeva AA; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.; Department of Membrane Enzymology at the Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands., Zimmermann I; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.; Linkster Therapeutics AG, Zurich, Switzerland., Wyss M; Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Rheinberger J; Department of Structural Biology at the Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands., Ruedin Y; Institute of Virology and Immunology, Bern & Mittelhäusern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Earp JC; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Egloff P; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.; Linkster Therapeutics AG, Zurich, Switzerland., Sorgenfrei M; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Hürlimann LM; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Gonda I; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Meier G; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Remm S; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Thavarasah S; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., van Geest G; Interfaculty Bioinformatics Unit and Swiss, Institute of Bioinformatics, University of Bern, Bern, Switzerland., Bruggmann R; Interfaculty Bioinformatics Unit and Swiss, Institute of Bioinformatics, University of Bern, Bern, Switzerland., Zimmer G; Institute of Virology and Immunology, Bern & Mittelhäusern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Slotboom DJ; Department of Membrane Enzymology at the Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands., Paulino C; Department of Membrane Enzymology at the Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.; Department of Structural Biology at the Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands., Plattet P; Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Seeger MA; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.

Publikováno v: EMBO reports [EMBO Rep] 2022 Apr 05; Vol. 23 (4), pp. e54199. Date of Electronic Publication: 2022 Mar 07.

Mapping temperature‐sensitive mutations at a genome scale to engineer growth switches in Escherichia coli.

Autor: Schramm, Thorben^1,2 (AUTHOR), Lubrano, Paul^1,2 (AUTHOR), Pahl, Vanessa^1,2 (AUTHOR), Stadelmann, Amelie^1,2 (AUTHOR), Verhülsdonk, Andreas^1,2 (AUTHOR), Link, Hannes^1,2 (AUTHOR) hannes.link@uni-tuebingen.de

Publikováno v: Molecular Systems Biology. 10/12/2023, Vol. 19 Issue 10, p1-19. 19p.

Fitness landscape of substrate-adaptive mutations in evolved amino acidpolyamine-organocation transporters.

Autor: Karapanagioti, Foteini, Atlason, Úlfur Águst, Slotboom, Dirk J., Poolman, Bert, Obermaier, Sebastian

Publikováno v: eLife; 6/25/2024, p1-24, 24p