Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thapsia (plant)"'
Autor:
Federico Cozzi, T. Bundgaard Andersen, K Martinez, Christopher Barnes, Henrik Toft Simonsen, Berin A. Boughton, Nina Rønsted
Publikováno v:
Planta Medica. 81:S1-S381
Thapsigargin, a guaianolide sesquiterpene lactone, is the active component of a pro-drug currently in phase 2 of clinical trials for the treatment of solid tumours. Thapsigargin is currently only being isolated from Thapsia garganica L. (Apiaceae); a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00f9d9c56005a57df329ff8c77998d5c
https://doi.org/10.1055/s-0036-1596793
https://doi.org/10.1055/s-0036-1596793
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 4, p 4 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 4, p 4 (2021)
A sesquiterpene lactone, thapsigargin, is a phytochemical found in the roots and fruits of Mediterranean plants from Thapsia L. species that have been used for centuries in folk medicine to treat rheumatic pain, lung diseases, and female infertility.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ef21a24b971417442e3d4109be8629
https://doi.org/10.3390/ijms22010004
https://doi.org/10.3390/ijms22010004
Autor:
Silas Anselm Rasmussen, Henrik Toft Simonsen, Trine Bundgaard Andersen, Søren Brøgger Christensen
Publikováno v:
Andersen, T B, Rasmussen, S A, Christensen, S B & Simonsen, H T 2019, ' Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy ', Phytochemistry, vol. 157, pp. 168-174 . https://doi.org/10.1016/j.phytochem.2018.10.027
Andersen, T B, Rasmussen, S A, Christensen, S B & Simonsen, H T 2019, ' Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy ', Phytochemistry, vol. 157, no. https://doi.org/10.1016/j.phytochem.2018.10.027, pp. 168-174 . https://doi.org/10.1016/j.phytochem.2018.10.027
Andersen, T B, Rasmussen, S A, Christensen, S B & Simonsen, H T 2019, ' Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy ', Phytochemistry, vol. 157, no. https://doi.org/10.1016/j.phytochem.2018.10.027, pp. 168-174 . https://doi.org/10.1016/j.phytochem.2018.10.027
The genus Thapsia produces a wide variety of sesquiterpenoids. The Mediterranean plant Thapsia laciniata Rouy is known to have a product profile that differs from several other species in the genus. Thus, the biosynthesis of sesquiterpenoids in Thaps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d8da476301c7340f3f5b1376e9ed79
https://pubmed.ncbi.nlm.nih.gov/30412824
https://pubmed.ncbi.nlm.nih.gov/30412824
Autor:
Tom Manczak, Trine Bundgaard Andersen, Carmen Quinonero Lopez, Karen Agatha Martinez, Henrik Toft Simonsen
Publikováno v:
Molecules
Andersen, T B, Quinonero Lopez, C, Manczak, T, Martinez, K A & Simonsen, H T 2015, ' Thapsigargin-from Thapsia L. to Mipsagargin ', Molecules, vol. 20, no. 4, pp. 6113-6127 . https://doi.org/10.3390/molecules20046113
Molecules, Vol 20, Iss 4, Pp 6113-6127 (2015)
Andersen, T B, Quinonero Lopez, C, Manczak, T, Martinez, K A & Simonsen, H T 2015, ' Thapsigargin-from Thapsia L. to Mipsagargin ', Molecules, vol. 20, no. 4, pp. 6113-6127 . https://doi.org/10.3390/molecules20046113
Molecules, Vol 20, Iss 4, Pp 6113-6127 (2015)
The sesquiterpene lactone thapsigargin is found in the plant Thapsia garganica L., and is one of the major constituents of the roots and fruits of this Mediterranean species. In 1978, the first pharmacological effects of thapsigargin were established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5941d8a515767e28709e65175bd0df4c
https://doi.org/10.3390/molecules20046113
https://doi.org/10.3390/molecules20046113
Publikováno v:
Botanical Journal of the Linnean Society. 174:620-636
Thapsia is a small genus of herbaceous perennials in Apiaceae. Thapsia occurs around the Mediterranean, extending from the Atlantic coasts of Portugal and Morocco to Crete and other Greek Islands. Thapsia is commonly known as deadly carrot because of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cce655a7b8f9ca5b3d53538ea39b3fe
https://doi.org/10.1111/boj.12144
https://doi.org/10.1111/boj.12144
Autor:
Damian P. Drew, Ye Zhang, Corinna Weitzel, Christoph Wilhelm Sensen, Henrik Toft Simonsen, Bjørn Dueholm
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 14; Issue 5; Pages: 9080-9098
International Journal of Molecular Sciences, Vol 14, Iss 5, Pp 9080-9098 (2013)
International Journal of Molecular Sciences; Volume 14; Issue 5; Pages: 9080-9098
International Journal of Molecular Sciences, Vol 14, Iss 5, Pp 9080-9098 (2013)
Thapsia laciniata Rouy (Apiaceae) produces irregular and regular sesquiterpenoids with thapsane and guaiene carbon skeletons, as found in other Apiaceae species. A transcriptomic analysis utilizing Illumina next-generation sequencing enabled the iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a719dcf8495ef9a58dfa374ecb0711e1
http://europepmc.org/articles/PMC3676774
http://europepmc.org/articles/PMC3676774
Autor:
Lígia Salgueiro, Maria José Gonçalves, Maria do Carmo Lopes, Jorge Canhoto, Maria Teresa Cruz, Ana Cristina Tavares, Carlos Cavaleiro
Publikováno v:
Industrial Crops and Products. 35:166-171
The essential oils from aerial parts of Thapsia minor Hoffmanns. & Link (Apiaceae), obtained by hydrodistillation, were analyzed by gas-chromatography and gas-chromatography–mass spectrometry. Oxygenated monoterpenes represented the main fraction w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e87ea172210000ed50752f0f2c6c8ca4
https://doi.org/10.1016/j.indcrop.2011.06.030
https://doi.org/10.1016/j.indcrop.2011.06.030
Publikováno v:
Phytochemical Analysis. 23:44-51
Introduction – Thapsia spp. (Apiaceae) are the major natural source of polyoxygenated guaianolide sesquiterpene lactones known as thapsigargins, which induce apoptosis in mammalian cells via a high affinity inhibition of the sarco/endoplasmic retic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eac497744a3257e4c80c8605aa31e8d
https://doi.org/10.1002/pca.1323
https://doi.org/10.1002/pca.1323
Publikováno v:
Phytochemistry Reviews. 8:581-599
The guaianolide group of sesquiterpene lactones contains a large number of compounds with biological activity. One of these guaianolides, thapsigargin from the genus Thapsia (Apiaceae), has been a subject of particular interest in recent years becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e601e4ae21acf4cb5ab1879fca9d183
https://doi.org/10.1007/s11101-009-9130-z
https://doi.org/10.1007/s11101-009-9130-z
Autor:
Karla Frydenvang, F. Javier Moreno-Dorado, S. Brøgger Christensen, Ulla Wagner Smitt, Margit Eriksson, Guillermo M. Massanet, Juan J. Rubal, Zacarías D. Jorge, Helmer Søhoel, Francisco M. Guerra, Charlotte Nielsen
Publikováno v:
Journal of Natural Products. 69:1566-1571
Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also affo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59468a9982a73ed1fd11ebb67f45419
https://doi.org/10.1021/np0603065
https://doi.org/10.1021/np0603065