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of 3
pro vyhledávání: '"Thatcher B. Ference"'
Autor:
Stephen Kaptoge, Ulrich Laufs, Arjen J. Cupido, Christian T. Ruff, Thatcher B. Ference, George Davey Smith, Alberico L. Catapano, Ian D. Graham, Marc S. Sabatine, Chris J. Packard, Michael V. Holmes, Stephen J. Nicholls, Brian A. Ference, Kausik K. Ray, Qi Guo, G. Kees Hovingh, Deepak L. Bhatt, John Danesh
Publikováno v:
Ference, B, Bhatt, D, Catapano, A L, Packard, C J, Graham, I, Kaptoge, S, Ference, T B, Guo, Q, Laufs, U, Ruff, C T, Capuido, A, Kees Hovingh, G, Danesh, J, Holmes, M V, Davey Smith, G, Ray, K K, Nicholls, S J & Sabatine, M S 2019, ' Associations of Genetic Variants Related to Combined Exposure to both Lower Low-Density Lipoproteins and Lower Systolic Blood Pressure with Lifetime Risk of Cardiovascular Disease ', JAMA Network Open, vol. 322, no. 14, pp. 1381-1391 . https://doi.org/10.1001/jama.2019.14120
JAMA, 322(14), 1381-1391. American Medical Association
JAMA, 322(14), 1381-1391. American Medical Association
IMPORTANCE: The relationship between exposure to lower low-density lipoprotein cholesterol (LDL-C) and lower systolic blood pressure (SBP) with the risk of cardiovascular disease has not been reliably quantified. OBJECTIVE: To assess the association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dab7da739f316fbe2256b972f72f61f
http://hdl.handle.net/10044/1/73588
http://hdl.handle.net/10044/1/73588
Autor:
David R. Neff, Thatcher B. Ference, John J.P. Kastelein, Brian A. Ference, Adam S. Butterworth, Clare Oliver-Williams, Stephen Burgess, Emanuele Di Angelantonio, Alberico L. Catapano, Angela M. Wood, John Danesh, Stephen J. Nicholls, Kausik K. Ray
Publikováno v:
N Engl J Med
New England journal of medicine, 380(11), 1033-1042. Massachussetts Medical Society
New England journal of medicine, 380(11), 1033-1042. Massachussetts Medical Society
BACKGROUND: ATP citrate lyase is an enzyme in the cholesterol–biosynthesis pathway upstream of 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR), the target of statins. Whether the genetic inhibition of ATP citrate lyase is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357a5c0922cd54fa05e62528a110ec76
https://europepmc.org/articles/PMC7612927/
https://europepmc.org/articles/PMC7612927/
Autor:
Thatcher B. Ference, Brian A. Ference
Publikováno v:
Journal of the American College of Cardiology. 71:A1855
Cardiovascular Clinical Guidelines recommend making treatment decisions based on a person's estimated risk of cardiovascular events (ASCVD). However, the precision of these risk estimates is unknown. We developed an algorithm to estimate the confiden