Have plastic culture models prevented the discovery of effective cancer therapeutics?

Autor: Tharp KM; Cancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Nov 03. Date of Electronic Publication: 2024 Nov 03.

Growth on stiffer substrates impacts animal health and longevity in C. elegans.

Autor: Oorloff M; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Hruby A; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Averbukh M; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Alcala A; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Dutta N; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Minor C; Cancer Metabolism and Microenvironment Program, Sanford Burnham Prebys, La Jolla, CA, United States of America., Castro Torres T; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Moaddeli D; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Vega M; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Kim J; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Bong A; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Coakley AJ; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Hicks D; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Wang J; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Wang T; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Hoang S; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Tharp KM; Cancer Metabolism and Microenvironment Program, Sanford Burnham Prebys, La Jolla, CA, United States of America., Garcia G; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America., Higuchi-Sanabria R; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States of America.

Publikováno v: PloS one [PLoS One] 2024 Sep 12; Vol. 19 (9), pp. e0302673. Date of Electronic Publication: 2024 Sep 12 (Print Publication: 2024).

Tumor-associated macrophages restrict CD8 ⁺ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.

Autor: Tharp KM; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Kersten K; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA., Maller O; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Timblin GA; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Stashko C; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Canale FP; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Menjivar RE; Department of Surgery, University of Michigan, Ann Arbor, MI, USA., Hayward MK; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Berestjuk I; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Ten Hoeve J; UCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA., Samad B; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA., Ironside AJ; Department of Pathology, Western General Hospital, NHS Lothian, Edinburgh, UK., di Magliano MP; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, Cancer Biology Program, University of Michigan, Ann Arbor, MI, USA., Muir A; Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA., Geiger R; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Combes AJ; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Weaver VM; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA. valerie.weaver@ucsf.edu.; Department of Bioengineering and Therapeutic Sciences and Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and The Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. valerie.weaver@ucsf.edu.

Publikováno v: Nature cancer [Nat Cancer] 2024 Jul; Vol. 5 (7), pp. 1045-1062. Date of Electronic Publication: 2024 Jun 03.

The microenvironment dictates glycocalyx construction and immune surveillance.

Autor: Tharp KM; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA., Park S; Field of Biophysics, Cornell University, Ithaca, NY 14850, USA., Timblin GA; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA., Richards AL; Quantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Berg JA; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Twells NM; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada., Riley NM; Department of Chemistry, Sarafan ChEM-H, Stanford University, Stanford, CA, USA., Peltan EL; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford CA USA 94305.; Sarafan ChEM-H, Stanford University, Stanford, CA USA 94305., Shon DJ; Department of Chemistry, Sarafan ChEM-H, Stanford University, Stanford, CA, USA., Stevenson E; Quantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Tsui K; Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94597, USA., Palomba F; Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, California, CA 92697, USA., Lefebvre AEYT; Calico Life Sciences, South San Francisco, CA, USA., Soens RW; Morgridge Institute for Research, Madison, WI 53715, USA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA., Ayad NME; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA., Hoeve-Scott JT; UCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA., Healy K; Department of Chemical and Systems Biology, Sarafan ChEM-H and Howard Hughes Medical Institute, Stanford University, Stanford, CA USA 94305., Digman M; Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, California, CA 92697, USA., Dillin A; Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94597, USA., Bertozzi CR; Department of Chemical and Systems Biology, Sarafan ChEM-H and Howard Hughes Medical Institute, Stanford University, Stanford, CA USA 94305., Swaney DL; Quantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Mahal LK; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada., Cantor JR; Morgridge Institute for Research, Madison, WI 53715, USA; Department of Biochemistry and Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA., Paszek MJ; Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA., Weaver VM; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.; Department of Bioengineering and Therapeutic Sciences, Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, CA 94143, USA.

Publikováno v: Research square [Res Sq] 2023 Aug 16. Date of Electronic Publication: 2023 Aug 16.

Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.

Autor: Ferguson ID; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA., Lin YT; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA., Lam C; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA., Shao H; Institute for Neurodegenerative Disease, University of California, San Francisco, San Francisco, CA 94158, USA., Tharp KM; Department of Surgery, University of California, San Francisco, San Francisco CA 94143, USA., Hale M; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA., Kasap C; Department of Medicine, Division of Hematology or Oncology, University of California, San Francisco, San Francisco, CA 94143, USA., Mariano MC; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA., Kishishita A; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA; Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, San Francisco, CA 94158, USA., Patiño Escobar B; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA., Mandal K; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA., Steri V; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Wang D; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Phojanakong P; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Tuomivaara ST; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA., Hann B; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Driessen C; Department of Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland., Van Ness B; Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA., Gestwicki JE; Institute for Neurodegenerative Disease, University of California, San Francisco, San Francisco, CA 94158, USA., Wiita AP; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA. Electronic address: arun.wiita@ucsf.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2022 Aug 18; Vol. 29 (8), pp. 1288-1302.e7. Date of Electronic Publication: 2022 Jul 18.