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Distinct SIV-specific CD8 ⁺ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence.

Autor: Strongin Z; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Raymond Marchand L; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Deleage C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA., Pampena MB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for AIDS Research and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cardenas MA; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Beusch CM; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Hoang TN; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Urban EA; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA., Gourves M; Institut Pasteur, Université Paris Cité, Viral Reservoirs and Immune Control Unit, Paris, France.; Institut Pasteur, Université Paris Cité, HIV Inflammation and Persistence Unit, Paris, France., Nguyen K; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Tharp GK; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Lapp S; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Rahmberg AR; Barrier Immunity Section, Laboratory of Viral Diseases, NIAIDNIH, Bethesda, MD, USA., Harper J; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Del Rio Estrada PM; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Gonzalez-Navarro M; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Torres-Ruiz F; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Luna-Villalobos YA; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Avila-Rios S; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Reyes-Teran G; Comision Coordinadora de los Institutos Nacionales de Salud y Hospitales de Alta Especialidad, Mexico City, Mexico., Sekaly R; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Silvestri G; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA., Kulpa DA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Saez-Cirion A; Institut Pasteur, Université Paris Cité, Viral Reservoirs and Immune Control Unit, Paris, France.; Institut Pasteur, Université Paris Cité, HIV Inflammation and Persistence Unit, Paris, France., Brenchley JM; Barrier Immunity Section, Laboratory of Viral Diseases, NIAIDNIH, Bethesda, MD, USA., Bosinger SE; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA., Gordon DE; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for AIDS Research and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kissick HT; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Paiardini M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA. mirko.paiardini@emory.edu.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA. mirko.paiardini@emory.edu.; Emory Vaccine Center, Emory University, Atlanta, GA, USA. mirko.paiardini@emory.edu.

Publikováno v: Nature immunology [Nat Immunol] 2024 Jul; Vol. 25 (7), pp. 1245-1256. Date of Electronic Publication: 2024 Jun 17.

The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression.

Autor: Wang Q; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Clark KM; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Tiwari R; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Raju N; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Tharp GK; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Rogers J; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Harris RA; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Raveendran M; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Bosinger SE; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Burdo TH; Department of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Silvestri G; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Shan L; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address: liang.shan@wustl.edu.

Publikováno v: Cell [Cell] 2024 Feb 29; Vol. 187 (5), pp. 1223-1237.e16.

Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD.

Autor: Gupta PM; Emory National Primate Research Center (ENPRC) Genomics Core Laboratory, Division of Microbiology & Immunology, Emory University, Atlanta, GA, USA., Balle C; Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa., Tharp GK; Emory National Primate Research Center (ENPRC) Genomics Core Laboratory, Division of Microbiology & Immunology, Emory University, Atlanta, GA, USA., Nelson SA; Emory National Primate Research Center (ENPRC) Genomics Core Laboratory, Division of Microbiology & Immunology, Emory University, Atlanta, GA, USA., Gasper MA; Seattle Children's Research Institute, Seattle, WA, USA., Brown B; Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA., Alisoltani A; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Onono M; Kenya Medical Research Institute, Kisumu, Kenya., Palanee-Phillips T; Wits RHI, University of the Witwatersrand, Faculty of Health Sciences, School of Public Health, Johannesburg, South Africa; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Nair G; Desmond Tutu HIV Centre, Cape Town, South Africa., Ayele H; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Noel-Romas L; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Passmore JS; Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; National Health Laboratory Service, Cape Town, South Africa; CAPRISA DSI-NRF Centre of Excellence in HIV Prevention, University of Cape Town, South Africa., Burgener AD; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Heffron R; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA., Jaspan HB; Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA., Bosinger SE; Emory University School of Medicine, Department of Pathology & Laboratory Medicine, GA, USA; Emory Vaccine Center, Emory University, GA, USA. Electronic address: steven.bosinger@emory.edu.

Publikováno v: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2023 Oct; Vol. 255, pp. 109750. Date of Electronic Publication: 2023 Sep 03.

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.

Autor: Viox EG; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Hoang TN; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Upadhyay AA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Nchioua R; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Hirschenberger M; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Strongin Z; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Tharp GK; Emory NPRC Genomics Core Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Pino M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Nguyen K; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Harper JL; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Gagne M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Marciano S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel., Boddapati AK; Emory NPRC Genomics Core Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Pellegrini KL; Emory NPRC Genomics Core Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Pradhan A; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Tisoncik-Go J; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA., Whitmore LS; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA., Karunakaran KA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Roy M; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Kirejczyk S; StageBio, 5930 Main St., Mount Jackson, VA 22842, USA., Curran EH; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Wallace C; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Wood JS; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Connor-Stroud F; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Voigt EA; RNA Vaccines Group, Access to Advanced Health Institute, Seattle, WA 98102, USA., Monaco CM; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA., Gordon DE; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA., Kasturi SP; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA., Levit RD; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA., Gale M Jr; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA., Vanderford TH; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Silvestri G; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA., Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA., Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.; Department of Clinical Medicine, Aarhus University, Aarhus 8000, Denmark.; School of Health and Biomedical Sciences, College of Science, Engineering and Health, RMIT University, Melbourne, VIC 3000, Australia., Vaccari M; Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane School of Medicine, New Orleans, LA 70112, USA., Douek DC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Johnson RP; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Infectious Disease Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Schreiber G; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel., Bosinger SE; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Emory NPRC Genomics Core Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA., Paiardini M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.

Publikováno v: Science immunology [Sci Immunol] 2023 Jul 28; Vol. 8 (85), pp. eadg0033. Date of Electronic Publication: 2023 Jul 28.