Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tharindumala Abeywardana"'
Publikováno v:
Biomolecules, Vol 5, Iss 3, Pp 1210-1227 (2015)
α-Synuclein is the aggregation-prone protein associated with Parkinson’s disease (PD) and related neurodegenerative diseases. Complicating both its biological functions and toxic aggregation are a variety of posttranslational modifications. These
Externí odkaz:
https://doaj.org/article/31959b78c6de42eb9d845db3f687c2b6
Autor:
Guan Wang, Lei Jiang, Yanzhong Yang, Wenting Dai, Jason Chwa, Myung Eun Oh, Tharindumala Abeywardana, Qiong A. Wang
Publikováno v:
British Journal of Cancer
Background Previous studies suggested that mdivi-1 (mitochondrial division inhibitor), a putative inhibitor of dynamin-related protein (DRP1), decreased cancer cell proliferation through inducing mitochondrial fusion and altering oxygen consumption.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81c0c6f353b6d3a465ba65e63bce935
http://europepmc.org/articles/PMC7188673
http://europepmc.org/articles/PMC7188673
Autor:
Samir Adhikari, Zhihao Wang, Bryan T. Harada, Zhicheng Pan, Chuan He, Tharindumala Abeywardana, Wei Yuan, Jeremy M. Stark, Qais Al-Hadid, Yanzhong Yang, Lei Shen, Lan Lin
Publikováno v:
EMBO J
The N6‐methyladenosine (m(6)A) RNA modification serves crucial functions in RNA metabolism; however, the molecular mechanisms underlying the regulation of m(6)A are not well understood. Here, we establish arginine methylation of METTL14, a componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b598599690141c6a8c08968e182e7617
https://europepmc.org/articles/PMC7917551/
https://europepmc.org/articles/PMC7917551/
Publikováno v:
ACS Chemical Biology. 11:931-942
The reversible modification of protein by the small protein ubiquitin and other ubiquitin-like modifiers plays important roles in virtually every key biological process in eukaryotic cells. The establishment of a range of chemical methods for the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23eec64bcd7d1385665d05e0e8bebeb9
https://doi.org/10.1021/acschembio.5b01042
https://doi.org/10.1021/acschembio.5b01042
Autor:
Jikui Song, Myungeun Oh, Mei Kong, Tharindumala Abeywardana, Ying Yang, Lei Jiang, Yanzhong Yang
Publikováno v:
The Journal of biological chemistry, vol 293, iss 39
Glucose is a critical nutrient for cell proliferation. However, the molecular pathways that regulate glucose metabolism are still elusive. We discovered that co-activator-associated arginine methyltransferase 1 (CARM1) suppresses glucose metabolism t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa8a6131a6b3ff9215abe6186e29c17
https://europepmc.org/articles/PMC6166735/
https://europepmc.org/articles/PMC6166735/
Publikováno v:
Chemistry & Biology. 20(10):1207-1213
Summary The formation of toxic aggregates composed largely of the protein α-synuclein are a hallmark of Parkinson's disease. Evidence from both early-onset forms of the disease in humans and animal models has shown that the progression of the diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b23a31f50efd4924e618a68df83b18f
Publikováno v:
Biochemistry. 54(4)
α-Synuclein, the major aggregating protein in Parkinson’s disease, can be modified by the small protein SUMO, indicating a potential role in disease. However, the effects of SUMOylation on α-synuclein aggregation remain controversial due to heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda39eb0682a3615ede0d3c0f3bd077e
https://pubmed.ncbi.nlm.nih.gov/25607946
https://pubmed.ncbi.nlm.nih.gov/25607946
Publikováno v:
Chembiochem : a European journal of chemical biology. 15(11)
Chemistry has long played an indispensable role in biological discovery through the synthesis of homogeneous, structurally defined material. With continuing advances in the area of synthetic protein chemistry, chemists are able to prepare increasingl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3b0d77fde302a8819bd41dd764c96b
https://pubmed.ncbi.nlm.nih.gov/24976261
https://pubmed.ncbi.nlm.nih.gov/24976261
Publikováno v:
Chembiochem : a European journal of chemical biology. 13(18)
Aberrant protein folding and aggregation are implicated in numerous diseases and represent a key challenge to biological and chemical investigations aimed at eventual therapies. One class is neurodegenerative diseases associated with the aggregation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e565f9fdc056181b459da51957ba61c
https://pubmed.ncbi.nlm.nih.gov/23143740
https://pubmed.ncbi.nlm.nih.gov/23143740
Autor:
Abhinav Dhall, Nicholas P. Marotta, Franziska Meier, Matthew R. Pratt, Champak Chatterjee, Ralf Langen, Jobin Varkey, Tharindumala Abeywardana
Publikováno v:
Journal of the American Chemical Society. 134(12)
The process of neurodegeneration in Parkinson’s Disease is intimately associated with the aggregation of the protein α-synuclein into toxic oligomers and fibrils. Interestingly, many of these protein aggregates are found to be post-translationally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0dac118ea4ecb21975ebde0c34763ad
https://pubmed.ncbi.nlm.nih.gov/22404520
https://pubmed.ncbi.nlm.nih.gov/22404520